A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KV11.1 (hERG) Variants

Loss-of-function (LOF) variants in the KV11.1 potassium channel cause long QT syndrome (LQTS). Most variants disrupt intracellular channel transport (trafficking) to the cell membrane. Since some channel inhibitors improve trafficking of KV11.1 variants, a high-throughput screening (HTS) assay to de...

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Veröffentlicht in:	Molecular pharmacology 2022-04, Vol.101 (4), p.236-245
Hauptverfasser:	Egly, Christian L., Blackwell, Daniel J., Schmeckpeper, Jeffrey, Delisle, Brian P., Weaver, C. David, Knollmann, Björn C.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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