Selective and Reversible 1,3-Dipolar Cycloaddition of 2-(2-Oxoindoline-3-ylidene)acetates with Nitrones in the Synthesis of Functionalized Spiroisoxazolidines

The 1,3-dipolar cycloaddition of 2-(2-oxoindoline-3-ylidene)acetates with functionalized aldo- and ketonitrones proceeds with good selectivity to provide new highly functionalized 5-spiroisoxazolidines. A characteristic feature of these reactions is reversibility that allows for the control of the d...

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Veröffentlicht in:	International journal of molecular sciences 2022-10, Vol.23 (20), p.12639
Hauptverfasser:	Karcev, Dmitriy D., Efremova, Mariia M., Molchanov, Alexander P., Rostovskii, Nikolai V., Kryukova, Mariya A., Bunev, Alexander S., Khochenkov, Dmitry A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Acetic acid Adducts Alcohol Antitumor activity Breast cancer Cycloaddition Pharmaceutical sciences Selectivity Spiro compounds Stereoselectivity
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