Cryomicroscopy in situ : what is the smallest molecule that can be directly identified without labels in a cell?

Electron cryomicroscopy (cryoEM) has made great strides in the last decade, such that the atomic structure of most biological macromolecules can, at least in principle, be determined. Major technological advances - in electron imaging hardware, data analysis software, and cryogenic specimen preparat...

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Veröffentlicht in:	Faraday discussions 2022-11, Vol.240, p.277-302
Hauptverfasser:	Russo, Christopher J, Dickerson, Joshua L, Naydenova, Katerina
Format:	Artikel
Sprache:	eng
Schlagworte:	Atomic properties Atomic structure Chemistry Cryoelectron Microscopy - methods Data analysis Electron imaging Macromolecules Nucleic acids Proteins Questions Software Specimen preparation
Online-Zugang:	Volltext
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