Robust Generation of Ready-to-Use Cryopreserved Motor Neurons from Human Pluripotent Stem Cells for Disease Modeling

Human pluripotent stem cell (hPSC)-derived motor neurons (MNs) act as models for motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS) or spinal muscular atrophy. However, the MN differentiation efficiency and viability following cryopreservation require further development for a...

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Veröffentlicht in:	International journal of molecular sciences 2022-11, Vol.23 (21), p.13462
Hauptverfasser:	Ting, Hsiao-Chien, Su, Hong-Lin, Chen, Mei-Fang, Harn, Horng-Jyh, Lin, Shinn-Zong, Chiou, Tzyy-Wen, Chang, Chia-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - metabolism Atrophy Cryopreservation Disease Drug screening Efficiency Humans Induced Pluripotent Stem Cells Maturation Morphology Motor neuron diseases Motor Neurons - metabolism Musculoskeletal system Neural stem cells Neuromuscular diseases Neuromuscular junctions Neurons Pluripotency Pluripotent Stem Cells - metabolism Progenitor cells Protein interaction Proteins Spinal cord Spinal muscular atrophy Stem cells Superoxide dismutase Superoxide Dismutase-1 - metabolism Thawing
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