S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission

Graft-versus-host disease (GVHD) significantly contributes to patient morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HSCT). Sphingosine-1-phosphate (S1P) signaling is involved in the biogenetic processes of different immune cells. In the current study, we demonstra...

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Veröffentlicht in:	Cellular & molecular immunology 2022-11, Vol.19 (11), p.1235-1250
Hauptverfasser:	Tian, Linlu, Wu, Yongxia, Choi, Hee-Jin, Sui, Xiaohui, Li, Xinlei, Sofi, M. Hanief, Kassir, Mohamed Faisal, Chen, Xiao, Mehrotra, Shikhar, Ogretmen, Besim, Yu, Xue-Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/1854/2812 AKT protein Antibodies Biomedical and Life Sciences Biomedicine Blood cancer CD4 antigen CD4-Positive T-Lymphocytes CD8 antigen CD8-Positive T-Lymphocytes Cell differentiation Cytotoxicity Graft versus host disease Graft vs Host Disease Graft-versus-host reaction Helper cells Hematopoietic Stem Cell Transplantation Humans Immunology Kinases Leukemia Lymphocytes Lymphocytes T Medical Microbiology Microbiology Mitochondria Mitochondrial Dynamics Morbidity Signal transduction Sphingosine 1-phosphate Sphingosine kinase Sphingosine-1-Phosphate Receptors Stem cell transplantation Therapeutic targets TOR protein Vaccine Xenografts
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