Cell adhesion molecule CD44v10 promotes stem-like properties in triple-negative breast cancer cells via glucose transporter GLUT1-mediated glycolysis

Cell adhesion molecule CD44v8-10 is associated with tumor ste0mness and malignancy; however, whether CD44v10 alone confers these properties is unknown. Here, we demonstrated that CD44v10 promotes stemness and chemoresistance of triple-negative breast cancers (TNBCs) individually. Next, we identified...

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Veröffentlicht in:	The Journal of biological chemistry 2022-11, Vol.298 (11), p.102588-102588, Article 102588
Hauptverfasser:	Guo, Qian, Qiu, Yaqi, Liu, Yiwen, He, Yiqing, Zhang, Guoliang, Du, Yan, Yang, Cuixia, Gao, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	CD44v10 Cell Adhesion Molecules - metabolism Cell Line, Tumor Cell Proliferation Glucose Transport Proteins, Facilitative - metabolism Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism GLUT1 Glycolysis Humans Paclitaxel - pharmacology Phosphatidylinositol 3-Kinases - metabolism stem cell-like property Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism triple-negative breast cancer
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