MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells

•Low concentrations of miR-146b-5p have an adverse prognostic impact in CLL patients.•miR-146b-5p controls IL-23 stimulation of CLL cells by negatively regulating the expression of the IL-12Rβ1 chain of the IL-23R complex. [Display omitted] Chronic lymphocytic leukemia (CLL) cells express the interl...

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Veröffentlicht in:	Blood advances 2022-10, Vol.6 (20), p.5593-5612
Hauptverfasser:	Matis, Serena, Grazia Recchia, Anna, Colombo, Monica, Cardillo, Martina, Fabbi, Marina, Todoerti, Katia, Bossio, Sabrina, Fabris, Sonia, Cancila, Valeria, Massara, Rosanna, Reverberi, Daniele, Emionite, Laura, Cilli, Michele, Cerruti, Giannamaria, Salvi, Sandra, Bet, Paola, Pigozzi, Simona, Fiocca, Roberto, Ibatici, Adalberto, Angelucci, Emanuele, Gentile, Massimo, Monti, Paola, Menichini, Paola, Fronza, Gilberto, Torricelli, Federica, Ciarrocchi, Alessia, Neri, Antonino, Fais, Franco, Tripodo, Claudio, Morabito, Fortunato, Ferrarini, Manlio, Cutrona, Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD40 Ligand Interleukin-23 - genetics Leukemia, Lymphocytic, Chronic, B-Cell - genetics Mice MicroRNAs - genetics MicroRNAs - metabolism Receptors, Antigen, B-Cell Regular RNA, Messenger
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