CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain

Environmental factors and life experiences impinge on brain circuits triggering adaptive changes. Epigenetic regulators contribute to this neuroadaptation by enhancing or suppressing specific gene programs. The paralogous transcriptional coactivators and lysine acetyltransferases CREB binding protei...

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Veröffentlicht in:	The Journal of neuroscience 2022-10, Vol.42 (42), p.7984-8001
Hauptverfasser:	Lipinski, Michal, Niñerola, Sergio, Fuentes-Ramos, Miguel, Valor, Luis M, Del Blanco, Beatriz, López-Atalaya, Jose P, Barco, Angel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Brain Chromatin Chromatin - metabolism Circuits Cognitive ability CREB-Binding Protein - genetics CREB-Binding Protein - metabolism Cyclic AMP response element-binding protein Enrichment Environmental conditions Environmental factors Epigenesis, Genetic Epigenetics Female Forebrain Hippocampus Hippocampus - metabolism Histone Acetyltransferases - metabolism Histones Histones - metabolism Intellectual disabilities Kindling Lysine Male Mice Molecular modelling Nervous system Neural plasticity Neurons p300-CBP Transcription Factors - genetics p300-CBP Transcription Factors - metabolism Proteins Transcription Transcription Factors - metabolism
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