Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation

Introduction Neurofibrillary tangle (NFT) of hyperphosphorylated tau is a hallmark of Alzheimer's disease (AD) and related tauopathies. Tau lesion starts in the trans‐entorhinal cortex, from where it spreads to limbic regions, followed by neocortical areas. The regional distribution of NFTs ass...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2022-12, Vol.28 (12), p.2245-2259
Hauptverfasser:	Li, Longfei, Miao, Jin, Chu, Dandan, Jin, Nana, Tung, Yunn Chyn, Dai, Chun‐Ling, Hu, Wen, Gong, Cheng‐Xin, Iqbal, Khalid, Liu, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer's disease Animal cognition Animals Antibodies Antibodies, Monoclonal Brain - metabolism Brain research Cognitive ability Cortex (entorhinal) Dementia Hippocampus Immunotherapy Internalization Intravenous administration Laboratory animals Mice Microtubules - metabolism Microtubules - pathology Neurodegenerative diseases Original Pathology Peptides Phosphorylation propagation of tau pathology Protein seeding tau tau pathology Tau protein tau Proteins - metabolism Tauopathies - metabolism Tauopathies - pathology Transgenic animals
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