Oncometabolite d-2HG alters T cell metabolism to impair CD8 + T cell function

Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis through epigenetic alterations. The cancer cell-intrinsic effects of d-2HG are well understood, but its tumor cell-non...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2022-09, Vol.377 (6614), p.1519-1529
Hauptverfasser:	Notarangelo, Giulia, Spinelli, Jessica B, Perez, Elizabeth M, Baker, Gregory J, Kurmi, Kiran, Elia, Ilaria, Stopka, Sylwia A, Baquer, Gerard, Lin, Jia-Ren, Golby, Alexandra J, Joshi, Shakchhi, Baron, Heide F, Drijvers, Jefte M, Georgiev, Peter, Ringel, Alison E, Zaganjor, Elma, McBrayer, Samuel K, Sorger, Peter K, Sharpe, Arlene H, Wucherpfennig, Kai W, Santagata, Sandro, Agar, Nathalie Y R, Suvà, Mario L, Haigis, Marcia C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Carcinogenesis - genetics Carcinogenesis - metabolism CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell proliferation Cytokines Dehydrogenase Gain of Function Mutation Glucose metabolism Glutarates - metabolism Humans Immunosuppressive agents Interferon-gamma - metabolism Isocitrate dehydrogenase Isocitrate Dehydrogenase - genetics Isocitrate Dehydrogenase - metabolism L-Lactate dehydrogenase L-Lactate Dehydrogenase - antagonists & inhibitors L-Lactate Dehydrogenase - metabolism Lactate dehydrogenase Lactic acid Lymphocytes Lymphocytes T Metabolites Mice Mutation Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism
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