Vascular Protective Effects of Malus toringoides (Rehd.) Hughes Extracts and their Mechanism in Diabetic Rats and HUVECs
Malus toringoides (Rehd.) Hughes (Rosaceae) is used as a traditional folk medicine in the Tibet autonomous region of China to treat hypertension, hyperglycemia, and hyperlipidemia. However, few modern pharmacological data on the use of this plant against diabetic syndrome are available. In this stud...
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| creator | Wang, Xiangyu Wang, Tong Gao, Liying Dikye, Tsering Dong, Linsha Yuan, Ruiying Meng, Ning Yang, Jing Woo, Eun-Rhan Lee, Dong-Sung Wang, Yuefei Li, Bin Huang, Shan |
| description | Malus toringoides (Rehd.) Hughes (Rosaceae) is used as a traditional folk medicine in the Tibet autonomous region of China to treat hypertension, hyperglycemia, and hyperlipidemia. However, few modern pharmacological data on the use of this plant against diabetic syndrome are available. In this study, we examined the vascular protection provided by a 70% ethanol extract of M. toringoides (EMT) in human umbilical vein endothelial cells (HUVECs) grown in high-glucose medium and in a high-fat diet/streptozotocin-induced rat diabetes model. EMT significantly suppressed the expression of cell adhesion molecules in both HUVECs and diabetic rats. EMT also inhibited activation of the CX3CL1/CX3CR1 axis and the nuclear factor kappa B (NF-κB) signaling pathway in vivo and in vitro. The results provide a significant information on the vasoprotective properties of M. toringoides that may contribute to the development and application of related herbal medicines. |
| doi_str_mv | 10.1155/2022/4348435 |
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Hughes Extracts and their Mechanism in Diabetic Rats and HUVECs</title><source>Wiley Online Library Open Access</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Wang, Xiangyu ; Wang, Tong ; Gao, Liying ; Dikye, Tsering ; Dong, Linsha ; Yuan, Ruiying ; Meng, Ning ; Yang, Jing ; Woo, Eun-Rhan ; Lee, Dong-Sung ; Wang, Yuefei ; Li, Bin ; Huang, Shan</creator><contributor>Kang, Wen Yi</contributor><creatorcontrib>Wang, Xiangyu ; Wang, Tong ; Gao, Liying ; Dikye, Tsering ; Dong, Linsha ; Yuan, Ruiying ; Meng, Ning ; Yang, Jing ; Woo, Eun-Rhan ; Lee, Dong-Sung ; Wang, Yuefei ; Li, Bin ; Huang, Shan ; Kang, Wen Yi</creatorcontrib><description>Malus toringoides (Rehd.) Hughes (Rosaceae) is used as a traditional folk medicine in the Tibet autonomous region of China to treat hypertension, hyperglycemia, and hyperlipidemia. However, few modern pharmacological data on the use of this plant against diabetic syndrome are available. In this study, we examined the vascular protection provided by a 70% ethanol extract of M. toringoides (EMT) in human umbilical vein endothelial cells (HUVECs) grown in high-glucose medium and in a high-fat diet/streptozotocin-induced rat diabetes model. EMT significantly suppressed the expression of cell adhesion molecules in both HUVECs and diabetic rats. EMT also inhibited activation of the CX3CL1/CX3CR1 axis and the nuclear factor kappa B (NF-κB) signaling pathway in vivo and in vitro. The results provide a significant information on the vasoprotective properties of M. toringoides that may contribute to the development and application of related herbal medicines.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/4348435</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Abdomen ; Animals ; Antibodies ; Atherosclerosis ; Cell adhesion molecules ; Chemokines ; Cholesterol ; CX3CR1 protein ; Diabetes ; Diabetes mellitus ; Drug dosages ; Endothelial cells ; Ethanol ; Fatty acids ; Flavonoids ; Glucose ; Herbal medicine ; High density lipoprotein ; High fat diet ; Hyperglycemia ; Hyperlipidemia ; Kinases ; NF-κB protein ; Oxidative stress ; Proteins ; Reagents ; Rodents ; Signal transduction ; Streptozocin ; Tumor necrosis factor-TNF ; Umbilical vein</subject><ispartof>Evidence-based complementary and alternative medicine, 2022-10, Vol.2022, p.1-14</ispartof><rights>Copyright © 2022 Xiangyu Wang et al.</rights><rights>Copyright © 2022 Xiangyu Wang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Xiangyu Wang et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-5c4aea7767b155d6e8e7b307068e6888c0997b5c530e3863f86e97176f34896a3</citedby><cites>FETCH-LOGICAL-c425t-5c4aea7767b155d6e8e7b307068e6888c0997b5c530e3863f86e97176f34896a3</cites><orcidid>0000-0001-5345-8398 ; 0000-0001-6079-1076 ; 0000-0003-0956-6046</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605824/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605824/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><contributor>Kang, Wen Yi</contributor><creatorcontrib>Wang, Xiangyu</creatorcontrib><creatorcontrib>Wang, Tong</creatorcontrib><creatorcontrib>Gao, Liying</creatorcontrib><creatorcontrib>Dikye, Tsering</creatorcontrib><creatorcontrib>Dong, Linsha</creatorcontrib><creatorcontrib>Yuan, Ruiying</creatorcontrib><creatorcontrib>Meng, Ning</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Woo, Eun-Rhan</creatorcontrib><creatorcontrib>Lee, Dong-Sung</creatorcontrib><creatorcontrib>Wang, Yuefei</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><creatorcontrib>Huang, Shan</creatorcontrib><title>Vascular Protective Effects of Malus toringoides (Rehd.) Hughes Extracts and their Mechanism in Diabetic Rats and HUVECs</title><title>Evidence-based complementary and alternative medicine</title><description>Malus toringoides (Rehd.) Hughes (Rosaceae) is used as a traditional folk medicine in the Tibet autonomous region of China to treat hypertension, hyperglycemia, and hyperlipidemia. However, few modern pharmacological data on the use of this plant against diabetic syndrome are available. In this study, we examined the vascular protection provided by a 70% ethanol extract of M. toringoides (EMT) in human umbilical vein endothelial cells (HUVECs) grown in high-glucose medium and in a high-fat diet/streptozotocin-induced rat diabetes model. EMT significantly suppressed the expression of cell adhesion molecules in both HUVECs and diabetic rats. EMT also inhibited activation of the CX3CL1/CX3CR1 axis and the nuclear factor kappa B (NF-κB) signaling pathway in vivo and in vitro. The results provide a significant information on the vasoprotective properties of M. toringoides that may contribute to the development and application of related herbal medicines.</description><subject>Abdomen</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Atherosclerosis</subject><subject>Cell adhesion molecules</subject><subject>Chemokines</subject><subject>Cholesterol</subject><subject>CX3CR1 protein</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Drug dosages</subject><subject>Endothelial cells</subject><subject>Ethanol</subject><subject>Fatty acids</subject><subject>Flavonoids</subject><subject>Glucose</subject><subject>Herbal medicine</subject><subject>High density lipoprotein</subject><subject>High fat diet</subject><subject>Hyperglycemia</subject><subject>Hyperlipidemia</subject><subject>Kinases</subject><subject>NF-κB protein</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Reagents</subject><subject>Rodents</subject><subject>Signal transduction</subject><subject>Streptozocin</subject><subject>Tumor necrosis factor-TNF</subject><subject>Umbilical vein</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90c9LHDEUB_ChtFBre-sfEOjFYlfzO5lLoaxrV1AsUqW3kMm82YnMJjaZsfrfN-suQnvwlBfy4fFevlX1keAjQoQ4ppjSY8645ky8qvaI4mTGqdavn2v16231LudbjGmtlNqrHm5sdtNgE_qR4ghu9PeAFl1Xqoxihy7sMGU0xuTDKvoWMjq4gr49-oyW06ov18XDmOwG29CisQef0AW43gaf18gHdOJtA6N36Mru0PL6ZjHP76s3nR0yfNid-9X16eLnfDk7v_x-Nv92PnOcinEmHLdglZKqKRu2EjSohmGFpQaptXa4rlUjnGAYmJas0xJqRZTsyjfU0rL96uu2793UrKF1EMq8g7lLfm3To4nWm39fgu_NKt6bWmKhKS8NDnYNUvw9QR7N2mcHw2ADxCkbqhiWXEpGCv30H72NUwplvSdFhGaUFfVlq1yKOSfonoch2GxyNJsczS7Hwg-3vPehtX_8y_ovHR-cWg</recordid><startdate>20221019</startdate><enddate>20221019</enddate><creator>Wang, Xiangyu</creator><creator>Wang, Tong</creator><creator>Gao, Liying</creator><creator>Dikye, Tsering</creator><creator>Dong, Linsha</creator><creator>Yuan, Ruiying</creator><creator>Meng, Ning</creator><creator>Yang, Jing</creator><creator>Woo, Eun-Rhan</creator><creator>Lee, Dong-Sung</creator><creator>Wang, Yuefei</creator><creator>Li, Bin</creator><creator>Huang, Shan</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5345-8398</orcidid><orcidid>https://orcid.org/0000-0001-6079-1076</orcidid><orcidid>https://orcid.org/0000-0003-0956-6046</orcidid></search><sort><creationdate>20221019</creationdate><title>Vascular Protective Effects of Malus toringoides (Rehd.) Hughes Extracts and their Mechanism in Diabetic Rats and HUVECs</title><author>Wang, Xiangyu ; Wang, Tong ; Gao, Liying ; Dikye, Tsering ; Dong, Linsha ; Yuan, Ruiying ; Meng, Ning ; Yang, Jing ; Woo, Eun-Rhan ; Lee, Dong-Sung ; Wang, Yuefei ; Li, Bin ; Huang, Shan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-5c4aea7767b155d6e8e7b307068e6888c0997b5c530e3863f86e97176f34896a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abdomen</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Atherosclerosis</topic><topic>Cell adhesion molecules</topic><topic>Chemokines</topic><topic>Cholesterol</topic><topic>CX3CR1 protein</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Drug dosages</topic><topic>Endothelial cells</topic><topic>Ethanol</topic><topic>Fatty acids</topic><topic>Flavonoids</topic><topic>Glucose</topic><topic>Herbal medicine</topic><topic>High density lipoprotein</topic><topic>High fat diet</topic><topic>Hyperglycemia</topic><topic>Hyperlipidemia</topic><topic>Kinases</topic><topic>NF-κB protein</topic><topic>Oxidative stress</topic><topic>Proteins</topic><topic>Reagents</topic><topic>Rodents</topic><topic>Signal transduction</topic><topic>Streptozocin</topic><topic>Tumor necrosis factor-TNF</topic><topic>Umbilical vein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiangyu</creatorcontrib><creatorcontrib>Wang, Tong</creatorcontrib><creatorcontrib>Gao, Liying</creatorcontrib><creatorcontrib>Dikye, Tsering</creatorcontrib><creatorcontrib>Dong, Linsha</creatorcontrib><creatorcontrib>Yuan, Ruiying</creatorcontrib><creatorcontrib>Meng, Ning</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Woo, Eun-Rhan</creatorcontrib><creatorcontrib>Lee, Dong-Sung</creatorcontrib><creatorcontrib>Wang, Yuefei</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><creatorcontrib>Huang, Shan</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiangyu</au><au>Wang, Tong</au><au>Gao, Liying</au><au>Dikye, Tsering</au><au>Dong, Linsha</au><au>Yuan, Ruiying</au><au>Meng, Ning</au><au>Yang, Jing</au><au>Woo, Eun-Rhan</au><au>Lee, Dong-Sung</au><au>Wang, Yuefei</au><au>Li, Bin</au><au>Huang, Shan</au><au>Kang, Wen Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular Protective Effects of Malus toringoides (Rehd.) 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EMT also inhibited activation of the CX3CL1/CX3CR1 axis and the nuclear factor kappa B (NF-κB) signaling pathway in vivo and in vitro. The results provide a significant information on the vasoprotective properties of M. toringoides that may contribute to the development and application of related herbal medicines.</abstract><cop>New York</cop><pub>Hindawi</pub><doi>10.1155/2022/4348435</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5345-8398</orcidid><orcidid>https://orcid.org/0000-0001-6079-1076</orcidid><orcidid>https://orcid.org/0000-0003-0956-6046</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Animals Antibodies Atherosclerosis Cell adhesion molecules Chemokines Cholesterol CX3CR1 protein Diabetes Diabetes mellitus Drug dosages Endothelial cells Ethanol Fatty acids Flavonoids Glucose Herbal medicine High density lipoprotein High fat diet Hyperglycemia Hyperlipidemia Kinases NF-κB protein Oxidative stress Proteins Reagents Rodents Signal transduction Streptozocin Tumor necrosis factor-TNF Umbilical vein |
| title | Vascular Protective Effects of Malus toringoides (Rehd.) Hughes Extracts and their Mechanism in Diabetic Rats and HUVECs |
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