Transcranial Direct-Current Stimulation Regulates MCT1-PPA-PTEN-LONP1 Signaling to Confer Neuroprotection After Rat Cerebral Ischemia–Reperfusion Injury

Propionic acid (PPA) is a critical metabolite involved in microbial fermentation, which functions to reduce fat production, inhibit inflammation, and reduce serum cholesterol levels. The role of PPA in the context of cerebral ischemia–reperfusion (I/R) injury has yet to be clarified. Increasing ev...

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Veröffentlicht in:	Molecular neurobiology 2022-12, Vol.59 (12), p.7423-7438
Hauptverfasser:	Kong, Xiangyi, Hu, Wenjie, Cui, Yu, Gao, Jingchen, Yao, Xujin, Ren, Jinyang, Lin, Tao, Sun, Jiangdong, Gao, Yunyi, Li, Xiaohua, Wang, Hui, Li, Huanting, Che, Fengyuan, Wan, Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Brain Ischemia - metabolism Cell Biology Cerebral Infarction Cholesterol Electrical stimulation of the brain ESB Fermentation Glucose - metabolism Ischemia Lon protein Neurobiology Neurology Neuroprotection Neuroprotective Agents - pharmacology Neurosciences Oxygen - metabolism Propionic acid Protease La - metabolism Protein transport PTEN Phosphohydrolase - metabolism PTEN protein Rats Reperfusion Reperfusion Injury - metabolism Transcranial Direct Current Stimulation
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