Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode
Background Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MS ped ) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD ped ) in children > 6 years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of o...
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| Veröffentlicht in: | Journal of neurology 2022-12, Vol.269 (12), p.6366-6376 |
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| creator | Pakeerathan, T. Havla, J. Schwake, C. Salmen, A. Bigi, S. Abegg, M. Brügger, D. Ferrazzini, T. Runge, A.-K. Breu, M. Kornek, B. Bsteh, G. Felipe-Rucián, A. Ringelstein, M. Aktas, O. Karenfort, M. Wendel, E. Kleiter, I. Hellwig, K. Kümpfel, T. Thiels, C. Lücke, T. Gold, R. Rostasy, K. Ayzenberg, I. |
| description | Background
Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MS
ped
) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD
ped
) in children > 6 years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of optical coherence tomography (OCT) in differentiating between both diseases after the first ON episode.
Methods
Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls.
Results
Thirteen MOGAD
ped
(10.7 ± 4.2 years, F:M 8:5, 21 ON eyes) and 21 MS
ped
(14.3 ± 2.4 years, F:M 19:2, 24 ON eyes) patients were recruited. We observed a significantly more profound atrophy of both peripapillary and macular retinal nerve fiber layer in MOGAD
ped
compared to MS
ped
(pRNFL global: 68.2 ± 16.9 vs. 89.4 ± 12.3 µm,
p
|
| doi_str_mv | 10.1007/s00415-022-11256-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9618526</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2730178988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-6284e83679e7798182c6dcf6830a34040093a22f090f635504e676702164f3dd3</originalsourceid><addsrcrecordid>eNp9kTtvFDEUhS0EIkvgD1AgSzQ0A34_GqRogYCUKAVQW87MnV1Hs_ZgexJtyy_HYUN4FFSWfb577r0-CD2n5DUlRL8phAgqO8JYRymTqts_QCsqeLsKaR-iFeGCdJJLcYSelHJFCDFNeIyOuDTKWitX6Pt667PvK-RQauhxhhqin7CvOc3bPZ59bVrEfprSTcFDGEfIEGvwNaSIL6HeAEQ8w9BecjM4vzg9eYd9HPD5Z-zHVow9LiFuJsBpvm0RYcmhhoJhDiUN8BQ9Gv1U4NndeYy-fnj_Zf2xO7s4_bQ-Oet6oUXtFDMCDFfagtbWUMN6NfSjMpz4tqcgxHLP2EgsGRWXkghQWmnCqBIjHwZ-jN4efOflcgdD37bIfnJzDjuf9y754P5WYti6Tbp2VlEjmWoGr-4Mcvq2QKluF0oP0-QjpKU4pizXhmphG_ryH_QqLbl9bKM0J1Qba0yj2IHqcyolw3g_DCXuNmJ3iNi1iN3PiN2-Fb34c437kl-ZNoAfgNKkuIH8u_d_bH8AaKSziA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2730178988</pqid></control><display><type>article</type><title>Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Pakeerathan, T. ; Havla, J. ; Schwake, C. ; Salmen, A. ; Bigi, S. ; Abegg, M. ; Brügger, D. ; Ferrazzini, T. ; Runge, A.-K. ; Breu, M. ; Kornek, B. ; Bsteh, G. ; Felipe-Rucián, A. ; Ringelstein, M. ; Aktas, O. ; Karenfort, M. ; Wendel, E. ; Kleiter, I. ; Hellwig, K. ; Kümpfel, T. ; Thiels, C. ; Lücke, T. ; Gold, R. ; Rostasy, K. ; Ayzenberg, I.</creator><creatorcontrib>Pakeerathan, T. ; Havla, J. ; Schwake, C. ; Salmen, A. ; Bigi, S. ; Abegg, M. ; Brügger, D. ; Ferrazzini, T. ; Runge, A.-K. ; Breu, M. ; Kornek, B. ; Bsteh, G. ; Felipe-Rucián, A. ; Ringelstein, M. ; Aktas, O. ; Karenfort, M. ; Wendel, E. ; Kleiter, I. ; Hellwig, K. ; Kümpfel, T. ; Thiels, C. ; Lücke, T. ; Gold, R. ; Rostasy, K. ; Ayzenberg, I.</creatorcontrib><description>Background
Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MS
ped
) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD
ped
) in children > 6 years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of optical coherence tomography (OCT) in differentiating between both diseases after the first ON episode.
Methods
Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls.
Results
Thirteen MOGAD
ped
(10.7 ± 4.2 years, F:M 8:5, 21 ON eyes) and 21 MS
ped
(14.3 ± 2.4 years, F:M 19:2, 24 ON eyes) patients were recruited. We observed a significantly more profound atrophy of both peripapillary and macular retinal nerve fiber layer in MOGAD
ped
compared to MS
ped
(pRNFL global: 68.2 ± 16.9 vs. 89.4 ± 12.3 µm,
p
< 0.001; mRNFL: 0.12 ± 0.01 vs. 0.14 ± 0.01 mm
3
,
p
< 0.001). Neither other macular layers nor P100 latency differed. MOGAD
ped
developed global atrophy affecting all peripapillary segments, while MS
ped
displayed predominantly temporal thinning. Nasal pRNFL allowed differentiation between both diseases with the highest diagnostic accuracy (AUC = 0.902, cutoff < 62.5 µm, 90.5% sensitivity and 70.8% specificity for MOGAD
ped
). OCT was also substantially more sensitive compared to VEP in identification of ON eyes in MOGAD (pathological findings in 90% vs. 14%,
p
= 0.016).
Conclusion
First MOGAD-ON results in a more severe global peripapillary atrophy compared to predominantly temporal thinning in MS-ON. Nasal pRNFL allows differentiation between both diseases with the highest accuracy, supporting the additional diagnostic value of OCT in children with ON.</description><identifier>ISSN: 0340-5354</identifier><identifier>ISSN: 1432-1459</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-022-11256-y</identifier><identifier>PMID: 35869995</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Accuracy ; Acuity ; Atrophy ; Atrophy - pathology ; Eye ; Humans ; Latency ; Medicine ; Medicine & Public Health ; Multiple sclerosis ; Multiple Sclerosis - complications ; Myelin ; Neuritis ; Neurology ; Neuroradiology ; Neurosciences ; Oligodendrocyte-myelin glycoprotein ; Optic neuritis ; Optic Neuritis - diagnosis ; Original Communication ; Patients ; Pediatrics ; Retina ; Retina - diagnostic imaging ; Retina - pathology ; Retinal degeneration ; Retinal Degeneration - pathology ; Retrospective Studies ; Thinning ; Tomography, Optical Coherence - methods ; Vision Disorders ; Visual evoked potentials</subject><ispartof>Journal of neurology, 2022-12, Vol.269 (12), p.6366-6376</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-6284e83679e7798182c6dcf6830a34040093a22f090f635504e676702164f3dd3</citedby><cites>FETCH-LOGICAL-c474t-6284e83679e7798182c6dcf6830a34040093a22f090f635504e676702164f3dd3</cites><orcidid>0000-0002-6009-792X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-022-11256-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-022-11256-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35869995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pakeerathan, T.</creatorcontrib><creatorcontrib>Havla, J.</creatorcontrib><creatorcontrib>Schwake, C.</creatorcontrib><creatorcontrib>Salmen, A.</creatorcontrib><creatorcontrib>Bigi, S.</creatorcontrib><creatorcontrib>Abegg, M.</creatorcontrib><creatorcontrib>Brügger, D.</creatorcontrib><creatorcontrib>Ferrazzini, T.</creatorcontrib><creatorcontrib>Runge, A.-K.</creatorcontrib><creatorcontrib>Breu, M.</creatorcontrib><creatorcontrib>Kornek, B.</creatorcontrib><creatorcontrib>Bsteh, G.</creatorcontrib><creatorcontrib>Felipe-Rucián, A.</creatorcontrib><creatorcontrib>Ringelstein, M.</creatorcontrib><creatorcontrib>Aktas, O.</creatorcontrib><creatorcontrib>Karenfort, M.</creatorcontrib><creatorcontrib>Wendel, E.</creatorcontrib><creatorcontrib>Kleiter, I.</creatorcontrib><creatorcontrib>Hellwig, K.</creatorcontrib><creatorcontrib>Kümpfel, T.</creatorcontrib><creatorcontrib>Thiels, C.</creatorcontrib><creatorcontrib>Lücke, T.</creatorcontrib><creatorcontrib>Gold, R.</creatorcontrib><creatorcontrib>Rostasy, K.</creatorcontrib><creatorcontrib>Ayzenberg, I.</creatorcontrib><title>Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background
Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MS
ped
) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD
ped
) in children > 6 years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of optical coherence tomography (OCT) in differentiating between both diseases after the first ON episode.
Methods
Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls.
Results
Thirteen MOGAD
ped
(10.7 ± 4.2 years, F:M 8:5, 21 ON eyes) and 21 MS
ped
(14.3 ± 2.4 years, F:M 19:2, 24 ON eyes) patients were recruited. We observed a significantly more profound atrophy of both peripapillary and macular retinal nerve fiber layer in MOGAD
ped
compared to MS
ped
(pRNFL global: 68.2 ± 16.9 vs. 89.4 ± 12.3 µm,
p
< 0.001; mRNFL: 0.12 ± 0.01 vs. 0.14 ± 0.01 mm
3
,
p
< 0.001). Neither other macular layers nor P100 latency differed. MOGAD
ped
developed global atrophy affecting all peripapillary segments, while MS
ped
displayed predominantly temporal thinning. Nasal pRNFL allowed differentiation between both diseases with the highest diagnostic accuracy (AUC = 0.902, cutoff < 62.5 µm, 90.5% sensitivity and 70.8% specificity for MOGAD
ped
). OCT was also substantially more sensitive compared to VEP in identification of ON eyes in MOGAD (pathological findings in 90% vs. 14%,
p
= 0.016).
Conclusion
First MOGAD-ON results in a more severe global peripapillary atrophy compared to predominantly temporal thinning in MS-ON. Nasal pRNFL allows differentiation between both diseases with the highest accuracy, supporting the additional diagnostic value of OCT in children with ON.</description><subject>Accuracy</subject><subject>Acuity</subject><subject>Atrophy</subject><subject>Atrophy - pathology</subject><subject>Eye</subject><subject>Humans</subject><subject>Latency</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - complications</subject><subject>Myelin</subject><subject>Neuritis</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Oligodendrocyte-myelin glycoprotein</subject><subject>Optic neuritis</subject><subject>Optic Neuritis - diagnosis</subject><subject>Original Communication</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Retina</subject><subject>Retina - diagnostic imaging</subject><subject>Retina - pathology</subject><subject>Retinal degeneration</subject><subject>Retinal Degeneration - pathology</subject><subject>Retrospective Studies</subject><subject>Thinning</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Vision Disorders</subject><subject>Visual evoked potentials</subject><issn>0340-5354</issn><issn>1432-1459</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kTtvFDEUhS0EIkvgD1AgSzQ0A34_GqRogYCUKAVQW87MnV1Hs_ZgexJtyy_HYUN4FFSWfb577r0-CD2n5DUlRL8phAgqO8JYRymTqts_QCsqeLsKaR-iFeGCdJJLcYSelHJFCDFNeIyOuDTKWitX6Pt667PvK-RQauhxhhqin7CvOc3bPZ59bVrEfprSTcFDGEfIEGvwNaSIL6HeAEQ8w9BecjM4vzg9eYd9HPD5Z-zHVow9LiFuJsBpvm0RYcmhhoJhDiUN8BQ9Gv1U4NndeYy-fnj_Zf2xO7s4_bQ-Oet6oUXtFDMCDFfagtbWUMN6NfSjMpz4tqcgxHLP2EgsGRWXkghQWmnCqBIjHwZ-jN4efOflcgdD37bIfnJzDjuf9y754P5WYti6Tbp2VlEjmWoGr-4Mcvq2QKluF0oP0-QjpKU4pizXhmphG_ryH_QqLbl9bKM0J1Qba0yj2IHqcyolw3g_DCXuNmJ3iNi1iN3PiN2-Fb34c437kl-ZNoAfgNKkuIH8u_d_bH8AaKSziA</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Pakeerathan, T.</creator><creator>Havla, J.</creator><creator>Schwake, C.</creator><creator>Salmen, A.</creator><creator>Bigi, S.</creator><creator>Abegg, M.</creator><creator>Brügger, D.</creator><creator>Ferrazzini, T.</creator><creator>Runge, A.-K.</creator><creator>Breu, M.</creator><creator>Kornek, B.</creator><creator>Bsteh, G.</creator><creator>Felipe-Rucián, A.</creator><creator>Ringelstein, M.</creator><creator>Aktas, O.</creator><creator>Karenfort, M.</creator><creator>Wendel, E.</creator><creator>Kleiter, I.</creator><creator>Hellwig, K.</creator><creator>Kümpfel, T.</creator><creator>Thiels, C.</creator><creator>Lücke, T.</creator><creator>Gold, R.</creator><creator>Rostasy, K.</creator><creator>Ayzenberg, I.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6009-792X</orcidid></search><sort><creationdate>20221201</creationdate><title>Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode</title><author>Pakeerathan, T. ; Havla, J. ; Schwake, C. ; Salmen, A. ; Bigi, S. ; Abegg, M. ; Brügger, D. ; Ferrazzini, T. ; Runge, A.-K. ; Breu, M. ; Kornek, B. ; Bsteh, G. ; Felipe-Rucián, A. ; Ringelstein, M. ; Aktas, O. ; Karenfort, M. ; Wendel, E. ; Kleiter, I. ; Hellwig, K. ; Kümpfel, T. ; Thiels, C. ; Lücke, T. ; Gold, R. ; Rostasy, K. ; Ayzenberg, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-6284e83679e7798182c6dcf6830a34040093a22f090f635504e676702164f3dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Accuracy</topic><topic>Acuity</topic><topic>Atrophy</topic><topic>Atrophy - pathology</topic><topic>Eye</topic><topic>Humans</topic><topic>Latency</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - complications</topic><topic>Myelin</topic><topic>Neuritis</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Oligodendrocyte-myelin glycoprotein</topic><topic>Optic neuritis</topic><topic>Optic Neuritis - diagnosis</topic><topic>Original Communication</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Retina</topic><topic>Retina - diagnostic imaging</topic><topic>Retina - pathology</topic><topic>Retinal degeneration</topic><topic>Retinal Degeneration - pathology</topic><topic>Retrospective Studies</topic><topic>Thinning</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Vision Disorders</topic><topic>Visual evoked potentials</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pakeerathan, T.</creatorcontrib><creatorcontrib>Havla, J.</creatorcontrib><creatorcontrib>Schwake, C.</creatorcontrib><creatorcontrib>Salmen, A.</creatorcontrib><creatorcontrib>Bigi, S.</creatorcontrib><creatorcontrib>Abegg, M.</creatorcontrib><creatorcontrib>Brügger, D.</creatorcontrib><creatorcontrib>Ferrazzini, T.</creatorcontrib><creatorcontrib>Runge, A.-K.</creatorcontrib><creatorcontrib>Breu, M.</creatorcontrib><creatorcontrib>Kornek, B.</creatorcontrib><creatorcontrib>Bsteh, G.</creatorcontrib><creatorcontrib>Felipe-Rucián, A.</creatorcontrib><creatorcontrib>Ringelstein, M.</creatorcontrib><creatorcontrib>Aktas, O.</creatorcontrib><creatorcontrib>Karenfort, M.</creatorcontrib><creatorcontrib>Wendel, E.</creatorcontrib><creatorcontrib>Kleiter, I.</creatorcontrib><creatorcontrib>Hellwig, K.</creatorcontrib><creatorcontrib>Kümpfel, T.</creatorcontrib><creatorcontrib>Thiels, C.</creatorcontrib><creatorcontrib>Lücke, T.</creatorcontrib><creatorcontrib>Gold, R.</creatorcontrib><creatorcontrib>Rostasy, K.</creatorcontrib><creatorcontrib>Ayzenberg, I.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pakeerathan, T.</au><au>Havla, J.</au><au>Schwake, C.</au><au>Salmen, A.</au><au>Bigi, S.</au><au>Abegg, M.</au><au>Brügger, D.</au><au>Ferrazzini, T.</au><au>Runge, A.-K.</au><au>Breu, M.</au><au>Kornek, B.</au><au>Bsteh, G.</au><au>Felipe-Rucián, A.</au><au>Ringelstein, M.</au><au>Aktas, O.</au><au>Karenfort, M.</au><au>Wendel, E.</au><au>Kleiter, I.</au><au>Hellwig, K.</au><au>Kümpfel, T.</au><au>Thiels, C.</au><au>Lücke, T.</au><au>Gold, R.</au><au>Rostasy, K.</au><au>Ayzenberg, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>269</volume><issue>12</issue><spage>6366</spage><epage>6376</epage><pages>6366-6376</pages><issn>0340-5354</issn><issn>1432-1459</issn><eissn>1432-1459</eissn><abstract>Background
Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MS
ped
) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD
ped
) in children > 6 years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of optical coherence tomography (OCT) in differentiating between both diseases after the first ON episode.
Methods
Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls.
Results
Thirteen MOGAD
ped
(10.7 ± 4.2 years, F:M 8:5, 21 ON eyes) and 21 MS
ped
(14.3 ± 2.4 years, F:M 19:2, 24 ON eyes) patients were recruited. We observed a significantly more profound atrophy of both peripapillary and macular retinal nerve fiber layer in MOGAD
ped
compared to MS
ped
(pRNFL global: 68.2 ± 16.9 vs. 89.4 ± 12.3 µm,
p
< 0.001; mRNFL: 0.12 ± 0.01 vs. 0.14 ± 0.01 mm
3
,
p
< 0.001). Neither other macular layers nor P100 latency differed. MOGAD
ped
developed global atrophy affecting all peripapillary segments, while MS
ped
displayed predominantly temporal thinning. Nasal pRNFL allowed differentiation between both diseases with the highest diagnostic accuracy (AUC = 0.902, cutoff < 62.5 µm, 90.5% sensitivity and 70.8% specificity for MOGAD
ped
). OCT was also substantially more sensitive compared to VEP in identification of ON eyes in MOGAD (pathological findings in 90% vs. 14%,
p
= 0.016).
Conclusion
First MOGAD-ON results in a more severe global peripapillary atrophy compared to predominantly temporal thinning in MS-ON. Nasal pRNFL allows differentiation between both diseases with the highest accuracy, supporting the additional diagnostic value of OCT in children with ON.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35869995</pmid><doi>10.1007/s00415-022-11256-y</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6009-792X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-5354 |
| ispartof | Journal of neurology, 2022-12, Vol.269 (12), p.6366-6376 |
| issn | 0340-5354 1432-1459 1432-1459 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9618526 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Accuracy Acuity Atrophy Atrophy - pathology Eye Humans Latency Medicine Medicine & Public Health Multiple sclerosis Multiple Sclerosis - complications Myelin Neuritis Neurology Neuroradiology Neurosciences Oligodendrocyte-myelin glycoprotein Optic neuritis Optic Neuritis - diagnosis Original Communication Patients Pediatrics Retina Retina - diagnostic imaging Retina - pathology Retinal degeneration Retinal Degeneration - pathology Retrospective Studies Thinning Tomography, Optical Coherence - methods Vision Disorders Visual evoked potentials |
| title | Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T17%3A12%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characteristic%20retinal%20atrophy%20pattern%20allows%20differentiation%20between%20pediatric%20MOGAD%20and%20MS%20after%20a%20single%20optic%20neuritis%20episode&rft.jtitle=Journal%20of%20neurology&rft.au=Pakeerathan,%20T.&rft.date=2022-12-01&rft.volume=269&rft.issue=12&rft.spage=6366&rft.epage=6376&rft.pages=6366-6376&rft.issn=0340-5354&rft.eissn=1432-1459&rft_id=info:doi/10.1007/s00415-022-11256-y&rft_dat=%3Cproquest_pubme%3E2730178988%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2730178988&rft_id=info:pmid/35869995&rfr_iscdi=true |