Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing sporadic Alzheimer’s disease. How the interaction of APOE4 microglia with neurons differs from microglia expressing the disease-neutral APOE3 allele remains unknown. Here, we employ CRISPR-edited induced pluripotent s...

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Veröffentlicht in:	Cell stem cell 2022-08, Vol.29 (8), p.1197-1212.e8
Hauptverfasser:	Victor, Matheus B., Leary, Noelle, Luna, Xochitl, Meharena, Hiruy S., Scannail, Aine Ni, Bozzelli, P. Lorenzo, Samaan, George, Murdock, Mitchell H., von Maydell, Djuna, Effenberger, Audrey H., Cerit, Oyku, Wen, Hsin-Lan, Liu, Liwang, Welch, Gwyneth, Bonner, Maeve, Tsai, Li-Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease Alzheimer’s risk variant APOE Apolipoprotein E3 - genetics Apolipoprotein E4 - genetics calcium dynamics forebrain spheroids GIRKs Humans lipid droplet Microglia network-activity Neurons stem cells
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