Anti-PTK7 Monoclonal Antibodies Exhibit Anti-Tumor Activity at the Cellular Level and in Mouse Xenograft Models of Esophageal Squamous Cell Carcinoma

PTK7 is a catalytically defective receptor protein tyrosine kinase upregulated in various cancers, including esophageal squamous cell carcinoma (ESCC). In previous studies, we observed a positive correlation between PTK7 expression levels and tumorigenicity in various ESCC cell lines and xenograft m...

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Veröffentlicht in:	International journal of molecular sciences 2022-10, Vol.23 (20), p.12195
Hauptverfasser:	Kim, Jae Hoon, Shin, Won-Sik, Lee, Se-Ra, Kim, Sanggil, Choi, So-Young, Lee, Seung-Taek
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animal models Breast cancer Cancer therapies Cell culture Cell growth Cell proliferation Chemotherapy Cytoskeleton Epidermal growth factor Esophageal cancer Extracellular signal-regulated kinase Gelatinase B Invasiveness Kinases Medical prognosis Monoclonal antibodies Phosphorylation Polymerization Protein-tyrosine kinase Proteins Squamous cell carcinoma Tumor necrosis factor-TNF Tumorigenesis Tumorigenicity Tumors Tyrosine Wound healing Xenografts Xenotransplantation
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