Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers

The RAS family of small GTPases represents the most commonly activated oncogenes in human cancers. To better understand the prevalence of somatic RAS mutations and the compendium of genes that are coaltered in RAS-mutant tumors, we analyzed targeted next-generation sequencing data of 607,863 mutatio...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2022-11, Vol.82 (21), p.4058-4078
Hauptverfasser:	Scharpf, Robert B, Balan, Archana, Ricciuti, Biagio, Fiksel, Jacob, Cherry, Christopher, Wang, Chenguang, Lenoue-Newton, Michele L, Rizvi, Hira A, White, James R, Baras, Alexander S, Anaya, Jordan, Landon, Blair V, Majcherska-Agrawal, Marta, Ghanem, Paola, Lee, Jocelyn, Raskin, Leon, Park, Andrew S, Tu, Huakang, Hsu, Hil, Arbour, Kathryn C, Awad, Mark M, Riely, Gregory J, Lovly, Christine M, Anagnostou, Valsamo
Format:	Artikel
Sprache:	eng
Schlagworte:	Bayes Theorem Carcinoma, Non-Small-Cell Lung - pathology Genomics Humans Lung Neoplasms - pathology Mutation Proto-Oncogene Proteins p21(ras) - genetics Tumor Microenvironment
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