Cilostazol Alleviates NLRP3 Inflammasome–Induced Allodynia/Hyperalgesia in Murine Cerebral Cortex Following Transient Ischemia: Focus on TRPA1/Glutamate and Akt/Dopamine/BDNF/Nrf2 Trajectories

Global cerebral ischemia/reperfusion (I/R) provokes inflammation that augments neuropathic pain. Cilostazol (CLZ) has pleiotropic effects including neuroprotection in several ravaging central disorders; nonetheless, its potential role in transient central ischemic-induced allodynia and hyperalgesia...

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Veröffentlicht in:	Molecular neurobiology 2022-12, Vol.59 (12), p.7194-7211
Hauptverfasser:	Zaki, Omnia S., Nassar, Noha N., Abdallah, Dalaal M., Safar, Marwa M., Mohammed, Reham A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Ankyrins Apoptosis Biomedical and Life Sciences Biomedicine Brain Ischemia - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Carrier Proteins - metabolism Caspase-1 Cell Biology Cerebral blood flow Cerebral cortex Cerebral Cortex - pathology Cilostazol Cortex (cingulate) Cyclic AMP response element-binding protein Deactivation Dopamine Excitotoxicity Filaments Forkhead protein FOXO3 protein Glial fibrillary acidic protein Glutamic Acid Glutathione Hyperalgesia Hyperalgesia - pathology Inflammasomes - metabolism Inflammation Ischemia Latency Mice Neurobiology Neurology Neuropathy Neuroprotection Neurosciences Neurotransmission NF-E2-Related Factor 2 - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pain perception Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Reperfusion
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