The Glasgow Prognostic Score Before Curative Resection May Predict Postoperative Complications in Patients with Gastric Cancer
Purpose Despite improvements in surgical techniques and devices and perioperative care of gastric cancer (GC), the rate of postoperative complications still has not decreased. If patients at high risk for postoperative complications could be identified early using biomarkers, these complications mig...
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| Veröffentlicht in: | Journal of gastrointestinal cancer 2022-12, Vol.53 (4), p.908-914 |
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| container_title | Journal of gastrointestinal cancer |
| container_volume | 53 |
| creator | Shimoda, Yota Fujikawa, Hirohito Komori, Keisuke Watanabe, Hayato Takahashi, Kosuke Kano, Kazuki Yamada, Takanobu Shiozawa, Manabu Morinaga, Soichiro Katsumata, Kenji Tsuchida, Akihiko Ogata, Takashi Oshima, Takashi |
| description | Purpose
Despite improvements in surgical techniques and devices and perioperative care of gastric cancer (GC), the rate of postoperative complications still has not decreased. If patients at high risk for postoperative complications could be identified early using biomarkers, these complications might be reduced. In this study, we investigated usefulness of the preoperative Glasgow Prognostic Score (GPS) as a predictive factor for complications after surgery in patients with stage II/III GC.
Methods
This study retrospectively analyzed the outcomes of 424 patients who underwent curative surgery for pathological stage II/III GC from February 2007 to July 2019 at a single center. The GPS was assessed within 4 days before surgery. To identify independent risk factors for postoperative complications, univariate and multivariate analyses were performed using a Cox proportional hazards model.
Results
The numbers of patients with a GPS of 0, 1, and 2 were 357, 55, and 12, respectively. The rate of complications after surgery was significantly higher among patients with a GPS of 1 or 2 than among patients with a GPS of 0 (
p
= 0.008). Multivariate analysis identified a GPS of 1 or 2 as an independent predictive factor for postoperative complications (
p
= 0.037).
Conclusion
The preoperative GPS may be a useful predictive factor for postoperative complications in patients with stage II/III GC. Being aware of the risk of complications after surgery as indicated by the GPS before surgery may promote safe and minimally invasive surgery that we expect will improve outcomes in patients with a GPS of 1 or 2. |
| doi_str_mv | 10.1007/s12029-021-00689-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9630216</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2572530768</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-23491d755c0d5c2ef821e95656318c827326805b75e4a5c5f6f7833a0a56c5533</originalsourceid><addsrcrecordid>eNp9kUtrGzEUhUVoiN0kf6ArLbuZVI-RZrQptEPiFlJi8lgLWb5jy4wlV9IkZNPfHrk2gW66Ohf0nXPFPQh9ouSKEtJ8SZQRpirCaEWIbFWlTtCUqppWUnL54X1m7QR9TGlToFpQeoYmvKhSjZyiP49rwLPBpFV4wfMYVj6k7Cx-sCEC_g79XroxmuyeAd9DAptd8PiXeS04LJ3NeF4sYQdHpgvb3eCs2WMJO4_nZQSfE35xeY1nJuVYFnTGW4gX6LQ3Q4LLo56jp5vrx-5HdXs3-9l9u61szXiuGK8VXTZCWLIUlkHfMgpKSCE5bW3LGs5kS8SiEVAbYUUv-6bl3BAjpBWC83P09ZC7GxdbWNryn2gGvYtua-KrDsbpf1-8W-tVeNZK8nJfWQI-HwNi-D1CynrrkoVhMB7CmDQTDROcNLItKDugNoaUIvTvayjR--L0oThdgvXf4rQqJn4wpQL7FUS9CWP05Sb_c70B1uCb7A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2572530768</pqid></control><display><type>article</type><title>The Glasgow Prognostic Score Before Curative Resection May Predict Postoperative Complications in Patients with Gastric Cancer</title><source>Springer Nature - Complete Springer Journals</source><creator>Shimoda, Yota ; Fujikawa, Hirohito ; Komori, Keisuke ; Watanabe, Hayato ; Takahashi, Kosuke ; Kano, Kazuki ; Yamada, Takanobu ; Shiozawa, Manabu ; Morinaga, Soichiro ; Katsumata, Kenji ; Tsuchida, Akihiko ; Ogata, Takashi ; Oshima, Takashi</creator><creatorcontrib>Shimoda, Yota ; Fujikawa, Hirohito ; Komori, Keisuke ; Watanabe, Hayato ; Takahashi, Kosuke ; Kano, Kazuki ; Yamada, Takanobu ; Shiozawa, Manabu ; Morinaga, Soichiro ; Katsumata, Kenji ; Tsuchida, Akihiko ; Ogata, Takashi ; Oshima, Takashi</creatorcontrib><description>Purpose
Despite improvements in surgical techniques and devices and perioperative care of gastric cancer (GC), the rate of postoperative complications still has not decreased. If patients at high risk for postoperative complications could be identified early using biomarkers, these complications might be reduced. In this study, we investigated usefulness of the preoperative Glasgow Prognostic Score (GPS) as a predictive factor for complications after surgery in patients with stage II/III GC.
Methods
This study retrospectively analyzed the outcomes of 424 patients who underwent curative surgery for pathological stage II/III GC from February 2007 to July 2019 at a single center. The GPS was assessed within 4 days before surgery. To identify independent risk factors for postoperative complications, univariate and multivariate analyses were performed using a Cox proportional hazards model.
Results
The numbers of patients with a GPS of 0, 1, and 2 were 357, 55, and 12, respectively. The rate of complications after surgery was significantly higher among patients with a GPS of 1 or 2 than among patients with a GPS of 0 (
p
= 0.008). Multivariate analysis identified a GPS of 1 or 2 as an independent predictive factor for postoperative complications (
p
= 0.037).
Conclusion
The preoperative GPS may be a useful predictive factor for postoperative complications in patients with stage II/III GC. Being aware of the risk of complications after surgery as indicated by the GPS before surgery may promote safe and minimally invasive surgery that we expect will improve outcomes in patients with a GPS of 1 or 2.</description><identifier>ISSN: 1941-6628</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-021-00689-9</identifier><identifier>PMID: 34519976</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer Research ; Gastroenterology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Oncology ; Original Research ; Radiotherapy</subject><ispartof>Journal of gastrointestinal cancer, 2022-12, Vol.53 (4), p.908-914</ispartof><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-23491d755c0d5c2ef821e95656318c827326805b75e4a5c5f6f7833a0a56c5533</citedby><cites>FETCH-LOGICAL-c423t-23491d755c0d5c2ef821e95656318c827326805b75e4a5c5f6f7833a0a56c5533</cites><orcidid>0000-0001-5818-8649</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12029-021-00689-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12029-021-00689-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Shimoda, Yota</creatorcontrib><creatorcontrib>Fujikawa, Hirohito</creatorcontrib><creatorcontrib>Komori, Keisuke</creatorcontrib><creatorcontrib>Watanabe, Hayato</creatorcontrib><creatorcontrib>Takahashi, Kosuke</creatorcontrib><creatorcontrib>Kano, Kazuki</creatorcontrib><creatorcontrib>Yamada, Takanobu</creatorcontrib><creatorcontrib>Shiozawa, Manabu</creatorcontrib><creatorcontrib>Morinaga, Soichiro</creatorcontrib><creatorcontrib>Katsumata, Kenji</creatorcontrib><creatorcontrib>Tsuchida, Akihiko</creatorcontrib><creatorcontrib>Ogata, Takashi</creatorcontrib><creatorcontrib>Oshima, Takashi</creatorcontrib><title>The Glasgow Prognostic Score Before Curative Resection May Predict Postoperative Complications in Patients with Gastric Cancer</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><description>Purpose
Despite improvements in surgical techniques and devices and perioperative care of gastric cancer (GC), the rate of postoperative complications still has not decreased. If patients at high risk for postoperative complications could be identified early using biomarkers, these complications might be reduced. In this study, we investigated usefulness of the preoperative Glasgow Prognostic Score (GPS) as a predictive factor for complications after surgery in patients with stage II/III GC.
Methods
This study retrospectively analyzed the outcomes of 424 patients who underwent curative surgery for pathological stage II/III GC from February 2007 to July 2019 at a single center. The GPS was assessed within 4 days before surgery. To identify independent risk factors for postoperative complications, univariate and multivariate analyses were performed using a Cox proportional hazards model.
Results
The numbers of patients with a GPS of 0, 1, and 2 were 357, 55, and 12, respectively. The rate of complications after surgery was significantly higher among patients with a GPS of 1 or 2 than among patients with a GPS of 0 (
p
= 0.008). Multivariate analysis identified a GPS of 1 or 2 as an independent predictive factor for postoperative complications (
p
= 0.037).
Conclusion
The preoperative GPS may be a useful predictive factor for postoperative complications in patients with stage II/III GC. Being aware of the risk of complications after surgery as indicated by the GPS before surgery may promote safe and minimally invasive surgery that we expect will improve outcomes in patients with a GPS of 1 or 2.</description><subject>Cancer Research</subject><subject>Gastroenterology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Radiotherapy</subject><issn>1941-6628</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kUtrGzEUhUVoiN0kf6ArLbuZVI-RZrQptEPiFlJi8lgLWb5jy4wlV9IkZNPfHrk2gW66Ohf0nXPFPQh9ouSKEtJ8SZQRpirCaEWIbFWlTtCUqppWUnL54X1m7QR9TGlToFpQeoYmvKhSjZyiP49rwLPBpFV4wfMYVj6k7Cx-sCEC_g79XroxmuyeAd9DAptd8PiXeS04LJ3NeF4sYQdHpgvb3eCs2WMJO4_nZQSfE35xeY1nJuVYFnTGW4gX6LQ3Q4LLo56jp5vrx-5HdXs3-9l9u61szXiuGK8VXTZCWLIUlkHfMgpKSCE5bW3LGs5kS8SiEVAbYUUv-6bl3BAjpBWC83P09ZC7GxdbWNryn2gGvYtua-KrDsbpf1-8W-tVeNZK8nJfWQI-HwNi-D1CynrrkoVhMB7CmDQTDROcNLItKDugNoaUIvTvayjR--L0oThdgvXf4rQqJn4wpQL7FUS9CWP05Sb_c70B1uCb7A</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Shimoda, Yota</creator><creator>Fujikawa, Hirohito</creator><creator>Komori, Keisuke</creator><creator>Watanabe, Hayato</creator><creator>Takahashi, Kosuke</creator><creator>Kano, Kazuki</creator><creator>Yamada, Takanobu</creator><creator>Shiozawa, Manabu</creator><creator>Morinaga, Soichiro</creator><creator>Katsumata, Kenji</creator><creator>Tsuchida, Akihiko</creator><creator>Ogata, Takashi</creator><creator>Oshima, Takashi</creator><general>Springer US</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5818-8649</orcidid></search><sort><creationdate>20221201</creationdate><title>The Glasgow Prognostic Score Before Curative Resection May Predict Postoperative Complications in Patients with Gastric Cancer</title><author>Shimoda, Yota ; Fujikawa, Hirohito ; Komori, Keisuke ; Watanabe, Hayato ; Takahashi, Kosuke ; Kano, Kazuki ; Yamada, Takanobu ; Shiozawa, Manabu ; Morinaga, Soichiro ; Katsumata, Kenji ; Tsuchida, Akihiko ; Ogata, Takashi ; Oshima, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-23491d755c0d5c2ef821e95656318c827326805b75e4a5c5f6f7833a0a56c5533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cancer Research</topic><topic>Gastroenterology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimoda, Yota</creatorcontrib><creatorcontrib>Fujikawa, Hirohito</creatorcontrib><creatorcontrib>Komori, Keisuke</creatorcontrib><creatorcontrib>Watanabe, Hayato</creatorcontrib><creatorcontrib>Takahashi, Kosuke</creatorcontrib><creatorcontrib>Kano, Kazuki</creatorcontrib><creatorcontrib>Yamada, Takanobu</creatorcontrib><creatorcontrib>Shiozawa, Manabu</creatorcontrib><creatorcontrib>Morinaga, Soichiro</creatorcontrib><creatorcontrib>Katsumata, Kenji</creatorcontrib><creatorcontrib>Tsuchida, Akihiko</creatorcontrib><creatorcontrib>Ogata, Takashi</creatorcontrib><creatorcontrib>Oshima, Takashi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimoda, Yota</au><au>Fujikawa, Hirohito</au><au>Komori, Keisuke</au><au>Watanabe, Hayato</au><au>Takahashi, Kosuke</au><au>Kano, Kazuki</au><au>Yamada, Takanobu</au><au>Shiozawa, Manabu</au><au>Morinaga, Soichiro</au><au>Katsumata, Kenji</au><au>Tsuchida, Akihiko</au><au>Ogata, Takashi</au><au>Oshima, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Glasgow Prognostic Score Before Curative Resection May Predict Postoperative Complications in Patients with Gastric Cancer</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>53</volume><issue>4</issue><spage>908</spage><epage>914</epage><pages>908-914</pages><issn>1941-6628</issn><eissn>1941-6636</eissn><abstract>Purpose
Despite improvements in surgical techniques and devices and perioperative care of gastric cancer (GC), the rate of postoperative complications still has not decreased. If patients at high risk for postoperative complications could be identified early using biomarkers, these complications might be reduced. In this study, we investigated usefulness of the preoperative Glasgow Prognostic Score (GPS) as a predictive factor for complications after surgery in patients with stage II/III GC.
Methods
This study retrospectively analyzed the outcomes of 424 patients who underwent curative surgery for pathological stage II/III GC from February 2007 to July 2019 at a single center. The GPS was assessed within 4 days before surgery. To identify independent risk factors for postoperative complications, univariate and multivariate analyses were performed using a Cox proportional hazards model.
Results
The numbers of patients with a GPS of 0, 1, and 2 were 357, 55, and 12, respectively. The rate of complications after surgery was significantly higher among patients with a GPS of 1 or 2 than among patients with a GPS of 0 (
p
= 0.008). Multivariate analysis identified a GPS of 1 or 2 as an independent predictive factor for postoperative complications (
p
= 0.037).
Conclusion
The preoperative GPS may be a useful predictive factor for postoperative complications in patients with stage II/III GC. Being aware of the risk of complications after surgery as indicated by the GPS before surgery may promote safe and minimally invasive surgery that we expect will improve outcomes in patients with a GPS of 1 or 2.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34519976</pmid><doi>10.1007/s12029-021-00689-9</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5818-8649</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1941-6628 1941-6636 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Cancer Research Gastroenterology Internal Medicine Medicine Medicine & Public Health Oncology Original Research Radiotherapy |
| title | The Glasgow Prognostic Score Before Curative Resection May Predict Postoperative Complications in Patients with Gastric Cancer |
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