Parkinsonism-Hyperpyrexia Syndrome: A Case Series and Literature Review
Parkinsonism-hyperpyrexia syndrome (PHS) is a rare, potentially fatal neurological emergency, that is seen in Parkinson’s Disease (PD) patients and mimics neuroleptic malignant syndrome. The most common trigger for PHS is sudden withdrawal of anti-parkinsonian medications, specifically levodopa. How...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-09, Vol.14 (9) |
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| container_title | Curēus (Palo Alto, CA) |
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| creator | Azar, Jehad Jaber, Yasmin Ayyad, Mohammed Abu alia, Walaa Owda, Fahed Sharabati, Haneen Zeid, Hiba Khreshi, Suleiman AlBandak, Maram Sayyed Ahmad, Dana |
| description | Parkinsonism-hyperpyrexia syndrome (PHS) is a rare, potentially fatal neurological emergency, that is seen in Parkinson’s Disease (PD) patients and mimics neuroleptic malignant syndrome. The most common trigger for PHS is sudden withdrawal of anti-parkinsonian medications, specifically levodopa. However, it can also be due to Deep Brain Stimulation (DBS) device malfunction. In this work, we describe three cases of PHS; the first of which is related to DBS battery depletion, and the remaining two to dopaminergic withdrawal. Additionally, we will include the results of a literature review on PHS, its etiologies, presentation, and management. |
| doi_str_mv | 10.7759/cureus.29646 |
| format | Article |
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The most common trigger for PHS is sudden withdrawal of anti-parkinsonian medications, specifically levodopa. However, it can also be due to Deep Brain Stimulation (DBS) device malfunction. In this work, we describe three cases of PHS; the first of which is related to DBS battery depletion, and the remaining two to dopaminergic withdrawal. 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| subjects | Internal Medicine Medical Education Neurology |
| title | Parkinsonism-Hyperpyrexia Syndrome: A Case Series and Literature Review |
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