Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD

Background and Aims Bile acids are hepatic metabolites and have many properties considered to be relevant to the pathophysiology of NAFLD. Circulating levels of the intestinal microbiome‐modified bile acid deoxycholate are increased in cirrhosis. Approach and Results To further elucidate the role of...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2022-12, Vol.76 (6), p.1811-1824
Hauptverfasser:	Smirnova, Ekaterina, Muthiah, Mark D., Narayan, Nicole, Siddiqui, Mohamad S., Puri, Puneet, Luketic, Velimir A., Contos, Melissa J., Idowu, Michael, Chuang, Jen‐Chieh, Billin, Andrew N., Huss, Ryan S., Myers, Robert P., Boyett, Sherry, Seneshaw, Mulugeta, Min, Hae‐Ki, Mirshahi, Faridodin, Sanyal, Arun J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antibacterial activity Bile Bile acids Bile Acids and Salts - pharmacology Cirrhosis Clinical trials Deoxycholic acid Drug development Fibrosis Gastrointestinal Microbiome Hepatology Humans Hydrolase Intestinal microflora Intestine Liver Cirrhosis Metabolomics Microbiomes Non-alcoholic Fatty Liver Disease - metabolism Pathophysiology Phenotypes RNA, Ribosomal, 16S rRNA 16S Transcriptomics
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