m6A is required for resolving progenitor identity during planarian stem cell differentiation

Regeneration and tissue homeostasis require accurate production of missing cell lineages. Cell production is driven by changes to gene expression, which is shaped by multiple layers of regulation. Here, we find that the ubiquitous mRNA base‐modification, m6A, is required for proper cell fate choice...

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Veröffentlicht in:	The EMBO journal 2022-11, Vol.41 (21), p.e109895-n/a
Hauptverfasser:	Dagan, Yael, Yesharim, Yarden, Bonneau, Ashley R, Frankovits, Tamar, Schwartz, Schraga, Reddien, Peter W, Wurtzel, Omri
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Animals Body size Cell death Cell differentiation Cell Differentiation - genetics Cell fate Chromatin - metabolism Chromatin remodeling Datasets Depletion differentiation Differentiation (biology) DNA methylation EMBO09 EMBO11 Gene expression Gene mapping Gene regulation Gene sequencing Genomes Histones Homeostasis Homeostasis - genetics Kinases m6A N6-methyladenosine Perturbation planarian Planarians - physiology Regeneration RNA modification Stem cell transplantation Stem cells Stem Cells - metabolism Transcriptomes
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