Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance
All aspects of prostate cancer evolution are closely related to androgen levels and the status of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways and AR, from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC). Alterations...
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| Veröffentlicht in: | International journal of molecular sciences 2022-11, Vol.23 (21), p.13521 |
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| container_issue | 21 |
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| container_title | International journal of molecular sciences |
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| creator | Zhang, Haozhe Zhou, Yi Xing, Zengzhen Sah, Rajiv Kumar Hu, Junqi Hu, Hailiang |
| description | All aspects of prostate cancer evolution are closely related to androgen levels and the status of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways and AR, from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC). Alterations in androgen metabolism and its response are one of the main reasons for prostate cancer drug resistance. In this review, we will introduce androgen metabolism, including how the androgen was synthesized, consumed, and responded to in healthy people and prostate cancer patients, and discuss how these alterations in androgen metabolism contribute to the resistance to anti-androgen therapy. |
| doi_str_mv | 10.3390/ijms232113521 |
| format | Article |
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Almost all treatments target androgen metabolism pathways and AR, from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC). Alterations in androgen metabolism and its response are one of the main reasons for prostate cancer drug resistance. In this review, we will introduce androgen metabolism, including how the androgen was synthesized, consumed, and responded to in healthy people and prostate cancer patients, and discuss how these alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms232113521</identifier><identifier>PMID: 36362304</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Adrenal glands ; Androgen receptors ; Androgens ; Biosynthesis ; Cancer therapies ; Carbon ; Castration ; Cholesterol ; Drug resistance ; Endoplasmic reticulum ; Enzymes ; Hyperplasia ; Metabolism ; Metastasis ; Prostate cancer ; Review ; Steroids ; Testosterone</subject><ispartof>International journal of molecular sciences, 2022-11, Vol.23 (21), p.13521</ispartof><rights>2022 by the authors. 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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adrenal glands Androgen receptors Androgens Biosynthesis Cancer therapies Carbon Castration Cholesterol Drug resistance Endoplasmic reticulum Enzymes Hyperplasia Metabolism Metastasis Prostate cancer Review Steroids Testosterone |
| title | Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance |
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