Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering

Organophosphorus (OP) compounds, including nerve agents and some pesticides, covalently bind to the catalytic serine of human acetylcholinesterase (hAChE), thereby inhibiting acetylcholine hydrolysis necessary for efficient neurotransmission. Oxime antidotes can reactivate the OP-conjugated hAChE, b...

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Veröffentlicht in:	Structure (London) 2022-11, Vol.30 (11), p.1538-1549.e3
Hauptverfasser:	Gerlits, Oksana, Fajer, Mikolai, Cheng, Xiaolin, Blumenthal, Donald K., Radić, Zoran, Kovalevsky, Andrey
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES hAChE inelastic neutron scattering oxime reactivator paraoxon vibrational dynamics X-ray diffraction
Online-Zugang:	Volltext
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