Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis

Glioblastoma (GBM), a malignant brain tumor, is a world-wide health problem because of its poor prognosis and high rates of recurrence and mortality. Apolipoprotein C1 (APOC1) is the smallest of apolipoproteins, implicated in many diseases. Recent studies have shown that APOC1 promotes tumorigenesis...

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Veröffentlicht in:	Acta pharmacologica Sinica 2022-11, Vol.43 (11), p.2977-2992
Hauptverfasser:	Zheng, Xiang-jin, Chen, Wen-lin, Yi, Jie, Li, Wan, Liu, Jin-yi, Fu, Wei-qi, Ren, Li-wen, Li, Sha, Ge, Bin-bin, Yang, Yi-hui, Zhang, Yi-zhi, Yang, Hong, Du, Guan-hua, Wang, Yu, Wang, Jin-hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein C-I - metabolism Apolipoproteins Biomedical and Life Sciences Biomedicine Brain cancer Brain tumors Carcinogenesis - metabolism Cell Line, Tumor Cell migration Cell proliferation Cell Transformation, Neoplastic Cystathionine b-synthase Cystathionine beta-Synthase - metabolism Ferroptosis Gene Expression Regulation, Neoplastic Glioblastoma Glioblastoma - metabolism Glutathione peroxidase Humans Immunology Internal Medicine Kelch-Like ECH-Associated Protein 1 - metabolism Medical Microbiology Mice Mice, Nude NF-E2-Related Factor 2 - metabolism Nuclear transport Pharmacology/Toxicology Therapeutic targets Tumorigenesis Vaccine Ventricle Ventricles (cerebral) Xenografts
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