The MDMX Acidic Domain Uses Allovalency to Bind Both p53 and MDMX

Autoinhibition of p53 binding to MDMX requires two short-linear motifs (SLiMs) containing adjacent tryptophan (WW) and tryptophan-phenylalanine (WF) residues. NMR spectroscopy was used to show the WW and WF motifs directly compete for the p53 binding site on MDMX and circular dichroism spectroscopy...

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Veröffentlicht in:	Journal of molecular biology 2022-11, Vol.434 (22), p.167844-167844, Article 167844
Hauptverfasser:	Fenton, Malissa, Borcherds, Wade, Chen, Lihong, Anbanandam, Asokan, Levy, Robin, Chen, Jiandong, Daughdrill, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Humans Phenylalanine - chemistry Protein Binding Protein Domains Proto-Oncogene Proteins c-mdm2 - chemistry Tryptophan - chemistry Tumor Suppressor Protein p53 - chemistry
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