A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation

Protein UFMylation, i.e., post‐translational modification with ubiquitin‐fold modifier 1 (UFM1), is essential for cellular and endoplasmic reticulum homeostasis. Despite its biological importance, we have a poor understanding of how UFM1 is conjugated onto substrates. Here, we use a rebuilding appro...

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Veröffentlicht in:	The EMBO journal 2022-11, Vol.41 (21), p.e111015-n/a
Hauptverfasser:	Peter, Joshua J, Magnussen, Helge M, DaRosa, Paul A, Millrine, David, Matthews, Stephen P, Lamoliatte, Frederic, Sundaramoorthy, Ramasubramanian, Kopito, Ron R, Kulathu, Yogesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapters Adaptor Proteins, Signal Transducing - metabolism E3 ligase EMBO31 Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - physiology enzyme substrate Enzymes Homeostasis post‐translational modification Principles Protein Binding Protein folding Protein Processing, Post-Translational Proteins Ribosomal Proteins - metabolism ribosome Ribosomes Scaffolds Substrates Translation Ubiquitin Ubiquitin-conjugating enzyme Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism ubiquitin‐like modifier
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