Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study
Large-scale Asian studies on this topic are lacking. We evaluated the CRC risk associated with family history in the Korean population. We analyzed the data of participants aged ≥40 years who underwent national cancer screening between 2013 and 2014. During a mean follow-up of 4.7 ± 0.8 years, 0.43%...
Gespeichert in:
| Veröffentlicht in: | Journal of personalized medicine 2022-09, Vol.12 (10), p.1566 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 1566 |
| container_title | Journal of personalized medicine |
| container_volume | 12 |
| creator | Jung, Yoon Suk Song, Huiyeon Tran, Mai Thi Xuan Park, Boyoung Moon, Chang Mo |
| description | Large-scale Asian studies on this topic are lacking. We evaluated the CRC risk associated with family history in the Korean population. We analyzed the data of participants aged ≥40 years who underwent national cancer screening between 2013 and 2014. During a mean follow-up of 4.7 ± 0.8 years, 0.43% of the 292,467 participants with family history and 0.28% of the 1,169,868 participants without family history developed CRC. Participants with a family history in any FDR, parents only, and siblings only had a higher risk of CRC than those without family history; adjusted hazard ratios (HRs) were 1.53, 1.46, and 1.61, respectively. Participants with a family history comprising both parents and siblings had an even higher risk of CRC than those without a family history (HR, 2.34). The HRs for CRC in the 40−49, 50−59, 60−69, 70−79, and ≥80 age groups with family history were 1.72, 1.74, 1.50, 1.30, and 0.78, respectively (p < 0.001). A family history of CRC in any FDR and both parents and siblings was associated with an approximately 1.5- and 2.3-fold increased risk of CRC. The effect of family history was relatively greater in the younger than the older age group. |
| doi_str_mv | 10.3390/jpm12101566 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9605451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2729517007</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-abdc6e5451b23336615eddb31e3ae817ebf2b34cd578cb51a8b7103ef638ec013</originalsourceid><addsrcrecordid>eNptkctr3DAQh0VoaUKaU-9B0EuhONXDku0eCtslLwhJ6OMs9Bg32trWRpIT9pY_vd682JToIg36-GaGH0IfKDngvCFfFsueMkqokHIL7TBSiaIsmXyz8d5GeyktyHRqwZgk79A2l6wpKyJ30N0spWC9zj4M2EC-BRjwDB_p3ncrfOJTDnGFQ4vnoQsRbNYdnuvBQsR6cDhfAf7h099Xia-T6PzefOsd4MuwHLv7sviuEzj8M49u9R69bXWXYO_x3kW_jw5_zU-Ks4vj0_nsrLAlaXKhjbMSRCmoYZxzKakA5wynwDXUtALTMsNL60RVWyOork1FCYdW8hosoXwXfXvwLkfTg7Mw5Kg7tYy-13Glgvbq5c_gr9SfcKMaSdZtJ8GnR0EM1yOkrHqfLHSdHiCMSbGKNYJWhFQT-vE_dBHGOEzrram6rFndrIWfHygbQ0oR2udhKFHrcNVGuBO9vzn_M_sUJf8Hoo2g1A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2728482891</pqid></control><display><type>article</type><title>Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Jung, Yoon Suk ; Song, Huiyeon ; Tran, Mai Thi Xuan ; Park, Boyoung ; Moon, Chang Mo</creator><creatorcontrib>Jung, Yoon Suk ; Song, Huiyeon ; Tran, Mai Thi Xuan ; Park, Boyoung ; Moon, Chang Mo</creatorcontrib><description>Large-scale Asian studies on this topic are lacking. We evaluated the CRC risk associated with family history in the Korean population. We analyzed the data of participants aged ≥40 years who underwent national cancer screening between 2013 and 2014. During a mean follow-up of 4.7 ± 0.8 years, 0.43% of the 292,467 participants with family history and 0.28% of the 1,169,868 participants without family history developed CRC. Participants with a family history in any FDR, parents only, and siblings only had a higher risk of CRC than those without family history; adjusted hazard ratios (HRs) were 1.53, 1.46, and 1.61, respectively. Participants with a family history comprising both parents and siblings had an even higher risk of CRC than those without a family history (HR, 2.34). The HRs for CRC in the 40−49, 50−59, 60−69, 70−79, and ≥80 age groups with family history were 1.72, 1.74, 1.50, 1.30, and 0.78, respectively (p < 0.001). A family history of CRC in any FDR and both parents and siblings was associated with an approximately 1.5- and 2.3-fold increased risk of CRC. The effect of family history was relatively greater in the younger than the older age group.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm12101566</identifier><identifier>PMID: 36294706</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Alcohol ; Asian studies ; Aspirin ; Body mass index ; Cancer ; Cancer screening ; Cohort analysis ; Colonoscopy ; Colorectal cancer ; Colorectal carcinoma ; Family medical history ; Illnesses ; Medical screening ; National health insurance ; Population ; Population studies ; Population-based studies ; Precision medicine ; Questionnaires ; Siblings</subject><ispartof>Journal of personalized medicine, 2022-09, Vol.12 (10), p.1566</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-abdc6e5451b23336615eddb31e3ae817ebf2b34cd578cb51a8b7103ef638ec013</citedby><cites>FETCH-LOGICAL-c409t-abdc6e5451b23336615eddb31e3ae817ebf2b34cd578cb51a8b7103ef638ec013</cites><orcidid>0000-0002-4294-0880 ; 0000-0003-2550-913X ; 0000-0003-1902-3184 ; 0000-0002-1963-7170</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605451/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9605451/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36294706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Yoon Suk</creatorcontrib><creatorcontrib>Song, Huiyeon</creatorcontrib><creatorcontrib>Tran, Mai Thi Xuan</creatorcontrib><creatorcontrib>Park, Boyoung</creatorcontrib><creatorcontrib>Moon, Chang Mo</creatorcontrib><title>Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study</title><title>Journal of personalized medicine</title><addtitle>J Pers Med</addtitle><description>Large-scale Asian studies on this topic are lacking. We evaluated the CRC risk associated with family history in the Korean population. We analyzed the data of participants aged ≥40 years who underwent national cancer screening between 2013 and 2014. During a mean follow-up of 4.7 ± 0.8 years, 0.43% of the 292,467 participants with family history and 0.28% of the 1,169,868 participants without family history developed CRC. Participants with a family history in any FDR, parents only, and siblings only had a higher risk of CRC than those without family history; adjusted hazard ratios (HRs) were 1.53, 1.46, and 1.61, respectively. Participants with a family history comprising both parents and siblings had an even higher risk of CRC than those without a family history (HR, 2.34). The HRs for CRC in the 40−49, 50−59, 60−69, 70−79, and ≥80 age groups with family history were 1.72, 1.74, 1.50, 1.30, and 0.78, respectively (p < 0.001). A family history of CRC in any FDR and both parents and siblings was associated with an approximately 1.5- and 2.3-fold increased risk of CRC. The effect of family history was relatively greater in the younger than the older age group.</description><subject>Age</subject><subject>Alcohol</subject><subject>Asian studies</subject><subject>Aspirin</subject><subject>Body mass index</subject><subject>Cancer</subject><subject>Cancer screening</subject><subject>Cohort analysis</subject><subject>Colonoscopy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Family medical history</subject><subject>Illnesses</subject><subject>Medical screening</subject><subject>National health insurance</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Precision medicine</subject><subject>Questionnaires</subject><subject>Siblings</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkctr3DAQh0VoaUKaU-9B0EuhONXDku0eCtslLwhJ6OMs9Bg32trWRpIT9pY_vd682JToIg36-GaGH0IfKDngvCFfFsueMkqokHIL7TBSiaIsmXyz8d5GeyktyHRqwZgk79A2l6wpKyJ30N0spWC9zj4M2EC-BRjwDB_p3ncrfOJTDnGFQ4vnoQsRbNYdnuvBQsR6cDhfAf7h099Xia-T6PzefOsd4MuwHLv7sviuEzj8M49u9R69bXWXYO_x3kW_jw5_zU-Ks4vj0_nsrLAlaXKhjbMSRCmoYZxzKakA5wynwDXUtALTMsNL60RVWyOork1FCYdW8hosoXwXfXvwLkfTg7Mw5Kg7tYy-13Glgvbq5c_gr9SfcKMaSdZtJ8GnR0EM1yOkrHqfLHSdHiCMSbGKNYJWhFQT-vE_dBHGOEzrram6rFndrIWfHygbQ0oR2udhKFHrcNVGuBO9vzn_M_sUJf8Hoo2g1A</recordid><startdate>20220923</startdate><enddate>20220923</enddate><creator>Jung, Yoon Suk</creator><creator>Song, Huiyeon</creator><creator>Tran, Mai Thi Xuan</creator><creator>Park, Boyoung</creator><creator>Moon, Chang Mo</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4294-0880</orcidid><orcidid>https://orcid.org/0000-0003-2550-913X</orcidid><orcidid>https://orcid.org/0000-0003-1902-3184</orcidid><orcidid>https://orcid.org/0000-0002-1963-7170</orcidid></search><sort><creationdate>20220923</creationdate><title>Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study</title><author>Jung, Yoon Suk ; Song, Huiyeon ; Tran, Mai Thi Xuan ; Park, Boyoung ; Moon, Chang Mo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-abdc6e5451b23336615eddb31e3ae817ebf2b34cd578cb51a8b7103ef638ec013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Alcohol</topic><topic>Asian studies</topic><topic>Aspirin</topic><topic>Body mass index</topic><topic>Cancer</topic><topic>Cancer screening</topic><topic>Cohort analysis</topic><topic>Colonoscopy</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Family medical history</topic><topic>Illnesses</topic><topic>Medical screening</topic><topic>National health insurance</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Precision medicine</topic><topic>Questionnaires</topic><topic>Siblings</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Yoon Suk</creatorcontrib><creatorcontrib>Song, Huiyeon</creatorcontrib><creatorcontrib>Tran, Mai Thi Xuan</creatorcontrib><creatorcontrib>Park, Boyoung</creatorcontrib><creatorcontrib>Moon, Chang Mo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of personalized medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Yoon Suk</au><au>Song, Huiyeon</au><au>Tran, Mai Thi Xuan</au><au>Park, Boyoung</au><au>Moon, Chang Mo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study</atitle><jtitle>Journal of personalized medicine</jtitle><addtitle>J Pers Med</addtitle><date>2022-09-23</date><risdate>2022</risdate><volume>12</volume><issue>10</issue><spage>1566</spage><pages>1566-</pages><issn>2075-4426</issn><eissn>2075-4426</eissn><abstract>Large-scale Asian studies on this topic are lacking. We evaluated the CRC risk associated with family history in the Korean population. We analyzed the data of participants aged ≥40 years who underwent national cancer screening between 2013 and 2014. During a mean follow-up of 4.7 ± 0.8 years, 0.43% of the 292,467 participants with family history and 0.28% of the 1,169,868 participants without family history developed CRC. Participants with a family history in any FDR, parents only, and siblings only had a higher risk of CRC than those without family history; adjusted hazard ratios (HRs) were 1.53, 1.46, and 1.61, respectively. Participants with a family history comprising both parents and siblings had an even higher risk of CRC than those without a family history (HR, 2.34). The HRs for CRC in the 40−49, 50−59, 60−69, 70−79, and ≥80 age groups with family history were 1.72, 1.74, 1.50, 1.30, and 0.78, respectively (p < 0.001). A family history of CRC in any FDR and both parents and siblings was associated with an approximately 1.5- and 2.3-fold increased risk of CRC. The effect of family history was relatively greater in the younger than the older age group.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36294706</pmid><doi>10.3390/jpm12101566</doi><orcidid>https://orcid.org/0000-0002-4294-0880</orcidid><orcidid>https://orcid.org/0000-0003-2550-913X</orcidid><orcidid>https://orcid.org/0000-0003-1902-3184</orcidid><orcidid>https://orcid.org/0000-0002-1963-7170</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2075-4426 |
| ispartof | Journal of personalized medicine, 2022-09, Vol.12 (10), p.1566 |
| issn | 2075-4426 2075-4426 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9605451 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Age Alcohol Asian studies Aspirin Body mass index Cancer Cancer screening Cohort analysis Colonoscopy Colorectal cancer Colorectal carcinoma Family medical history Illnesses Medical screening National health insurance Population Population studies Population-based studies Precision medicine Questionnaires Siblings |
| title | Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T14%3A31%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20A%20Family%20History%20of%20Colorectal%20Cancer%20and%20the%20Risk%20of%20Colorectal%20Cancer:%20A%20Nationwide%20Population-Based%20Study&rft.jtitle=Journal%20of%20personalized%20medicine&rft.au=Jung,%20Yoon%20Suk&rft.date=2022-09-23&rft.volume=12&rft.issue=10&rft.spage=1566&rft.pages=1566-&rft.issn=2075-4426&rft.eissn=2075-4426&rft_id=info:doi/10.3390/jpm12101566&rft_dat=%3Cproquest_pubme%3E2729517007%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2728482891&rft_id=info:pmid/36294706&rfr_iscdi=true |