A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery

In skeletal muscle excitation-contraction (E-C) coupling, depolarization of the plasma membrane triggers Ca2+ release from the sarcoplasmic reticulum (SR), referred to as depolarization-induced Ca2+ release (DICR). DICR occurs through the type 1 ryanodine receptor (RyR1), which physically interacts...

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Veröffentlicht in:	The Journal of general physiology 2022-12, Vol.154 (12), p.1
Hauptverfasser:	Murayama, Takashi, Kurebayashi, Nagomi, Numaga-Tomita, Takuro, Kobayashi, Takuya, Okazaki, Satoru, Yamashiro, Kyosuke, Nakada, Tsutomu, Mori, Shuichi, Ishida, Ryosuke, Kagechika, Hiroyuki, Yamada, Mitsuhiko, Sakurai, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor proteins Calcium (extracellular) Calcium (reticular) Calcium - metabolism Calcium channels (voltage-gated) Calcium Channels, L-Type - metabolism Calcium imaging Calcium influx Cellular physiology Contaminants Depolarization Dihydropyridine Drug development Drug Discovery HEK293 Cells Humans Hyperthermia Ion Channels in Context Malignant hyperthermia Membrane potential Methods and Approaches Muscle contraction Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - metabolism Muscular Diseases - metabolism Musculoskeletal system Mutation Myopathy Myotubes Perchloric acid Potassium Ryanodine Receptor Calcium Release Channel - metabolism Ryanodine receptors Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Skeletal muscle
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