Intracellular antibody targeting HBx suppresses invasion and metastasis in hepatitis B virus‐related hepatocarcinogenesis via protein phosphatase 2A‐B56γ‐mediated dephosphorylation of protein kinase B

Objectives Hepatitis B virus X (HBx) is closely associated with HBV‐related hepatocarcinogenesis via the inactivation of tumour suppressors. Protein phosphatase 2A (PP2A) regulatory subunit B56 gamma (B56γ), as a tumour suppressor, plays a critical role in regulating cellular phosphorylation signals...

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Veröffentlicht in:	Cell proliferation 2022-11, Vol.55 (11), p.e13304-n/a
Hauptverfasser:	Che, Lin, Du, Ze‐Bang, Wang, Wei‐Hua, Wu, Jia‐Shen, Han, Tun, Chen, Yuan‐Yuan, Han, Pei‐Yu, Lei, Zhao, Chen, Xiao‐Xuan, He, Yun, Xu, Ling, Lin, Xu, Lin, Zhong‐Ning, Lin, Yu‐Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antibodies Bioinformatics Carcinogenesis Carcinogens Cell cycle Cell migration Dephosphorylation Ethics Gelatinase A Gelatinase B Gene expression Genetic engineering Genetics Genomes Hepatitis Hepatitis B Hepatitis B virus Inactivation Infections Intracellular Kinases Laboratory animals Liver cancer Matrix metalloproteinase Matrix metalloproteinases Metalloproteinase Metastases Metastasis Monoclonal antibodies Original Phenotypes Phosphatase Phosphatases Phosphoprotein phosphatase Phosphorylation Plasmids Protein kinases Protein phosphatase Proteins Signal transduction Site-directed mutagenesis Suppressors Tissues Transgenic mice Tumor suppressor genes Tumors Viral antibodies Viruses Xenografts Xenotransplantation
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