Epithelial sodium channels in macrophage migration and polarization: role of proinflammatory cytokines TNFα and IFNγ

Migration of monocytes-macrophages plays an important role in phagocytosis of pathogens and cellular debris in a variety of pathophysiological conditions. Although epithelial Na channels (ENaCs) are required for normal migratory responses in other cell types, their role in macrophage migration signa...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2022-11, Vol.323 (5), p.R763-R775
Hauptverfasser:	Nemeth, Zoltan, Hildebrandt, Emily, Parsa, Nicholas, Fleming, Adam B, Wasson, Robert, Pittman, Katarina, Bell, Xavier, Granger, Joey P, Ryan, Michael J, Drummond, Heather A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - pharmacology Animals Cytokines - metabolism Epithelial Sodium Channels - genetics Epithelial Sodium Channels - metabolism Humans Interferon-gamma - metabolism Interferon-gamma - pharmacology Macrophages - metabolism Mice Tumor Necrosis Factor-alpha - metabolism
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