The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta
The chemical element selenium (Se) is a nonmetal that is in trace amounts indispensable for normal cellular functioning. During pregnancy, a low Se status can increase the risk of oxidative stress. However, elevated concentrations of Se in the body can also cause oxidative stress. This study aimed t...
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| Veröffentlicht in: | International journal of molecular sciences 2022-10, Vol.23 (21), p.13068 |
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| creator | Manojlović-Stojanoski, Milica Borković-Mitić, Slavica Nestorović, Nataša Ristić, Nataša Trifunović, Svetlana Stevanović, Magdalena Filipović, Nenad Stojsavljević, Aleksandar Pavlović, Slađan |
| description | The chemical element selenium (Se) is a nonmetal that is in trace amounts indispensable for normal cellular functioning. During pregnancy, a low Se status can increase the risk of oxidative stress. However, elevated concentrations of Se in the body can also cause oxidative stress. This study aimed to compare the effects of BSA-stabilized Se nanoparticles (SeNPs, Se
) (BSA-bovine serum albumin) and inorganic sodium selenite (NaSe, Se
) supplementation on the histological structure of the placenta, oxidative stress parameters and the total placental Se concentration of Wistar rats during pregnancy. Pregnant females were randomized into four groups: (i) intact controls; (ii) controls that were dosed by daily oral gavage with 8.6% bovine serum albumin (BSA) and 0.125 M vit C; (iii) the SeNP group that was administered 0.5 mg of SeNPs stabilized with 8.6% BSA and 0.125 M vit C/kg bw/day by oral gavage dosing; (iv) the NaSe group, gavage dosed with 0.5 mg Na
SeO
/kg bw/day. The treatment of pregnant females started on gestational day one, lasted until day 20, and on day 21 of gestation, the fetuses with the placenta were removed from the uterus. Our findings show that the mode of action of equivalent concentrations of Se in SeNPs and NaSe depended on its redox state and chemical structure. Administration of SeNPs (Se
) increased fetal lethality and induced changes in the antioxidative defense parameters in the placenta. The accumulation of Se in the placenta was highest in SeNP-treated animals. All obtained data indicate an increased bioavailability of Se in its organic nano form and Se
redox state in comparison to its inorganic sodium selenite form and Se
redox state. |
| doi_str_mv | 10.3390/ijms232113068 |
| format | Article |
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) (BSA-bovine serum albumin) and inorganic sodium selenite (NaSe, Se
) supplementation on the histological structure of the placenta, oxidative stress parameters and the total placental Se concentration of Wistar rats during pregnancy. Pregnant females were randomized into four groups: (i) intact controls; (ii) controls that were dosed by daily oral gavage with 8.6% bovine serum albumin (BSA) and 0.125 M vit C; (iii) the SeNP group that was administered 0.5 mg of SeNPs stabilized with 8.6% BSA and 0.125 M vit C/kg bw/day by oral gavage dosing; (iv) the NaSe group, gavage dosed with 0.5 mg Na
SeO
/kg bw/day. The treatment of pregnant females started on gestational day one, lasted until day 20, and on day 21 of gestation, the fetuses with the placenta were removed from the uterus. Our findings show that the mode of action of equivalent concentrations of Se in SeNPs and NaSe depended on its redox state and chemical structure. Administration of SeNPs (Se
) increased fetal lethality and induced changes in the antioxidative defense parameters in the placenta. The accumulation of Se in the placenta was highest in SeNP-treated animals. All obtained data indicate an increased bioavailability of Se in its organic nano form and Se
redox state in comparison to its inorganic sodium selenite form and Se
redox state.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms232113068</identifier><identifier>PMID: 36361856</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Antioxidants ; Bioavailability ; Biology ; Bovine serum albumin ; Cattle ; Dietary Supplements ; Female ; Fetuses ; Miscarriage ; Mothers ; Nanoparticles ; Nanoparticles - chemistry ; Oxidation ; Oxidation-Reduction ; Oxidative Stress ; Physiology ; Placenta ; Pregnancy ; Rats ; Rats, Wistar ; Redox properties ; Selenites ; Selenium ; Selenium - chemistry ; Serum albumin ; Serum Albumin, Bovine - pharmacology ; Sodium ; Sodium Selenite - pharmacology ; Thyroid gland ; Uterus</subject><ispartof>International journal of molecular sciences, 2022-10, Vol.23 (21), p.13068</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-cb7adf756c8e299f83e91499725c2a0f4812f4e094596f6cec54ac0d5a95daf13</citedby><cites>FETCH-LOGICAL-c415t-cb7adf756c8e299f83e91499725c2a0f4812f4e094596f6cec54ac0d5a95daf13</cites><orcidid>0000-0003-4895-9985 ; 0000-0001-6218-988X ; 0000-0003-2261-8066 ; 0000-0002-5651-7178 ; 0000-0002-3989-0237 ; 0000-0002-6221-3437</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654536/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654536/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36361856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manojlović-Stojanoski, Milica</creatorcontrib><creatorcontrib>Borković-Mitić, Slavica</creatorcontrib><creatorcontrib>Nestorović, Nataša</creatorcontrib><creatorcontrib>Ristić, Nataša</creatorcontrib><creatorcontrib>Trifunović, Svetlana</creatorcontrib><creatorcontrib>Stevanović, Magdalena</creatorcontrib><creatorcontrib>Filipović, Nenad</creatorcontrib><creatorcontrib>Stojsavljević, Aleksandar</creatorcontrib><creatorcontrib>Pavlović, Slađan</creatorcontrib><title>The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The chemical element selenium (Se) is a nonmetal that is in trace amounts indispensable for normal cellular functioning. During pregnancy, a low Se status can increase the risk of oxidative stress. However, elevated concentrations of Se in the body can also cause oxidative stress. This study aimed to compare the effects of BSA-stabilized Se nanoparticles (SeNPs, Se
) (BSA-bovine serum albumin) and inorganic sodium selenite (NaSe, Se
) supplementation on the histological structure of the placenta, oxidative stress parameters and the total placental Se concentration of Wistar rats during pregnancy. Pregnant females were randomized into four groups: (i) intact controls; (ii) controls that were dosed by daily oral gavage with 8.6% bovine serum albumin (BSA) and 0.125 M vit C; (iii) the SeNP group that was administered 0.5 mg of SeNPs stabilized with 8.6% BSA and 0.125 M vit C/kg bw/day by oral gavage dosing; (iv) the NaSe group, gavage dosed with 0.5 mg Na
SeO
/kg bw/day. The treatment of pregnant females started on gestational day one, lasted until day 20, and on day 21 of gestation, the fetuses with the placenta were removed from the uterus. Our findings show that the mode of action of equivalent concentrations of Se in SeNPs and NaSe depended on its redox state and chemical structure. Administration of SeNPs (Se
) increased fetal lethality and induced changes in the antioxidative defense parameters in the placenta. The accumulation of Se in the placenta was highest in SeNP-treated animals. All obtained data indicate an increased bioavailability of Se in its organic nano form and Se
redox state in comparison to its inorganic sodium selenite form and Se
redox state.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Bioavailability</subject><subject>Biology</subject><subject>Bovine serum albumin</subject><subject>Cattle</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Fetuses</subject><subject>Miscarriage</subject><subject>Mothers</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Physiology</subject><subject>Placenta</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Redox properties</subject><subject>Selenites</subject><subject>Selenium</subject><subject>Selenium - chemistry</subject><subject>Serum albumin</subject><subject>Serum Albumin, Bovine - pharmacology</subject><subject>Sodium</subject><subject>Sodium Selenite - pharmacology</subject><subject>Thyroid gland</subject><subject>Uterus</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkk1v1DAQhiMEomXhyBVZ4sKBgD9iJ74gtVX5kCpaNeUceZ1x65UTp7ZTtfwr_iEOu61aJEtj-X30zoxniuItwZ8Yk_iz3QyRMkoIw6J5VuyTitISY1E_f3TfK17FuME4g1y-LPaYYII0XOwXfy6uAB0bAzpF5A06bA_KNqm1dfY39KgFB6OdB_RTjX5SIVntICI1Zsn3i7AlEqB2niYHA4xJJetHlE_K3m0Ks05zgI_o9Nb2Wbv59wgxojMV1AAJws7xPtk59P4WHVrv_OUdsiM6VwmdOaUX89fFC6NchDe7uCp-fT2-OPpenpx--3F0cFLqivBU6nWtelNzoRugUpqGgSSVlDXlmipsqoZQUwGWFZfCCA2aV0rjnivJe2UIWxVftr7TvB6gX3IH5bop2EGFu84r2z1VRnvVXfqbTgpe8fzDq-LDziD46xli6gYbNTinRvBz7GjNeCMErpuMvv8P3fg5jLm9haoEaxinmSq3lA4-xgDmoRiCu2UZuifLkPl3jzt4oO-nz_4CxIu0Pg</recordid><startdate>20221028</startdate><enddate>20221028</enddate><creator>Manojlović-Stojanoski, Milica</creator><creator>Borković-Mitić, Slavica</creator><creator>Nestorović, Nataša</creator><creator>Ristić, Nataša</creator><creator>Trifunović, Svetlana</creator><creator>Stevanović, Magdalena</creator><creator>Filipović, Nenad</creator><creator>Stojsavljević, Aleksandar</creator><creator>Pavlović, Slađan</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4895-9985</orcidid><orcidid>https://orcid.org/0000-0001-6218-988X</orcidid><orcidid>https://orcid.org/0000-0003-2261-8066</orcidid><orcidid>https://orcid.org/0000-0002-5651-7178</orcidid><orcidid>https://orcid.org/0000-0002-3989-0237</orcidid><orcidid>https://orcid.org/0000-0002-6221-3437</orcidid></search><sort><creationdate>20221028</creationdate><title>The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta</title><author>Manojlović-Stojanoski, Milica ; Borković-Mitić, Slavica ; Nestorović, Nataša ; Ristić, Nataša ; Trifunović, Svetlana ; Stevanović, Magdalena ; Filipović, Nenad ; Stojsavljević, Aleksandar ; Pavlović, Slađan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-cb7adf756c8e299f83e91499725c2a0f4812f4e094596f6cec54ac0d5a95daf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Bioavailability</topic><topic>Biology</topic><topic>Bovine serum albumin</topic><topic>Cattle</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Fetuses</topic><topic>Miscarriage</topic><topic>Mothers</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Oxidation</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Physiology</topic><topic>Placenta</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Redox properties</topic><topic>Selenites</topic><topic>Selenium</topic><topic>Selenium - chemistry</topic><topic>Serum albumin</topic><topic>Serum Albumin, Bovine - pharmacology</topic><topic>Sodium</topic><topic>Sodium Selenite - pharmacology</topic><topic>Thyroid gland</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manojlović-Stojanoski, Milica</creatorcontrib><creatorcontrib>Borković-Mitić, Slavica</creatorcontrib><creatorcontrib>Nestorović, Nataša</creatorcontrib><creatorcontrib>Ristić, Nataša</creatorcontrib><creatorcontrib>Trifunović, Svetlana</creatorcontrib><creatorcontrib>Stevanović, Magdalena</creatorcontrib><creatorcontrib>Filipović, Nenad</creatorcontrib><creatorcontrib>Stojsavljević, Aleksandar</creatorcontrib><creatorcontrib>Pavlović, Slađan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manojlović-Stojanoski, Milica</au><au>Borković-Mitić, Slavica</au><au>Nestorović, Nataša</au><au>Ristić, Nataša</au><au>Trifunović, Svetlana</au><au>Stevanović, Magdalena</au><au>Filipović, Nenad</au><au>Stojsavljević, Aleksandar</au><au>Pavlović, Slađan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2022-10-28</date><risdate>2022</risdate><volume>23</volume><issue>21</issue><spage>13068</spage><pages>13068-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The chemical element selenium (Se) is a nonmetal that is in trace amounts indispensable for normal cellular functioning. During pregnancy, a low Se status can increase the risk of oxidative stress. However, elevated concentrations of Se in the body can also cause oxidative stress. This study aimed to compare the effects of BSA-stabilized Se nanoparticles (SeNPs, Se
) (BSA-bovine serum albumin) and inorganic sodium selenite (NaSe, Se
) supplementation on the histological structure of the placenta, oxidative stress parameters and the total placental Se concentration of Wistar rats during pregnancy. Pregnant females were randomized into four groups: (i) intact controls; (ii) controls that were dosed by daily oral gavage with 8.6% bovine serum albumin (BSA) and 0.125 M vit C; (iii) the SeNP group that was administered 0.5 mg of SeNPs stabilized with 8.6% BSA and 0.125 M vit C/kg bw/day by oral gavage dosing; (iv) the NaSe group, gavage dosed with 0.5 mg Na
SeO
/kg bw/day. The treatment of pregnant females started on gestational day one, lasted until day 20, and on day 21 of gestation, the fetuses with the placenta were removed from the uterus. Our findings show that the mode of action of equivalent concentrations of Se in SeNPs and NaSe depended on its redox state and chemical structure. Administration of SeNPs (Se
) increased fetal lethality and induced changes in the antioxidative defense parameters in the placenta. The accumulation of Se in the placenta was highest in SeNP-treated animals. All obtained data indicate an increased bioavailability of Se in its organic nano form and Se
redox state in comparison to its inorganic sodium selenite form and Se
redox state.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36361856</pmid><doi>10.3390/ijms232113068</doi><orcidid>https://orcid.org/0000-0003-4895-9985</orcidid><orcidid>https://orcid.org/0000-0001-6218-988X</orcidid><orcidid>https://orcid.org/0000-0003-2261-8066</orcidid><orcidid>https://orcid.org/0000-0002-5651-7178</orcidid><orcidid>https://orcid.org/0000-0002-3989-0237</orcidid><orcidid>https://orcid.org/0000-0002-6221-3437</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2022-10, Vol.23 (21), p.13068 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Antioxidants Bioavailability Biology Bovine serum albumin Cattle Dietary Supplements Female Fetuses Miscarriage Mothers Nanoparticles Nanoparticles - chemistry Oxidation Oxidation-Reduction Oxidative Stress Physiology Placenta Pregnancy Rats Rats, Wistar Redox properties Selenites Selenium Selenium - chemistry Serum albumin Serum Albumin, Bovine - pharmacology Sodium Sodium Selenite - pharmacology Thyroid gland Uterus |
| title | The Effects of BSA-Stabilized Selenium Nanoparticles and Sodium Selenite Supplementation on the Structure, Oxidative Stress Parameters and Selenium Redox Biology in Rat Placenta |
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