Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p

The canonical paradigm for converting genetic association to mechanism involves iteratively mapping individual associations to the proximal genes through which they act. In contrast, in the present study we demonstrate the feasibility of extracting biological insights from a very large region of the...

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Veröffentlicht in:	Nature genetics 2022-11, Vol.54 (11), p.1630-1639
Hauptverfasser:	Weiner, Daniel J., Ling, Emi, Erdin, Serkan, Tai, Derek J. C., Yadav, Rachita, Grove, Jakob, Fu, Jack M., Nadig, Ajay, Carey, Caitlin E., Baya, Nikolas, Bybjerg-Grauholm, Jonas, Berretta, Sabina, Macosko, Evan Z., Sebat, Jonathan, O’Connor, Luke J., Hougaard, David M., Børglum, Anders D., Talkowski, Michael E., McCarroll, Steven A., Robinson, Elise B.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/199 631/208/205/2138 631/208/212/177 631/208/366/1373 Agriculture Animal Genetics and Genomics Autism Autistic Disorder - genetics Biomedical and Life Sciences Biomedicine Cancer Research Chromatin Chromosome 16 Chromosome Deletion Chromosomes Chromosomes, Human, Pair 16 - genetics Consortia Convergence Copy number Data analysis DNA Copy Number Variations Feasibility studies Gene deletion Gene expression Gene Function Gene mapping Gene sequencing Genes Genomes Genomics Human Genetics Humans Influence Regions Statistics
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