Elucidation of the substrate of tRNA-modifying enzymes MnmEG leads to in vitro reconstitution of an evolutionarily conserved uridine hypermodification

The evolutionarily conserved bacterial proteins MnmE and MnmG collectively install a carboxymethylaminomethyl (cmnm) group at the fifth position of wobble uridines of several tRNA species. While the reaction catalyzed by MnmEG is one of the central steps in the biosynthesis of the methylaminomethyl...

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Veröffentlicht in:	The Journal of biological chemistry 2022-11, Vol.298 (11), p.102548-102548, Article 102548
Hauptverfasser:	Bommisetti, Praneeth, Young, Anthony, Bandarian, Vahe
Format:	Artikel
Sprache:	eng
Schlagworte:	biochemistry Escherichia coli Proteins - metabolism nucleic acid enzymology One-Carbon Group Transferases - genetics One-Carbon Group Transferases - metabolism Reducing Agents RNA modifications RNA, Transfer - metabolism tRNA tRNA methyltransferase Uridine
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