Sufu- and Spop-mediated regulation of Gli2 is essential for the control of mammalian cochlear hair cell differentiation

Development of mammalian auditory epithelium, the organ of Corti, requires precise control of both cell cycle withdrawal and differentiation. Sensory progenitors (prosensory cells) in the cochlear apex exit the cell cycle first but differentiate last. Sonic hedgehog (Shh) signaling is required for t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-10, Vol.119 (43), p.1-10
Hauptverfasser:	Qin, Tianli, Ho, Chin Chung, Wang, Boshi, Hui, Chi-Chung, Sham, Mai Har
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apexes Biodegradation Biological Sciences Cell cycle Cell differentiation Cell Differentiation - genetics Cells (biology) Cochlea Cochlea - metabolism Defects Differentiation (biology) Epithelium Gene expression Gene Expression Regulation, Developmental Gli2 protein Hair Hair Cells, Auditory - metabolism Hedgehog protein Hedgehog Proteins - metabolism Mammals Mammals - genetics Math1 protein Organ of Corti Progenitor cells Proteins RNA, Messenger - metabolism Signaling Stem cells Zinc Finger Protein Gli2 - genetics Zinc Finger Protein Gli2 - metabolism
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