Enhancement of astrocytic gap junctions Connexin43 coupling can improve long‐term isoflurane anesthesia–mediated brain network abnormalities and cognitive impairment

Aim Astrocytes are connected by gap junctions Connexin43 (GJs‐Cx43) forming an extensive intercellular network and maintain brain homeostasis. Perioperative neurocognitive disorder (PND) occurs frequently after anesthesia/surgery and worsens patient outcome, but the neural circuit mechanisms remain...

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Veröffentlicht in:	CNS neuroscience & therapeutics 2022-12, Vol.28 (12), p.2281-2297
Hauptverfasser:	Dong, Rui, Lv, Pin, Han, Yuqiang, Jiang, Linhao, Wang, Zimo, Peng, Liangyu, Ma, Zhengliang, Xia, Tianjiao, Zhang, Bing, Gu, Xiaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Anesthesia Animal cognition Animals Astrocytes astrocytic network Brain Brain - metabolism Brain Diseases - metabolism Brain mapping Cognition Cognitive ability Cognitive Dysfunction - metabolism cognitive impairment Connexin 43 Connexin 43 - metabolism Connexin43 Coronaviruses COVID-19 Data processing Disease transmission Experiments Fear conditioning Flow cytometry Functional magnetic resonance imaging gap junction Gap junctions Gap Junctions - metabolism Hippocampus Hippocampus - metabolism Homeostasis Inflammation Isoflurane Isoflurane - metabolism Magnetic resonance imaging Male Manganese Memory MEMRI Mice Mice, Inbred C57BL Neural networks Neurodegeneration Neuroimaging Original Oxidative stress rs‐fMRI Sleep and wakefulness Software
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