Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial

Despite the availability of effective vaccines against COVID-19, booster vaccinations are needed to maintain vaccine-induced protection against variant strains and breakthrough infections. This study aimed to investigate the efficacy, safety, and immunogenicity of the Ad26.COV2.S vaccine (Janssen) a...

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Veröffentlicht in:	The Lancet infectious diseases 2022-12, Vol.22 (12), p.1703-1715
Hauptverfasser:	Hardt, Karin, Vandebosch, An, Sadoff, Jerald, Le Gars, Mathieu, Schuitemaker, Hanneke, Albertson, Timothy E., Velarde, Luis Humberto Anaya, Bhushanan, Jisha, Chen, Bohang, Chetty, Polan, Custers, Jerome, Delanghe, Hilde, Duca, Anna, Pinheiro, Jose, Roels, Sanne, Salas, Jose, Vaissiere, Nathalie, Xu, Jiajun, Goecker, Erin A., Takuva, Simbarashe G., Ahsan, Habibul, Bajwa, Ali, Berdaï, Driss, Biagioni Santos, Maria Silvia, Binnian, Ian, Bisnauthsing, Karen, Boivin, Jean-Marc, Botelho-Nevers, Elisabeth, Buntinx, Erik, Carr, Quito Osuna, Cereto Castro, Fernando, Chavoustie, Steven, D'Onofrio, Valentino, Dargan, Paul, Del Pozo, Jose Luis, Desai, Amisha, DiBuono, Mark, Duncan, Christopher, Elzi, Stanton, Emmett, Stevan, Evans, Mim, Farah, Theo, Floutier, Catherine, Flume, Patrick, Ford, Stacy, Garcia Diaz, Julia, Gardener, Zoe, Gauteul, Pascale, Gillet, Claudia, Go, Herschel Don D., Gokani, Karishma, Gonthier, Damien, Greenberg, Richard, Grobbelaar, Coert, Guancia, Adonis, Hakkarainen, Gloria, Hellstrom-Louw, Elizabeth, Hussen, Nazreen, Jackson, Yvonne, Jain, Manish, João Filho, Esaú Custódio, Jumeras, Analyn, Kimmel, Murray, Lazarus, Rajeka, Lins, Muriel, Maia, Bernardo Porto, Marín-Candon, Alícia, McCaughan, Frank, McCormack, Louise, McGettigan, John, Mehra, Purvi, Molto Marhuenda, Jose, Mullan, Daniel, Munro, Alasdair, Newman Lobato Souza, Tamara, Oliver, Abigail, Otero Romero, Susana, Pacurar, Mihaela, Pinto, S. Jerry, Presti, Rachel, Ramesh, Mayur, Riegel Santos, Breno, Riesenberg, Robert, Riffer, Ernie, Roche, Siobhan, Rose, Katie, Rosellini, Pietro, Rossignol, Patrick, Safirstein, Beth, Santhosh, Smrithi, Seco-Meseguer, Enrique, Seep, Michael, Short, Philip, Tellalian, David, Thiriphoo, Nang, Thomas, Judith, Thomas, Nicholas, Webster, Brian, Winston, Alan, Zervos, Marcus
Format:	Artikel
Sprache:	eng
Schlagworte:	Ad26COVS1 Adolescent Adult Adults Adverse events Algorithms Antibodies, Viral Coronaviruses COVID-19 COVID-19 - prevention & control COVID-19 vaccines COVID-19 Vaccines - adverse effects Double-Blind Method Double-blind studies Effectiveness Humans Immunogenicity Immunogenicity, Vaccine Immunology Infections Infectious diseases Laboratories Life Sciences mRNA vaccines Placebos Proteins R&D Research & development Safety SARS-CoV-2 Serology Severe acute respiratory syndrome coronavirus 2 Vaccine efficacy Vaccines Vaccinology
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