Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules

Vitamin D metabolism centers on kidney regulation of Cyp27b1 by mineralotropic hormones, including induction by parathyroid hormone (PTH), suppression by fibroblast growth factor 23 (FGF23) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), and reciprocal regulations for Cyp24a1. This coordinated genomic r...

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Veröffentlicht in:	The Journal of biological chemistry 2022-11, Vol.298 (11), p.102559-102559, Article 102559
Hauptverfasser:	Meyer, Mark B., Benkusky, Nancy A., Lee, Seong Min, Yoon, Sung-Hee, Mannstadt, Michael, Wein, Marc N., Pike, J. Wesley
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25(OH)2D3 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Animals Calcitriol - metabolism ChIP-Seq Cyp24a1 Cyp27b1 cytochrome P450 FGF23 Fibroblast Growth Factors - metabolism gene regulation Genomics Kidney - metabolism Mice parathyroid hormone Parathyroid Hormone - metabolism Receptors, Calcitriol - metabolism salt-inducible kinases vitamin D Vitamin D - metabolism Vitamin D3 24-Hydroxylase - genetics
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