Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury
— Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious organisms, toxins, and allergic stimuli, and maintenance of normal gaseous exchange and pulmonary function. The integrity of lung epithelium, fluid balance,...
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| Veröffentlicht in: | Inflammation 2022-12, Vol.45 (6), p.2142-2162 |
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| creator | Godbole, Nachiket M. Chowdhury, Asif Alam Chataut, Neha Awasthi, Shanjana |
| description | —
Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious organisms, toxins, and allergic stimuli, and maintenance of normal gaseous exchange and pulmonary function. The integrity of lung epithelium, fluid balance, and transport of molecules is dictated by the tight junctions (TJs). The TJs are formed between adjacent cells. We have focused on the topic of the TJ structure and function in lung epithelial cells. This review includes a summary of the last twenty years of literature reports published on the disrupted TJs and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli. We discuss the molecular signaling and crosstalk among signaling pathways that control the TJ structure and function. The Toll-like receptor-4 (TLR4) recognizes the pathogen- and damage-associated molecular patterns released during lung injury and inflammation and coordinates cellular responses. The molecular aspects of TLR4 signaling in the context of TJs or the epithelial barrier are not fully known. We describe the current knowledge and possible networking of the TLR4-signaling with cellular and molecular mechanisms of TJs, lung epithelial barrier function, and resistance to treatment strategies. |
| doi_str_mv | 10.1007/s10753-022-01708-y |
| format | Article |
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Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious organisms, toxins, and allergic stimuli, and maintenance of normal gaseous exchange and pulmonary function. The integrity of lung epithelium, fluid balance, and transport of molecules is dictated by the tight junctions (TJs). The TJs are formed between adjacent cells. We have focused on the topic of the TJ structure and function in lung epithelial cells. This review includes a summary of the last twenty years of literature reports published on the disrupted TJs and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli. We discuss the molecular signaling and crosstalk among signaling pathways that control the TJ structure and function. The Toll-like receptor-4 (TLR4) recognizes the pathogen- and damage-associated molecular patterns released during lung injury and inflammation and coordinates cellular responses. The molecular aspects of TLR4 signaling in the context of TJs or the epithelial barrier are not fully known. We describe the current knowledge and possible networking of the TLR4-signaling with cellular and molecular mechanisms of TJs, lung epithelial barrier function, and resistance to treatment strategies.</description><identifier>ISSN: 0360-3997</identifier><identifier>ISSN: 1573-2576</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-022-01708-y</identifier><identifier>PMID: 35779195</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adhesion ; Biomedical and Life Sciences ; Biomedicine ; Cytoskeleton ; Epithelial cells ; Epithelial Cells - metabolism ; Epithelium ; Epithelium - metabolism ; Health sciences ; Humans ; Immunology ; Internal Medicine ; Lung Injury - pathology ; Lungs ; Molecular modelling ; Pathogens ; Pathology ; Pharmaceutical sciences ; Pharmacology/Toxicology ; Pharmacy ; Proteins ; Respiratory function ; Review ; Rheumatology ; Signal transduction ; Structure-function relationships ; Surfactants ; Tight junctions ; Tight Junctions - metabolism ; TLR4 protein ; Toll-Like Receptor 4 - metabolism ; Toll-like receptors</subject><ispartof>Inflammation, 2022-12, Vol.45 (6), p.2142-2162</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ce3a15f7b4e48aa3f2f23ec3fe92768b6dc0ff4def1588ac373c378dd690d1f13</citedby><cites>FETCH-LOGICAL-c474t-ce3a15f7b4e48aa3f2f23ec3fe92768b6dc0ff4def1588ac373c378dd690d1f13</cites><orcidid>0000-0003-1249-0708</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-022-01708-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-022-01708-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35779195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Godbole, Nachiket M.</creatorcontrib><creatorcontrib>Chowdhury, Asif Alam</creatorcontrib><creatorcontrib>Chataut, Neha</creatorcontrib><creatorcontrib>Awasthi, Shanjana</creatorcontrib><title>Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>—
Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious organisms, toxins, and allergic stimuli, and maintenance of normal gaseous exchange and pulmonary function. The integrity of lung epithelium, fluid balance, and transport of molecules is dictated by the tight junctions (TJs). The TJs are formed between adjacent cells. We have focused on the topic of the TJ structure and function in lung epithelial cells. This review includes a summary of the last twenty years of literature reports published on the disrupted TJs and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli. We discuss the molecular signaling and crosstalk among signaling pathways that control the TJ structure and function. The Toll-like receptor-4 (TLR4) recognizes the pathogen- and damage-associated molecular patterns released during lung injury and inflammation and coordinates cellular responses. The molecular aspects of TLR4 signaling in the context of TJs or the epithelial barrier are not fully known. We describe the current knowledge and possible networking of the TLR4-signaling with cellular and molecular mechanisms of TJs, lung epithelial barrier function, and resistance to treatment strategies.</description><subject>Adhesion</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cytoskeleton</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelium</subject><subject>Epithelium - metabolism</subject><subject>Health sciences</subject><subject>Humans</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Lung Injury - pathology</subject><subject>Lungs</subject><subject>Molecular modelling</subject><subject>Pathogens</subject><subject>Pathology</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Proteins</subject><subject>Respiratory function</subject><subject>Review</subject><subject>Rheumatology</subject><subject>Signal transduction</subject><subject>Structure-function relationships</subject><subject>Surfactants</subject><subject>Tight junctions</subject><subject>Tight Junctions - metabolism</subject><subject>TLR4 protein</subject><subject>Toll-Like Receptor 4 - metabolism</subject><subject>Toll-like receptors</subject><issn>0360-3997</issn><issn>1573-2576</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1vVCEUhonR2LH6B1yYm7hxUZSvy8fGRNuqNZOYmHFNGC7MMDJwC_eazL8vdWr9WLiAs-A5LxweAJ5j9BojJN5UjERPISIEIiyQhIcHYIF7QSHpBX8IFohyBKlS4gQ8qXWHEJJK0sfghPZCKKz6BVitwmY7dZ_nZKeQUz3rpq3rLsfQSgwmdu9NKcGVs86koVvlGGEM31331Vk3TrlA1l3MJaRNt5zbdpV2czk8BY-8idU9u6un4NuHy9X5J7j88vHq_N0SWibYBK2jBvderJlj0hjqiSfUWeqdIoLLNR8s8p4NzuNeSmOpoG3JYeAKDdhjegreHnPHeb13g3VpKibqsYS9KQedTdB_n6Sw1Zv8QyvOlGSiBby6Cyj5enZ10vtQrYvRJJfnqgmXDClOGG3oy3_QXZ5LauNpIihjlCsmG0WOlC251uL8_WMw0rfS9FGabtL0T2n60Jpe_DnGfcsvSw2gR6COt1_tyu-7_xN7A0dRo6o</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Godbole, Nachiket M.</creator><creator>Chowdhury, Asif Alam</creator><creator>Chataut, Neha</creator><creator>Awasthi, Shanjana</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1249-0708</orcidid></search><sort><creationdate>20221201</creationdate><title>Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury</title><author>Godbole, Nachiket M. ; Chowdhury, Asif Alam ; Chataut, Neha ; Awasthi, Shanjana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ce3a15f7b4e48aa3f2f23ec3fe92768b6dc0ff4def1588ac373c378dd690d1f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adhesion</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cytoskeleton</topic><topic>Epithelial cells</topic><topic>Epithelial Cells - metabolism</topic><topic>Epithelium</topic><topic>Epithelium - metabolism</topic><topic>Health sciences</topic><topic>Humans</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Lung Injury - pathology</topic><topic>Lungs</topic><topic>Molecular modelling</topic><topic>Pathogens</topic><topic>Pathology</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Proteins</topic><topic>Respiratory function</topic><topic>Review</topic><topic>Rheumatology</topic><topic>Signal transduction</topic><topic>Structure-function relationships</topic><topic>Surfactants</topic><topic>Tight junctions</topic><topic>Tight Junctions - metabolism</topic><topic>TLR4 protein</topic><topic>Toll-Like Receptor 4 - metabolism</topic><topic>Toll-like receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Godbole, Nachiket M.</creatorcontrib><creatorcontrib>Chowdhury, Asif Alam</creatorcontrib><creatorcontrib>Chataut, Neha</creatorcontrib><creatorcontrib>Awasthi, Shanjana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Godbole, Nachiket M.</au><au>Chowdhury, Asif Alam</au><au>Chataut, Neha</au><au>Awasthi, Shanjana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>45</volume><issue>6</issue><spage>2142</spage><epage>2162</epage><pages>2142-2162</pages><issn>0360-3997</issn><issn>1573-2576</issn><eissn>1573-2576</eissn><abstract>—
Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious organisms, toxins, and allergic stimuli, and maintenance of normal gaseous exchange and pulmonary function. The integrity of lung epithelium, fluid balance, and transport of molecules is dictated by the tight junctions (TJs). The TJs are formed between adjacent cells. We have focused on the topic of the TJ structure and function in lung epithelial cells. This review includes a summary of the last twenty years of literature reports published on the disrupted TJs and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli. We discuss the molecular signaling and crosstalk among signaling pathways that control the TJ structure and function. The Toll-like receptor-4 (TLR4) recognizes the pathogen- and damage-associated molecular patterns released during lung injury and inflammation and coordinates cellular responses. The molecular aspects of TLR4 signaling in the context of TJs or the epithelial barrier are not fully known. We describe the current knowledge and possible networking of the TLR4-signaling with cellular and molecular mechanisms of TJs, lung epithelial barrier function, and resistance to treatment strategies.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35779195</pmid><doi>10.1007/s10753-022-01708-y</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0003-1249-0708</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Inflammation, 2022-12, Vol.45 (6), p.2142-2162 |
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| subjects | Adhesion Biomedical and Life Sciences Biomedicine Cytoskeleton Epithelial cells Epithelial Cells - metabolism Epithelium Epithelium - metabolism Health sciences Humans Immunology Internal Medicine Lung Injury - pathology Lungs Molecular modelling Pathogens Pathology Pharmaceutical sciences Pharmacology/Toxicology Pharmacy Proteins Respiratory function Review Rheumatology Signal transduction Structure-function relationships Surfactants Tight junctions Tight Junctions - metabolism TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors |
| title | Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury |
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