The Role of Catechins in Regulating Diabetes: An Update Review
Catechins are key functional components in tea and have many health benefits, including relieving diabetes. Glucose is necessary for maintaining life. However, when the glucose in the serum exceeds the threshold, it will lead to hyperglycemia. Hyperglycemia is mainly caused by insufficient insulin s...
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| Veröffentlicht in: | Nutrients 2022-11, Vol.14 (21), p.4681 |
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| creator | Wen, Lianghua Wu, Dan Tan, Xindong Zhong, Meiqi Xing, Jiabao Li, Wei Li, Dan Cao, Fanrong |
| description | Catechins are key functional components in tea and have many health benefits, including relieving diabetes. Glucose is necessary for maintaining life. However, when the glucose in the serum exceeds the threshold, it will lead to hyperglycemia. Hyperglycemia is mainly caused by insufficient insulin secretion or insulin resistance. Persistent hyperglycemia can cause various disorders, including retinopathy, nephropathy, neurodegenerative diseases, cardiovascular disease, and diabetes. In this paper, we summarize the research on the underlying mechanisms of catechins in regulating diabetes and elaborate on the mechanisms of catechins in alleviating hyperglycemia by improving insulin resistance, alleviating oxidative stress, regulating mitochondrial function, alleviating endoplasmic reticulum stress, producing anti-inflammatory effects, reducing blood sugar source, and regulating intestinal function. This review will provide scientific direction for future research on catechin alleviating diabetes. |
| doi_str_mv | 10.3390/nu14214681 |
| format | Article |
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Glucose is necessary for maintaining life. However, when the glucose in the serum exceeds the threshold, it will lead to hyperglycemia. Hyperglycemia is mainly caused by insufficient insulin secretion or insulin resistance. Persistent hyperglycemia can cause various disorders, including retinopathy, nephropathy, neurodegenerative diseases, cardiovascular disease, and diabetes. In this paper, we summarize the research on the underlying mechanisms of catechins in regulating diabetes and elaborate on the mechanisms of catechins in alleviating hyperglycemia by improving insulin resistance, alleviating oxidative stress, regulating mitochondrial function, alleviating endoplasmic reticulum stress, producing anti-inflammatory effects, reducing blood sugar source, and regulating intestinal function. This review will provide scientific direction for future research on catechin alleviating diabetes.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu14214681</identifier><identifier>PMID: 36364943</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Adipocytes ; Antioxidants ; Blood sugar ; Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Catechin ; Diabetes ; Diabetes mellitus ; Endoplasmic reticulum ; Enzymes ; Glucose ; Health aspects ; Hyperglycemia ; Inflammation ; Insulin ; Insulin resistance ; Insulin secretion ; Insulin-like growth factors ; Kinases ; Metabolism ; Metabolites ; Mitochondria ; Nephropathy ; Nervous system diseases ; Obesity ; Oxidation resistance ; Oxidative stress ; Phosphorylation ; Physiological aspects ; Polyphenols ; Retinopathy ; Review ; Signal transduction ; Tea</subject><ispartof>Nutrients, 2022-11, Vol.14 (21), p.4681</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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This review will provide scientific direction for future research on catechin alleviating diabetes.</description><subject>Adipocytes</subject><subject>Antioxidants</subject><subject>Blood sugar</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Catechin</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Endoplasmic reticulum</subject><subject>Enzymes</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Hyperglycemia</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Insulin secretion</subject><subject>Insulin-like growth factors</subject><subject>Kinases</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Mitochondria</subject><subject>Nephropathy</subject><subject>Nervous system diseases</subject><subject>Obesity</subject><subject>Oxidation resistance</subject><subject>Oxidative stress</subject><subject>Phosphorylation</subject><subject>Physiological aspects</subject><subject>Polyphenols</subject><subject>Retinopathy</subject><subject>Review</subject><subject>Signal transduction</subject><subject>Tea</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkd9rGzEMx81YaUvbl_4FB3sZg7S25bPPeyiErL-gUCjJs7HvdInDxc7Odx377-fQ0qaj0oOE9NFXCBFyzugFgKaXYWSCMyEr9oUcc6r4REoBX_fyI3KW0pruTFEl4ZAcgQQptIBjcjVfYfEUOyxiW8zsgPXKh1T4UDzhcuzs4MOy-OWtwwHTz2IaisW2yVhuP3v8c0oOWtslPHuNJ2Rxcz2f3U0eHm_vZ9OHSS1KOkwQnUTndIVVSavSgdXKuhaEYk3pOOO1o7JROQJYW3GOWkJVMuEscw3VcEKuXnS3o9tgU2MYetuZbe83tv9rovXmYyf4lVnGZ6NlKTSnWeD7q0Aff4-YBrPxqcauswHjmAxXUFZKAFQZ_fYfuo5jH_J5O0pIzSXdo5a2Q-NDG_PeeidqpkpI4CUDyNTFJ1T2Bje-jgFbn-sfBn68DNR9TKnH9u1GRs3u4eb94fAPd8mYhQ</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Wen, Lianghua</creator><creator>Wu, Dan</creator><creator>Tan, Xindong</creator><creator>Zhong, Meiqi</creator><creator>Xing, Jiabao</creator><creator>Li, Wei</creator><creator>Li, Dan</creator><creator>Cao, Fanrong</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8041-4016</orcidid></search><sort><creationdate>20221101</creationdate><title>The Role of Catechins in Regulating Diabetes: An Update Review</title><author>Wen, Lianghua ; 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Glucose is necessary for maintaining life. However, when the glucose in the serum exceeds the threshold, it will lead to hyperglycemia. Hyperglycemia is mainly caused by insufficient insulin secretion or insulin resistance. Persistent hyperglycemia can cause various disorders, including retinopathy, nephropathy, neurodegenerative diseases, cardiovascular disease, and diabetes. In this paper, we summarize the research on the underlying mechanisms of catechins in regulating diabetes and elaborate on the mechanisms of catechins in alleviating hyperglycemia by improving insulin resistance, alleviating oxidative stress, regulating mitochondrial function, alleviating endoplasmic reticulum stress, producing anti-inflammatory effects, reducing blood sugar source, and regulating intestinal function. This review will provide scientific direction for future research on catechin alleviating diabetes.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>36364943</pmid><doi>10.3390/nu14214681</doi><orcidid>https://orcid.org/0000-0001-8041-4016</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes Antioxidants Blood sugar Cardiovascular disease Cardiovascular diseases Care and treatment Catechin Diabetes Diabetes mellitus Endoplasmic reticulum Enzymes Glucose Health aspects Hyperglycemia Inflammation Insulin Insulin resistance Insulin secretion Insulin-like growth factors Kinases Metabolism Metabolites Mitochondria Nephropathy Nervous system diseases Obesity Oxidation resistance Oxidative stress Phosphorylation Physiological aspects Polyphenols Retinopathy Review Signal transduction Tea |
| title | The Role of Catechins in Regulating Diabetes: An Update Review |
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