H4K5 Butyrylation Coexist with Acetylation during Human Spermiogenesis and Are Retained in the Mature Sperm Chromatin

Male germ cells experience a drastic chromatin remodeling through the nucleo-histone to nucleo-protamine (NH-NP) transition necessary for proper sperm functionality. Post-translational modifications (PTMs) of H4 Lys5, such as acetylation (H4K5ac), play a crucial role in epigenetic control of nucleos...

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Veröffentlicht in:	International journal of molecular sciences 2022-10, Vol.23 (20), p.12398
Hauptverfasser:	de la Iglesia, Alberto, Jauregi, Paula, Jodar, Meritxell, Barrachina, Ferran, Ded, Lukas, Mallofré, Carme, Rodríguez-Carunchio, Leonardo, Corral, Juan Manuel, Ballescà, Josep Lluís, Komrskova, Katerina, Castillo, Judit, Oliva, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Chromatin remodeling Dismantling Elongation Epigenetics Genomes Germ cells Histones Nucleosomes Patients Post-translation Protamine Retention Sperm Spermatids Spermatogenesis Spermiogenesis Testicular cancer Zygotes
Online-Zugang:	Volltext
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