Nucleus accumbens core and shell are differentially involved in general and outcome-specific forms of Pavlovian-instrumental transfer with alcohol and sucrose rewards
Alcohol‐associated stimuli contribute to relapse risk. Therefore, understanding the behavioural and neural mechanisms underlying the ability of such stimuli to promote alcohol‐seeking is important for developing effective treatments for alcohol‐use disorders. The Pavlovian‐instrumental transfer (PIT...
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description | Alcohol‐associated stimuli contribute to relapse risk. Therefore, understanding the behavioural and neural mechanisms underlying the ability of such stimuli to promote alcohol‐seeking is important for developing effective treatments for alcohol‐use disorders. The Pavlovian‐instrumental transfer (PIT) paradigm can be used to study the influence of Pavlovian cues on independently‐trained instrumental responses earning reward. The effects can be either general, increasing the vigour of reward‐related behaviours, or specific to responses that earn a common outcome. These different forms of PIT are mediated by distinct neural circuits involving the nucleus accumbens (NAC) core and shell, respectively. Here we examined the effects of pharmacological inactivation of either the NAC core or shell on PIT generated by alcohol‐predictive and sucrose‐predictive stimuli in rats. We found that presentations of a stimulus predicting sucrose enhanced responding for sucrose but not alcohol, suggesting an outcome‐specific effect. In contrast, presentations of an alcohol‐predictive stimulus enhanced responding for both alcohol and sucrose, suggesting a generally arousing effect. Inactivation of the NAC core reduced PIT and, in particular, the effect of the alcohol stimulus. Inactivation of the NAC shell reduced the specificity of the stimulus effects but left the ability of the stimuli to non‐specifically invigorate responding intact, consistent with a role in mediating the specificity of PIT. Together, these results suggest that the NAC core plays a particularly important role in mediating the influence of alcohol‐predictive cues on reward‐seeking behaviours.
We examined the effects of inactivation of the nucleus accumbens core or shell on Pavlovian‐instrumental transfer (PIT) generated by alcohol‐ and sucrose‐predictive stimuli. Inactivation of the NAC core reduced PIT and in particular, the effect of the alcohol stimulus. Inactivation of the NAC shell reduced the specificity of the stimulus effects but left the ability of the stimuli to non‐specifically invigorate responding intact consistent with a role in mediating the specificity of PIT. |
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We examined the effects of inactivation of the nucleus accumbens core or shell on Pavlovian‐instrumental transfer (PIT) generated by alcohol‐ and sucrose‐predictive stimuli. Inactivation of the NAC core reduced PIT and in particular, the effect of the alcohol stimulus. Inactivation of the NAC shell reduced the specificity of the stimulus effects but left the ability of the stimuli to non‐specifically invigorate responding intact consistent with a role in mediating the specificity of PIT.</description><identifier>ISSN: 0953-816X</identifier><identifier>ISSN: 1460-9568</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/ejn.13235</identifier><identifier>PMID: 26970240</identifier><language>eng</language><publisher>France: Blackwell Publishing Ltd</publisher><subject>Alcohol Drinking - physiopathology ; Animals ; Central Nervous System Depressants - pharmacology ; Conditioning, Classical ; Conditioning, Operant ; Ethanol - pharmacology ; incentive ; learning ; Male ; motivation ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - physiology ; rat ; Rats ; Rats, Long-Evans ; Reward ; stimulus ; Sucrose - pharmacology ; ventral striatum</subject><ispartof>The European journal of neuroscience, 2016-05, Vol.43 (9), p.1229-1236</ispartof><rights>2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd</rights><rights>2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4865-e50ab25381ef3a4681c38a48b69eb7fb1188afb4fafd174184e84ab5771379fd3</citedby><cites>FETCH-LOGICAL-c4865-e50ab25381ef3a4681c38a48b69eb7fb1188afb4fafd174184e84ab5771379fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejn.13235$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejn.13235$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26970240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dalley, Jeffrey</contributor><contributor>Dalley, Jeffrey</contributor><creatorcontrib>Corbit, Laura H.</creatorcontrib><creatorcontrib>Fischbach, Sarah C.</creatorcontrib><creatorcontrib>Janak, Patricia H.</creatorcontrib><title>Nucleus accumbens core and shell are differentially involved in general and outcome-specific forms of Pavlovian-instrumental transfer with alcohol and sucrose rewards</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>Alcohol‐associated stimuli contribute to relapse risk. Therefore, understanding the behavioural and neural mechanisms underlying the ability of such stimuli to promote alcohol‐seeking is important for developing effective treatments for alcohol‐use disorders. The Pavlovian‐instrumental transfer (PIT) paradigm can be used to study the influence of Pavlovian cues on independently‐trained instrumental responses earning reward. The effects can be either general, increasing the vigour of reward‐related behaviours, or specific to responses that earn a common outcome. These different forms of PIT are mediated by distinct neural circuits involving the nucleus accumbens (NAC) core and shell, respectively. Here we examined the effects of pharmacological inactivation of either the NAC core or shell on PIT generated by alcohol‐predictive and sucrose‐predictive stimuli in rats. We found that presentations of a stimulus predicting sucrose enhanced responding for sucrose but not alcohol, suggesting an outcome‐specific effect. In contrast, presentations of an alcohol‐predictive stimulus enhanced responding for both alcohol and sucrose, suggesting a generally arousing effect. Inactivation of the NAC core reduced PIT and, in particular, the effect of the alcohol stimulus. Inactivation of the NAC shell reduced the specificity of the stimulus effects but left the ability of the stimuli to non‐specifically invigorate responding intact, consistent with a role in mediating the specificity of PIT. Together, these results suggest that the NAC core plays a particularly important role in mediating the influence of alcohol‐predictive cues on reward‐seeking behaviours.
We examined the effects of inactivation of the nucleus accumbens core or shell on Pavlovian‐instrumental transfer (PIT) generated by alcohol‐ and sucrose‐predictive stimuli. Inactivation of the NAC core reduced PIT and in particular, the effect of the alcohol stimulus. Inactivation of the NAC shell reduced the specificity of the stimulus effects but left the ability of the stimuli to non‐specifically invigorate responding intact consistent with a role in mediating the specificity of PIT.</description><subject>Alcohol Drinking - physiopathology</subject><subject>Animals</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Conditioning, Classical</subject><subject>Conditioning, Operant</subject><subject>Ethanol - pharmacology</subject><subject>incentive</subject><subject>learning</subject><subject>Male</subject><subject>motivation</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - physiology</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Reward</subject><subject>stimulus</subject><subject>Sucrose - pharmacology</subject><subject>ventral striatum</subject><issn>0953-816X</issn><issn>1460-9568</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1uEzEUhUcIREthwQsgL2ExrR3_zgYJVaX8VAGJIBAby-O5blw842DPJOSFeE7cpo1ggYQ3tuVzPt1zfavqKcHHpKwTuBqOCZ1Rfq86JEzguuFC3a8OccNprYj4elA9yvkKY6wE4w-rg5loJJ4xfFj9mk82wJSRsXbqWxgysjEBMkOH8hJCQKbcOu8cJBhGb0LYIj-sY1hDVw7oEgZIJtwY4jTa2EOdV2C98xa5mPqMokMfzTrEtTdD7Yc8pqkvrGIakxlyIaONH5fIBBuXcYfKk00xA0qwManLj6sHzoQMT273o-rz67PF6Zv64sP529NXF7VlSvAaODbtjFNFwFHDhCKWKsNUKxpopWsJUcq4ljnjOiIZUQwUMy2XklDZuI4eVS933NXU9tDZUmYJp1fJ9yZtdTRe__0y-KW-jGvdCKoaIQvg-S0gxR8T5FH3PtvSRzNAnLImUslG4Ub-l5RJxrlgRfpiJ71uSk7g9hURrK9HQJcR0DcjULTP_oywV979eRGc7AQbH2D7b5I-eze_Q9Y7h88j_Nw7TPquS2TJ9Zf5uaaL97NFQ7_pT_Q32RHP2g</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Corbit, Laura H.</creator><creator>Fischbach, Sarah C.</creator><creator>Janak, Patricia H.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201605</creationdate><title>Nucleus accumbens core and shell are differentially involved in general and outcome-specific forms of Pavlovian-instrumental transfer with alcohol and sucrose rewards</title><author>Corbit, Laura H. ; Fischbach, Sarah C. ; Janak, Patricia H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4865-e50ab25381ef3a4681c38a48b69eb7fb1188afb4fafd174184e84ab5771379fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alcohol Drinking - physiopathology</topic><topic>Animals</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Conditioning, Classical</topic><topic>Conditioning, Operant</topic><topic>Ethanol - pharmacology</topic><topic>incentive</topic><topic>learning</topic><topic>Male</topic><topic>motivation</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - physiology</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Reward</topic><topic>stimulus</topic><topic>Sucrose - pharmacology</topic><topic>ventral striatum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corbit, Laura H.</creatorcontrib><creatorcontrib>Fischbach, Sarah C.</creatorcontrib><creatorcontrib>Janak, Patricia H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corbit, Laura H.</au><au>Fischbach, Sarah C.</au><au>Janak, Patricia H.</au><au>Dalley, Jeffrey</au><au>Dalley, Jeffrey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleus accumbens core and shell are differentially involved in general and outcome-specific forms of Pavlovian-instrumental transfer with alcohol and sucrose rewards</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2016-05</date><risdate>2016</risdate><volume>43</volume><issue>9</issue><spage>1229</spage><epage>1236</epage><pages>1229-1236</pages><issn>0953-816X</issn><issn>1460-9568</issn><eissn>1460-9568</eissn><abstract>Alcohol‐associated stimuli contribute to relapse risk. Therefore, understanding the behavioural and neural mechanisms underlying the ability of such stimuli to promote alcohol‐seeking is important for developing effective treatments for alcohol‐use disorders. The Pavlovian‐instrumental transfer (PIT) paradigm can be used to study the influence of Pavlovian cues on independently‐trained instrumental responses earning reward. The effects can be either general, increasing the vigour of reward‐related behaviours, or specific to responses that earn a common outcome. These different forms of PIT are mediated by distinct neural circuits involving the nucleus accumbens (NAC) core and shell, respectively. Here we examined the effects of pharmacological inactivation of either the NAC core or shell on PIT generated by alcohol‐predictive and sucrose‐predictive stimuli in rats. We found that presentations of a stimulus predicting sucrose enhanced responding for sucrose but not alcohol, suggesting an outcome‐specific effect. In contrast, presentations of an alcohol‐predictive stimulus enhanced responding for both alcohol and sucrose, suggesting a generally arousing effect. Inactivation of the NAC core reduced PIT and, in particular, the effect of the alcohol stimulus. Inactivation of the NAC shell reduced the specificity of the stimulus effects but left the ability of the stimuli to non‐specifically invigorate responding intact, consistent with a role in mediating the specificity of PIT. Together, these results suggest that the NAC core plays a particularly important role in mediating the influence of alcohol‐predictive cues on reward‐seeking behaviours.
We examined the effects of inactivation of the nucleus accumbens core or shell on Pavlovian‐instrumental transfer (PIT) generated by alcohol‐ and sucrose‐predictive stimuli. Inactivation of the NAC core reduced PIT and in particular, the effect of the alcohol stimulus. Inactivation of the NAC shell reduced the specificity of the stimulus effects but left the ability of the stimuli to non‐specifically invigorate responding intact consistent with a role in mediating the specificity of PIT.</abstract><cop>France</cop><pub>Blackwell Publishing Ltd</pub><pmid>26970240</pmid><doi>10.1111/ejn.13235</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Alcohol Drinking - physiopathology Animals Central Nervous System Depressants - pharmacology Conditioning, Classical Conditioning, Operant Ethanol - pharmacology incentive learning Male motivation Nucleus Accumbens - drug effects Nucleus Accumbens - physiology rat Rats Rats, Long-Evans Reward stimulus Sucrose - pharmacology ventral striatum |
title | Nucleus accumbens core and shell are differentially involved in general and outcome-specific forms of Pavlovian-instrumental transfer with alcohol and sucrose rewards |
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