O -GlcNAcylation Coordinates Glutaminolysis by Regulating the Stability and Membrane Trafficking of ASCT2 in Hepatic Stellate Cells

Background and AimsRecognition of excessive activation of hepatic stellate cells (HSCs) in liver fibrosis prompted us to investigate the regulatory mechanisms of HSCs. We aimed to examine the role of O-GlcNAcylation modification of alanine, serine, cysteine transporter 2 (ASCT2) in HSCs and liver fi...

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Veröffentlicht in:Journal of clinical and translational hepatology 2022-03, Vol.10 (6), p.1107-1116
Hauptverfasser: Wang, Feixia, Chen, Li, Zhang, Biyun, Li, Zhanghao, Shen, Min, Tang, Li, Zhang, Zili, Shao, Jiangjuan, Zhang, Feng, Zheng, Shizhong, Tan, Shanzhong
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Sprache:eng
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