Potential Mechanisms Involved in Chronic Kidney Disease of Unclear Etiology
The etiology of chronic kidney disease of unclear etiology, also known as Mesoamerican nephropathy, remains unclear. We investigated potential etiologies for Mesoamerican nephropathy in an immigrant dialysis population. Migrants with Mesoamerican nephropathy kidney failure ( =52) were identified by...
Gespeichert in:
| Veröffentlicht in: | Clinical journal of the American Society of Nephrology 2022-09, Vol.17 (9), p.1293-1304 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1304 |
|---|---|
| container_issue | 9 |
| container_start_page | 1293 |
| container_title | Clinical journal of the American Society of Nephrology |
| container_volume | 17 |
| creator | Holliday, Jr, Michael W Li, Qingtian Bustamante, Edlyn G Niu, Jingbo Huang, Luping Espina, Ilse M Dominguez, Jose R Truong, Luan Murray, Kristy O Fan, Lei Anumudu, Samaya J Shah, Maulin Fischer, Rebecca S B Vangala, Chandan Mandayam, Sreedhar Perez, Jose Pan, Jenny S Ali, Sehrish Awan, Ahmed A Sheikh-Hamad, David |
| description | The etiology of chronic kidney disease of unclear etiology, also known as Mesoamerican nephropathy, remains unclear. We investigated potential etiologies for Mesoamerican nephropathy in an immigrant dialysis population.
Migrants with Mesoamerican nephropathy kidney failure (
=52) were identified by exclusion of known causes of kidney disease and compared using a cross-sectional survey with demographically similar patients with kidney failure from other causes (
=63) and age/sex/place of origin-matched healthy participants (
=16). Survey results were extended to the bench; C57BL/6 mice (
=73) received 10-15 weekly intraperitoneal injections of paraquat (a reactive oxygen species-generating herbicide) or vehicle. Kidney function, histology, and expression of organic cation transporter-2 (proximal tubule entry for paraquat) and multidrug and toxin extrusion 1 (extrusion pathway) were examined. Kidney biopsies from Nicaraguan patients with acute Mesoamerican nephropathy were stained for the above transporters and compared with patients with tubulointerstitial nephritis and without Mesoamerican nephropathy.
Patients with Mesoamerican nephropathy and kidney failure were young agricultural workers, almost exclusively men; the majority were from Mexico and El Salvador; and they had prior exposures to agrochemicals, including paraquat (27%). After adjustment for age/sex, exposure to any agrochemical or paraquat was associated with Mesoamerican nephropathy kidney failure (odds ratio, 4.86; 95% confidence interval, 1.82 to 12.96;
=0.002 and odds ratio, 12.25; 95% confidence interval, 1.51 to 99.36;
=0.02, respectively). Adjusted for age/sex and other covariates, 1 year of agrochemical exposure was associated with Mesoamerican nephropathy kidney failure (odds ratio, 1.23; 95% confidence interval, 1.04 to 1.44;
=0.02). Compared with 16 matched healthy controls, Mesoamerican nephropathy kidney failure was significantly associated with exposure to paraquat and agrochemicals. Paraquat-treated male mice developed kidney failure and tubulointerstitial nephritis consistent with Mesoamerican nephropathy. Organic cation transporter-2 expression was higher in male kidneys versus female kidneys. Paraquat treatment increased organic cation transporter-2 expression and decreased multidrug and toxin extrusion 1 expression in male kidneys; similar results were observed in the kidneys of Nicaraguan patients with Mesoamerican nephropathy.
Exposure to agrochemicals is associated with M |
| doi_str_mv | 10.2215/CJN.16831221 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9625092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2700640246</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-bfd55b6cf0b3a10a282d938d98cbec5f076cbf879da3762ff931a417bb4b18b43</originalsourceid><addsrcrecordid>eNpVkLtPwzAQhy0EglLYmJFHBgJ-JvGChMK75TGAxGbZjk2NErvEaaX-9wQBFUx3p_v0u9MHwAFGJ4RgflrdPZzgvKR4mDbACHPOM4H46-a6Z3gH7Kb0jhBjlPBtsEO5YExgPAKTp9jb0HvVwHtrZir41CZ4G5axWdoa-gCrWReDN3Di62BX8MInq5KF0cGXYBqrOnjZ-9jEt9Ue2HKqSXb_p47By9Xlc3WTTR-vb6vzaWZoyfpMu5pznRuHNFUYKVKSWtCyFqXR1nCHitxoVxaiVrTIiXOCYsVwoTXTuNSMjsHZd-58oVtbm-H_TjVy3vlWdSsZlZf_N8HP5FtcSpETjgQZAo5-Arr4sbCpl61PxjaNCjYukiQFQjlDhOUDevyNmi6m1Fm3PoOR_PIvB__y1_-AH_59bQ3_CqefQmOB2g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2700640246</pqid></control><display><type>article</type><title>Potential Mechanisms Involved in Chronic Kidney Disease of Unclear Etiology</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Holliday, Jr, Michael W ; Li, Qingtian ; Bustamante, Edlyn G ; Niu, Jingbo ; Huang, Luping ; Espina, Ilse M ; Dominguez, Jose R ; Truong, Luan ; Murray, Kristy O ; Fan, Lei ; Anumudu, Samaya J ; Shah, Maulin ; Fischer, Rebecca S B ; Vangala, Chandan ; Mandayam, Sreedhar ; Perez, Jose ; Pan, Jenny S ; Ali, Sehrish ; Awan, Ahmed A ; Sheikh-Hamad, David</creator><creatorcontrib>Holliday, Jr, Michael W ; Li, Qingtian ; Bustamante, Edlyn G ; Niu, Jingbo ; Huang, Luping ; Espina, Ilse M ; Dominguez, Jose R ; Truong, Luan ; Murray, Kristy O ; Fan, Lei ; Anumudu, Samaya J ; Shah, Maulin ; Fischer, Rebecca S B ; Vangala, Chandan ; Mandayam, Sreedhar ; Perez, Jose ; Pan, Jenny S ; Ali, Sehrish ; Awan, Ahmed A ; Sheikh-Hamad, David</creatorcontrib><description>The etiology of chronic kidney disease of unclear etiology, also known as Mesoamerican nephropathy, remains unclear. We investigated potential etiologies for Mesoamerican nephropathy in an immigrant dialysis population.
Migrants with Mesoamerican nephropathy kidney failure (
=52) were identified by exclusion of known causes of kidney disease and compared using a cross-sectional survey with demographically similar patients with kidney failure from other causes (
=63) and age/sex/place of origin-matched healthy participants (
=16). Survey results were extended to the bench; C57BL/6 mice (
=73) received 10-15 weekly intraperitoneal injections of paraquat (a reactive oxygen species-generating herbicide) or vehicle. Kidney function, histology, and expression of organic cation transporter-2 (proximal tubule entry for paraquat) and multidrug and toxin extrusion 1 (extrusion pathway) were examined. Kidney biopsies from Nicaraguan patients with acute Mesoamerican nephropathy were stained for the above transporters and compared with patients with tubulointerstitial nephritis and without Mesoamerican nephropathy.
Patients with Mesoamerican nephropathy and kidney failure were young agricultural workers, almost exclusively men; the majority were from Mexico and El Salvador; and they had prior exposures to agrochemicals, including paraquat (27%). After adjustment for age/sex, exposure to any agrochemical or paraquat was associated with Mesoamerican nephropathy kidney failure (odds ratio, 4.86; 95% confidence interval, 1.82 to 12.96;
=0.002 and odds ratio, 12.25; 95% confidence interval, 1.51 to 99.36;
=0.02, respectively). Adjusted for age/sex and other covariates, 1 year of agrochemical exposure was associated with Mesoamerican nephropathy kidney failure (odds ratio, 1.23; 95% confidence interval, 1.04 to 1.44;
=0.02). Compared with 16 matched healthy controls, Mesoamerican nephropathy kidney failure was significantly associated with exposure to paraquat and agrochemicals. Paraquat-treated male mice developed kidney failure and tubulointerstitial nephritis consistent with Mesoamerican nephropathy. Organic cation transporter-2 expression was higher in male kidneys versus female kidneys. Paraquat treatment increased organic cation transporter-2 expression and decreased multidrug and toxin extrusion 1 expression in male kidneys; similar results were observed in the kidneys of Nicaraguan patients with Mesoamerican nephropathy.
Exposure to agrochemicals is associated with Mesoamerican nephropathy, and chronic exposure of mice to paraquat, a prototypical oxidant, induced kidney failure similar to Mesoamerican nephropathy.</description><identifier>ISSN: 1555-9041</identifier><identifier>ISSN: 1555-905X</identifier><identifier>EISSN: 1555-905X</identifier><identifier>DOI: 10.2215/CJN.16831221</identifier><identifier>PMID: 35944911</identifier><language>eng</language><publisher>United States: American Society of Nephrology</publisher><subject>Agrochemicals ; Animals ; Cations ; Chronic Kidney Diseases of Uncertain Etiology ; Cross-Sectional Studies ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Nephritis, Interstitial - pathology ; Original ; Paraquat - toxicity ; Renal Insufficiency ; Renal Insufficiency, Chronic - epidemiology</subject><ispartof>Clinical journal of the American Society of Nephrology, 2022-09, Vol.17 (9), p.1293-1304</ispartof><rights>Copyright © 2022 by the American Society of Nephrology.</rights><rights>Copyright © 2022 by the American Society of Nephrology 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-bfd55b6cf0b3a10a282d938d98cbec5f076cbf879da3762ff931a417bb4b18b43</citedby><cites>FETCH-LOGICAL-c384t-bfd55b6cf0b3a10a282d938d98cbec5f076cbf879da3762ff931a417bb4b18b43</cites><orcidid>0000-0003-4436-4191 ; 0000-0002-5048-2955</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625092/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9625092/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35944911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holliday, Jr, Michael W</creatorcontrib><creatorcontrib>Li, Qingtian</creatorcontrib><creatorcontrib>Bustamante, Edlyn G</creatorcontrib><creatorcontrib>Niu, Jingbo</creatorcontrib><creatorcontrib>Huang, Luping</creatorcontrib><creatorcontrib>Espina, Ilse M</creatorcontrib><creatorcontrib>Dominguez, Jose R</creatorcontrib><creatorcontrib>Truong, Luan</creatorcontrib><creatorcontrib>Murray, Kristy O</creatorcontrib><creatorcontrib>Fan, Lei</creatorcontrib><creatorcontrib>Anumudu, Samaya J</creatorcontrib><creatorcontrib>Shah, Maulin</creatorcontrib><creatorcontrib>Fischer, Rebecca S B</creatorcontrib><creatorcontrib>Vangala, Chandan</creatorcontrib><creatorcontrib>Mandayam, Sreedhar</creatorcontrib><creatorcontrib>Perez, Jose</creatorcontrib><creatorcontrib>Pan, Jenny S</creatorcontrib><creatorcontrib>Ali, Sehrish</creatorcontrib><creatorcontrib>Awan, Ahmed A</creatorcontrib><creatorcontrib>Sheikh-Hamad, David</creatorcontrib><title>Potential Mechanisms Involved in Chronic Kidney Disease of Unclear Etiology</title><title>Clinical journal of the American Society of Nephrology</title><addtitle>Clin J Am Soc Nephrol</addtitle><description>The etiology of chronic kidney disease of unclear etiology, also known as Mesoamerican nephropathy, remains unclear. We investigated potential etiologies for Mesoamerican nephropathy in an immigrant dialysis population.
Migrants with Mesoamerican nephropathy kidney failure (
=52) were identified by exclusion of known causes of kidney disease and compared using a cross-sectional survey with demographically similar patients with kidney failure from other causes (
=63) and age/sex/place of origin-matched healthy participants (
=16). Survey results were extended to the bench; C57BL/6 mice (
=73) received 10-15 weekly intraperitoneal injections of paraquat (a reactive oxygen species-generating herbicide) or vehicle. Kidney function, histology, and expression of organic cation transporter-2 (proximal tubule entry for paraquat) and multidrug and toxin extrusion 1 (extrusion pathway) were examined. Kidney biopsies from Nicaraguan patients with acute Mesoamerican nephropathy were stained for the above transporters and compared with patients with tubulointerstitial nephritis and without Mesoamerican nephropathy.
Patients with Mesoamerican nephropathy and kidney failure were young agricultural workers, almost exclusively men; the majority were from Mexico and El Salvador; and they had prior exposures to agrochemicals, including paraquat (27%). After adjustment for age/sex, exposure to any agrochemical or paraquat was associated with Mesoamerican nephropathy kidney failure (odds ratio, 4.86; 95% confidence interval, 1.82 to 12.96;
=0.002 and odds ratio, 12.25; 95% confidence interval, 1.51 to 99.36;
=0.02, respectively). Adjusted for age/sex and other covariates, 1 year of agrochemical exposure was associated with Mesoamerican nephropathy kidney failure (odds ratio, 1.23; 95% confidence interval, 1.04 to 1.44;
=0.02). Compared with 16 matched healthy controls, Mesoamerican nephropathy kidney failure was significantly associated with exposure to paraquat and agrochemicals. Paraquat-treated male mice developed kidney failure and tubulointerstitial nephritis consistent with Mesoamerican nephropathy. Organic cation transporter-2 expression was higher in male kidneys versus female kidneys. Paraquat treatment increased organic cation transporter-2 expression and decreased multidrug and toxin extrusion 1 expression in male kidneys; similar results were observed in the kidneys of Nicaraguan patients with Mesoamerican nephropathy.
Exposure to agrochemicals is associated with Mesoamerican nephropathy, and chronic exposure of mice to paraquat, a prototypical oxidant, induced kidney failure similar to Mesoamerican nephropathy.</description><subject>Agrochemicals</subject><subject>Animals</subject><subject>Cations</subject><subject>Chronic Kidney Diseases of Uncertain Etiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nephritis, Interstitial - pathology</subject><subject>Original</subject><subject>Paraquat - toxicity</subject><subject>Renal Insufficiency</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><issn>1555-9041</issn><issn>1555-905X</issn><issn>1555-905X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkLtPwzAQhy0EglLYmJFHBgJ-JvGChMK75TGAxGbZjk2NErvEaaX-9wQBFUx3p_v0u9MHwAFGJ4RgflrdPZzgvKR4mDbACHPOM4H46-a6Z3gH7Kb0jhBjlPBtsEO5YExgPAKTp9jb0HvVwHtrZir41CZ4G5axWdoa-gCrWReDN3Di62BX8MInq5KF0cGXYBqrOnjZ-9jEt9Ue2HKqSXb_p47By9Xlc3WTTR-vb6vzaWZoyfpMu5pznRuHNFUYKVKSWtCyFqXR1nCHitxoVxaiVrTIiXOCYsVwoTXTuNSMjsHZd-58oVtbm-H_TjVy3vlWdSsZlZf_N8HP5FtcSpETjgQZAo5-Arr4sbCpl61PxjaNCjYukiQFQjlDhOUDevyNmi6m1Fm3PoOR_PIvB__y1_-AH_59bQ3_CqefQmOB2g</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Holliday, Jr, Michael W</creator><creator>Li, Qingtian</creator><creator>Bustamante, Edlyn G</creator><creator>Niu, Jingbo</creator><creator>Huang, Luping</creator><creator>Espina, Ilse M</creator><creator>Dominguez, Jose R</creator><creator>Truong, Luan</creator><creator>Murray, Kristy O</creator><creator>Fan, Lei</creator><creator>Anumudu, Samaya J</creator><creator>Shah, Maulin</creator><creator>Fischer, Rebecca S B</creator><creator>Vangala, Chandan</creator><creator>Mandayam, Sreedhar</creator><creator>Perez, Jose</creator><creator>Pan, Jenny S</creator><creator>Ali, Sehrish</creator><creator>Awan, Ahmed A</creator><creator>Sheikh-Hamad, David</creator><general>American Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4436-4191</orcidid><orcidid>https://orcid.org/0000-0002-5048-2955</orcidid></search><sort><creationdate>202209</creationdate><title>Potential Mechanisms Involved in Chronic Kidney Disease of Unclear Etiology</title><author>Holliday, Jr, Michael W ; Li, Qingtian ; Bustamante, Edlyn G ; Niu, Jingbo ; Huang, Luping ; Espina, Ilse M ; Dominguez, Jose R ; Truong, Luan ; Murray, Kristy O ; Fan, Lei ; Anumudu, Samaya J ; Shah, Maulin ; Fischer, Rebecca S B ; Vangala, Chandan ; Mandayam, Sreedhar ; Perez, Jose ; Pan, Jenny S ; Ali, Sehrish ; Awan, Ahmed A ; Sheikh-Hamad, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-bfd55b6cf0b3a10a282d938d98cbec5f076cbf879da3762ff931a417bb4b18b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Agrochemicals</topic><topic>Animals</topic><topic>Cations</topic><topic>Chronic Kidney Diseases of Uncertain Etiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nephritis, Interstitial - pathology</topic><topic>Original</topic><topic>Paraquat - toxicity</topic><topic>Renal Insufficiency</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holliday, Jr, Michael W</creatorcontrib><creatorcontrib>Li, Qingtian</creatorcontrib><creatorcontrib>Bustamante, Edlyn G</creatorcontrib><creatorcontrib>Niu, Jingbo</creatorcontrib><creatorcontrib>Huang, Luping</creatorcontrib><creatorcontrib>Espina, Ilse M</creatorcontrib><creatorcontrib>Dominguez, Jose R</creatorcontrib><creatorcontrib>Truong, Luan</creatorcontrib><creatorcontrib>Murray, Kristy O</creatorcontrib><creatorcontrib>Fan, Lei</creatorcontrib><creatorcontrib>Anumudu, Samaya J</creatorcontrib><creatorcontrib>Shah, Maulin</creatorcontrib><creatorcontrib>Fischer, Rebecca S B</creatorcontrib><creatorcontrib>Vangala, Chandan</creatorcontrib><creatorcontrib>Mandayam, Sreedhar</creatorcontrib><creatorcontrib>Perez, Jose</creatorcontrib><creatorcontrib>Pan, Jenny S</creatorcontrib><creatorcontrib>Ali, Sehrish</creatorcontrib><creatorcontrib>Awan, Ahmed A</creatorcontrib><creatorcontrib>Sheikh-Hamad, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical journal of the American Society of Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holliday, Jr, Michael W</au><au>Li, Qingtian</au><au>Bustamante, Edlyn G</au><au>Niu, Jingbo</au><au>Huang, Luping</au><au>Espina, Ilse M</au><au>Dominguez, Jose R</au><au>Truong, Luan</au><au>Murray, Kristy O</au><au>Fan, Lei</au><au>Anumudu, Samaya J</au><au>Shah, Maulin</au><au>Fischer, Rebecca S B</au><au>Vangala, Chandan</au><au>Mandayam, Sreedhar</au><au>Perez, Jose</au><au>Pan, Jenny S</au><au>Ali, Sehrish</au><au>Awan, Ahmed A</au><au>Sheikh-Hamad, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential Mechanisms Involved in Chronic Kidney Disease of Unclear Etiology</atitle><jtitle>Clinical journal of the American Society of Nephrology</jtitle><addtitle>Clin J Am Soc Nephrol</addtitle><date>2022-09</date><risdate>2022</risdate><volume>17</volume><issue>9</issue><spage>1293</spage><epage>1304</epage><pages>1293-1304</pages><issn>1555-9041</issn><issn>1555-905X</issn><eissn>1555-905X</eissn><abstract>The etiology of chronic kidney disease of unclear etiology, also known as Mesoamerican nephropathy, remains unclear. We investigated potential etiologies for Mesoamerican nephropathy in an immigrant dialysis population.
Migrants with Mesoamerican nephropathy kidney failure (
=52) were identified by exclusion of known causes of kidney disease and compared using a cross-sectional survey with demographically similar patients with kidney failure from other causes (
=63) and age/sex/place of origin-matched healthy participants (
=16). Survey results were extended to the bench; C57BL/6 mice (
=73) received 10-15 weekly intraperitoneal injections of paraquat (a reactive oxygen species-generating herbicide) or vehicle. Kidney function, histology, and expression of organic cation transporter-2 (proximal tubule entry for paraquat) and multidrug and toxin extrusion 1 (extrusion pathway) were examined. Kidney biopsies from Nicaraguan patients with acute Mesoamerican nephropathy were stained for the above transporters and compared with patients with tubulointerstitial nephritis and without Mesoamerican nephropathy.
Patients with Mesoamerican nephropathy and kidney failure were young agricultural workers, almost exclusively men; the majority were from Mexico and El Salvador; and they had prior exposures to agrochemicals, including paraquat (27%). After adjustment for age/sex, exposure to any agrochemical or paraquat was associated with Mesoamerican nephropathy kidney failure (odds ratio, 4.86; 95% confidence interval, 1.82 to 12.96;
=0.002 and odds ratio, 12.25; 95% confidence interval, 1.51 to 99.36;
=0.02, respectively). Adjusted for age/sex and other covariates, 1 year of agrochemical exposure was associated with Mesoamerican nephropathy kidney failure (odds ratio, 1.23; 95% confidence interval, 1.04 to 1.44;
=0.02). Compared with 16 matched healthy controls, Mesoamerican nephropathy kidney failure was significantly associated with exposure to paraquat and agrochemicals. Paraquat-treated male mice developed kidney failure and tubulointerstitial nephritis consistent with Mesoamerican nephropathy. Organic cation transporter-2 expression was higher in male kidneys versus female kidneys. Paraquat treatment increased organic cation transporter-2 expression and decreased multidrug and toxin extrusion 1 expression in male kidneys; similar results were observed in the kidneys of Nicaraguan patients with Mesoamerican nephropathy.
Exposure to agrochemicals is associated with Mesoamerican nephropathy, and chronic exposure of mice to paraquat, a prototypical oxidant, induced kidney failure similar to Mesoamerican nephropathy.</abstract><cop>United States</cop><pub>American Society of Nephrology</pub><pmid>35944911</pmid><doi>10.2215/CJN.16831221</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4436-4191</orcidid><orcidid>https://orcid.org/0000-0002-5048-2955</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1555-9041 |
| ispartof | Clinical journal of the American Society of Nephrology, 2022-09, Vol.17 (9), p.1293-1304 |
| issn | 1555-9041 1555-905X 1555-905X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9625092 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Agrochemicals Animals Cations Chronic Kidney Diseases of Uncertain Etiology Cross-Sectional Studies Female Male Mice Mice, Inbred C57BL Nephritis, Interstitial - pathology Original Paraquat - toxicity Renal Insufficiency Renal Insufficiency, Chronic - epidemiology |
| title | Potential Mechanisms Involved in Chronic Kidney Disease of Unclear Etiology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T06%3A19%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Potential%20Mechanisms%20Involved%20in%20Chronic%20Kidney%20Disease%20of%20Unclear%20Etiology&rft.jtitle=Clinical%20journal%20of%20the%20American%20Society%20of%20Nephrology&rft.au=Holliday,%20Jr,%20Michael%20W&rft.date=2022-09&rft.volume=17&rft.issue=9&rft.spage=1293&rft.epage=1304&rft.pages=1293-1304&rft.issn=1555-9041&rft.eissn=1555-905X&rft_id=info:doi/10.2215/CJN.16831221&rft_dat=%3Cproquest_pubme%3E2700640246%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2700640246&rft_id=info:pmid/35944911&rfr_iscdi=true |