Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats
Akebia quinata, commonly called chocolate vine, has various bioactivities, including antioxidant and anti-obesity properties. However, the anti-obesity effects of bioconverted extracts of A. quinate have not been examined. In this study, A. quinata fruit extracts was bioconverted using the enzyme is...
Gespeichert in:
| Veröffentlicht in: | Nutrients 2022-11, Vol.14 (21), p.4683 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 21 |
| container_start_page | 4683 |
| container_title | Nutrients |
| container_volume | 14 |
| creator | Lee, Seul Gi Lee, Eunbi Chae, Jongbeom Kim, Jin Soo Lee, Han-Saem Lim, Yu-Mi So, Jai-Hyun Hahn, Dongyup Nam, Ju-Ock |
| description | Akebia quinata, commonly called chocolate vine, has various bioactivities, including antioxidant and anti-obesity properties. However, the anti-obesity effects of bioconverted extracts of A. quinate have not been examined. In this study, A. quinata fruit extracts was bioconverted using the enzyme isolated from the soybean paste fungi Aspergillus kawachii. To determine whether the bioconversion process could influence the anti-obesity effects of A. quinata fruit extracts, we employed 3T3-L1 adipocytes and HFD-induced obese rats. We observed that the bioconverted fruit extract of A. quinata (BFE) afforded anti-obesity effects, which were stronger than that for the non-bioconverted fruit extract (FE) of A. quinata. In 3T3-L1 adipocytes, treatment with BFE at concentrations of 20 and 40 μg reduced intracellular lipids by 74.8 (p < 0.05) and 54.9% (p < 0.01), respectively, without inducing cytotoxicity in preadipocytes. Moreover, the oral administration of BFE at the concentration of 300 mg/kg/day significantly reduced body and adipose tissue weights (p < 0.01) in HFD-induced obese rats. Plasma cholesterol values were reduced, whereas HDL was increased in BFE receiving rats. Although FE could exert anti-obesity effects, BFE supplementation induced more robust effects than FE. These results could be attributed to the bioconversion-induced alteration of bioactive compound content within the extract. |
| doi_str_mv | 10.3390/nu14214683 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9656223</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A746325135</galeid><sourcerecordid>A746325135</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-a987fcaae62e92a584716cef73ed2849a3d5ee799193b94b973e2f3031cea1f13</originalsourceid><addsrcrecordid>eNptkt9rFDEQxxdRbKl98Q-QgC8ibN1kssnmRbjWO1soFEWfQzY7uUu9S-omW-x_b5bWsxWThwwzn_mS-VFVr2lzAqCaD2GinFEuOnhWHbJGsloIDs8f2QfVcUrXzXxkIwW8rA5AgOCKt4dVOPXRxnCLY8aBrMbJZ7L8lUdjM4mOLH5g7w35MvlgsimRje99TmQRsq-vekw-35Glc2iL0wdy7tebemUy-eQx1xdhmGyRnUEkX01Or6oXzmwTHj-8R9X31fLb2Xl9efX54mxxWVsuIddGddJZY1AwVMy0HZdUWHQScGAdVwaGFlEqRRX0iveqBJiDBqhFQx2Fo-rjve7N1O9wsBhKSVt9M_qdGe90NF4_jQS_0et4q5VoBWNQBN49CIzx54Qp651PFrdbEzBOSTMJbSc58K6gb_9Br-M0hlLeTJXJdKL8b0-tzRa1Dy7OTZ5F9UJyAayl0Bbq5D9UuQPufJkTOl_8TxLe3yfYMaY0otvXSBs9L4j-uyAFfvO4K3v0zzrAb0LBtE4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2734688697</pqid></control><display><type>article</type><title>Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Lee, Seul Gi ; Lee, Eunbi ; Chae, Jongbeom ; Kim, Jin Soo ; Lee, Han-Saem ; Lim, Yu-Mi ; So, Jai-Hyun ; Hahn, Dongyup ; Nam, Ju-Ock</creator><creatorcontrib>Lee, Seul Gi ; Lee, Eunbi ; Chae, Jongbeom ; Kim, Jin Soo ; Lee, Han-Saem ; Lim, Yu-Mi ; So, Jai-Hyun ; Hahn, Dongyup ; Nam, Ju-Ock</creatorcontrib><description>Akebia quinata, commonly called chocolate vine, has various bioactivities, including antioxidant and anti-obesity properties. However, the anti-obesity effects of bioconverted extracts of A. quinate have not been examined. In this study, A. quinata fruit extracts was bioconverted using the enzyme isolated from the soybean paste fungi Aspergillus kawachii. To determine whether the bioconversion process could influence the anti-obesity effects of A. quinata fruit extracts, we employed 3T3-L1 adipocytes and HFD-induced obese rats. We observed that the bioconverted fruit extract of A. quinata (BFE) afforded anti-obesity effects, which were stronger than that for the non-bioconverted fruit extract (FE) of A. quinata. In 3T3-L1 adipocytes, treatment with BFE at concentrations of 20 and 40 μg reduced intracellular lipids by 74.8 (p < 0.05) and 54.9% (p < 0.01), respectively, without inducing cytotoxicity in preadipocytes. Moreover, the oral administration of BFE at the concentration of 300 mg/kg/day significantly reduced body and adipose tissue weights (p < 0.01) in HFD-induced obese rats. Plasma cholesterol values were reduced, whereas HDL was increased in BFE receiving rats. Although FE could exert anti-obesity effects, BFE supplementation induced more robust effects than FE. These results could be attributed to the bioconversion-induced alteration of bioactive compound content within the extract.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu14214683</identifier><identifier>PMID: 36364945</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>3T3-L1 Cells ; Adipocytes ; Adipogenesis ; Adipose tissue ; Akebia quinata ; Animals ; Anti-Obesity Agents - pharmacology ; Bioactive compounds ; Biocompatibility ; Bioconversion ; Biological activity ; Biotransformation ; Body fat ; Care and treatment ; Chemical properties ; Chemical research ; Cholesterol ; Cytotoxicity ; Diet ; Diet, High-Fat - adverse effects ; Enzymes ; Fruit ; Fruits ; Health aspects ; High density lipoprotein ; High fat diet ; Insulin ; Lipids ; Mice ; Mice, Inbred C57BL ; Obesity ; Obesity - drug therapy ; Obesity - etiology ; Oral administration ; Plant Extracts - pharmacology ; Preadipocytes ; Proteins ; Ranunculaceae ; Rats ; Soybeans</subject><ispartof>Nutrients, 2022-11, Vol.14 (21), p.4683</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-a987fcaae62e92a584716cef73ed2849a3d5ee799193b94b973e2f3031cea1f13</citedby><cites>FETCH-LOGICAL-c473t-a987fcaae62e92a584716cef73ed2849a3d5ee799193b94b973e2f3031cea1f13</cites><orcidid>0000-0001-8186-0886 ; 0000-0002-1300-0101</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656223/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656223/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36364945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Seul Gi</creatorcontrib><creatorcontrib>Lee, Eunbi</creatorcontrib><creatorcontrib>Chae, Jongbeom</creatorcontrib><creatorcontrib>Kim, Jin Soo</creatorcontrib><creatorcontrib>Lee, Han-Saem</creatorcontrib><creatorcontrib>Lim, Yu-Mi</creatorcontrib><creatorcontrib>So, Jai-Hyun</creatorcontrib><creatorcontrib>Hahn, Dongyup</creatorcontrib><creatorcontrib>Nam, Ju-Ock</creatorcontrib><title>Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Akebia quinata, commonly called chocolate vine, has various bioactivities, including antioxidant and anti-obesity properties. However, the anti-obesity effects of bioconverted extracts of A. quinate have not been examined. In this study, A. quinata fruit extracts was bioconverted using the enzyme isolated from the soybean paste fungi Aspergillus kawachii. To determine whether the bioconversion process could influence the anti-obesity effects of A. quinata fruit extracts, we employed 3T3-L1 adipocytes and HFD-induced obese rats. We observed that the bioconverted fruit extract of A. quinata (BFE) afforded anti-obesity effects, which were stronger than that for the non-bioconverted fruit extract (FE) of A. quinata. In 3T3-L1 adipocytes, treatment with BFE at concentrations of 20 and 40 μg reduced intracellular lipids by 74.8 (p < 0.05) and 54.9% (p < 0.01), respectively, without inducing cytotoxicity in preadipocytes. Moreover, the oral administration of BFE at the concentration of 300 mg/kg/day significantly reduced body and adipose tissue weights (p < 0.01) in HFD-induced obese rats. Plasma cholesterol values were reduced, whereas HDL was increased in BFE receiving rats. Although FE could exert anti-obesity effects, BFE supplementation induced more robust effects than FE. These results could be attributed to the bioconversion-induced alteration of bioactive compound content within the extract.</description><subject>3T3-L1 Cells</subject><subject>Adipocytes</subject><subject>Adipogenesis</subject><subject>Adipose tissue</subject><subject>Akebia quinata</subject><subject>Animals</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Bioactive compounds</subject><subject>Biocompatibility</subject><subject>Bioconversion</subject><subject>Biological activity</subject><subject>Biotransformation</subject><subject>Body fat</subject><subject>Care and treatment</subject><subject>Chemical properties</subject><subject>Chemical research</subject><subject>Cholesterol</subject><subject>Cytotoxicity</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Enzymes</subject><subject>Fruit</subject><subject>Fruits</subject><subject>Health aspects</subject><subject>High density lipoprotein</subject><subject>High fat diet</subject><subject>Insulin</subject><subject>Lipids</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Obesity - etiology</subject><subject>Oral administration</subject><subject>Plant Extracts - pharmacology</subject><subject>Preadipocytes</subject><subject>Proteins</subject><subject>Ranunculaceae</subject><subject>Rats</subject><subject>Soybeans</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkt9rFDEQxxdRbKl98Q-QgC8ibN1kssnmRbjWO1soFEWfQzY7uUu9S-omW-x_b5bWsxWThwwzn_mS-VFVr2lzAqCaD2GinFEuOnhWHbJGsloIDs8f2QfVcUrXzXxkIwW8rA5AgOCKt4dVOPXRxnCLY8aBrMbJZ7L8lUdjM4mOLH5g7w35MvlgsimRje99TmQRsq-vekw-35Glc2iL0wdy7tebemUy-eQx1xdhmGyRnUEkX01Or6oXzmwTHj-8R9X31fLb2Xl9efX54mxxWVsuIddGddJZY1AwVMy0HZdUWHQScGAdVwaGFlEqRRX0iveqBJiDBqhFQx2Fo-rjve7N1O9wsBhKSVt9M_qdGe90NF4_jQS_0et4q5VoBWNQBN49CIzx54Qp651PFrdbEzBOSTMJbSc58K6gb_9Br-M0hlLeTJXJdKL8b0-tzRa1Dy7OTZ5F9UJyAayl0Bbq5D9UuQPufJkTOl_8TxLe3yfYMaY0otvXSBs9L4j-uyAFfvO4K3v0zzrAb0LBtE4</recordid><startdate>20221105</startdate><enddate>20221105</enddate><creator>Lee, Seul Gi</creator><creator>Lee, Eunbi</creator><creator>Chae, Jongbeom</creator><creator>Kim, Jin Soo</creator><creator>Lee, Han-Saem</creator><creator>Lim, Yu-Mi</creator><creator>So, Jai-Hyun</creator><creator>Hahn, Dongyup</creator><creator>Nam, Ju-Ock</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8186-0886</orcidid><orcidid>https://orcid.org/0000-0002-1300-0101</orcidid></search><sort><creationdate>20221105</creationdate><title>Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats</title><author>Lee, Seul Gi ; Lee, Eunbi ; Chae, Jongbeom ; Kim, Jin Soo ; Lee, Han-Saem ; Lim, Yu-Mi ; So, Jai-Hyun ; Hahn, Dongyup ; Nam, Ju-Ock</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-a987fcaae62e92a584716cef73ed2849a3d5ee799193b94b973e2f3031cea1f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>3T3-L1 Cells</topic><topic>Adipocytes</topic><topic>Adipogenesis</topic><topic>Adipose tissue</topic><topic>Akebia quinata</topic><topic>Animals</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>Bioactive compounds</topic><topic>Biocompatibility</topic><topic>Bioconversion</topic><topic>Biological activity</topic><topic>Biotransformation</topic><topic>Body fat</topic><topic>Care and treatment</topic><topic>Chemical properties</topic><topic>Chemical research</topic><topic>Cholesterol</topic><topic>Cytotoxicity</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Enzymes</topic><topic>Fruit</topic><topic>Fruits</topic><topic>Health aspects</topic><topic>High density lipoprotein</topic><topic>High fat diet</topic><topic>Insulin</topic><topic>Lipids</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Obesity - etiology</topic><topic>Oral administration</topic><topic>Plant Extracts - pharmacology</topic><topic>Preadipocytes</topic><topic>Proteins</topic><topic>Ranunculaceae</topic><topic>Rats</topic><topic>Soybeans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Seul Gi</creatorcontrib><creatorcontrib>Lee, Eunbi</creatorcontrib><creatorcontrib>Chae, Jongbeom</creatorcontrib><creatorcontrib>Kim, Jin Soo</creatorcontrib><creatorcontrib>Lee, Han-Saem</creatorcontrib><creatorcontrib>Lim, Yu-Mi</creatorcontrib><creatorcontrib>So, Jai-Hyun</creatorcontrib><creatorcontrib>Hahn, Dongyup</creatorcontrib><creatorcontrib>Nam, Ju-Ock</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Seul Gi</au><au>Lee, Eunbi</au><au>Chae, Jongbeom</au><au>Kim, Jin Soo</au><au>Lee, Han-Saem</au><au>Lim, Yu-Mi</au><au>So, Jai-Hyun</au><au>Hahn, Dongyup</au><au>Nam, Ju-Ock</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2022-11-05</date><risdate>2022</risdate><volume>14</volume><issue>21</issue><spage>4683</spage><pages>4683-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Akebia quinata, commonly called chocolate vine, has various bioactivities, including antioxidant and anti-obesity properties. However, the anti-obesity effects of bioconverted extracts of A. quinate have not been examined. In this study, A. quinata fruit extracts was bioconverted using the enzyme isolated from the soybean paste fungi Aspergillus kawachii. To determine whether the bioconversion process could influence the anti-obesity effects of A. quinata fruit extracts, we employed 3T3-L1 adipocytes and HFD-induced obese rats. We observed that the bioconverted fruit extract of A. quinata (BFE) afforded anti-obesity effects, which were stronger than that for the non-bioconverted fruit extract (FE) of A. quinata. In 3T3-L1 adipocytes, treatment with BFE at concentrations of 20 and 40 μg reduced intracellular lipids by 74.8 (p < 0.05) and 54.9% (p < 0.01), respectively, without inducing cytotoxicity in preadipocytes. Moreover, the oral administration of BFE at the concentration of 300 mg/kg/day significantly reduced body and adipose tissue weights (p < 0.01) in HFD-induced obese rats. Plasma cholesterol values were reduced, whereas HDL was increased in BFE receiving rats. Although FE could exert anti-obesity effects, BFE supplementation induced more robust effects than FE. These results could be attributed to the bioconversion-induced alteration of bioactive compound content within the extract.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36364945</pmid><doi>10.3390/nu14214683</doi><orcidid>https://orcid.org/0000-0001-8186-0886</orcidid><orcidid>https://orcid.org/0000-0002-1300-0101</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6643 |
| ispartof | Nutrients, 2022-11, Vol.14 (21), p.4683 |
| issn | 2072-6643 2072-6643 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9656223 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | 3T3-L1 Cells Adipocytes Adipogenesis Adipose tissue Akebia quinata Animals Anti-Obesity Agents - pharmacology Bioactive compounds Biocompatibility Bioconversion Biological activity Biotransformation Body fat Care and treatment Chemical properties Chemical research Cholesterol Cytotoxicity Diet Diet, High-Fat - adverse effects Enzymes Fruit Fruits Health aspects High density lipoprotein High fat diet Insulin Lipids Mice Mice, Inbred C57BL Obesity Obesity - drug therapy Obesity - etiology Oral administration Plant Extracts - pharmacology Preadipocytes Proteins Ranunculaceae Rats Soybeans |
| title | Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T19%3A34%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bioconverted%20Fruit%20Extract%20of%20Akebia%20Quinata%20Exhibits%20Anti-Obesity%20Effects%20in%20High-Fat%20Diet-Induced%20Obese%20Rats&rft.jtitle=Nutrients&rft.au=Lee,%20Seul%20Gi&rft.date=2022-11-05&rft.volume=14&rft.issue=21&rft.spage=4683&rft.pages=4683-&rft.issn=2072-6643&rft.eissn=2072-6643&rft_id=info:doi/10.3390/nu14214683&rft_dat=%3Cgale_pubme%3EA746325135%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2734688697&rft_id=info:pmid/36364945&rft_galeid=A746325135&rfr_iscdi=true |