Jatrorrhizine Improves Endothelial Function in Diabetes and Obesity through Suppression of Endoplasmic Reticulum Stress

Jatrorrhizine (JAT) is one of the major bioactive protoberberine alkaloids found in rhizoma coptidis, which has hypoglycemic and hypolipidemic potential. This study aimed to evaluate the vasoprotective effects of JAT in diabetes and obesity and the underlying mechanism involved. Mouse aortas, caroti...

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Veröffentlicht in:	International journal of molecular sciences 2022-10, Vol.23 (20), p.12064
Hauptverfasser:	Zhou, Yan, Wang, Yuehan, Vong, Chi Teng, Zhu, Yanyan, Xu, Baojun, Ruan, Cheng-Chao, Wang, Yitao, Cheang, Wai San
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism AKT protein Alanine Alanine transaminase Alanine Transaminase - metabolism Animals Aspartate aminotransferase Aspartate Aminotransferases - metabolism Bioavailability Blood pressure Cholesterol Diabetes Diabetes mellitus Diabetes Mellitus - metabolism Drugs, Chinese Herbal - pharmacology Endoplasmic reticulum Endoplasmic Reticulum Stress Endothelial cells Endothelium Endothelium, Vascular - metabolism Fatty liver Glucose Glucose - metabolism High fat diet Human Umbilical Vein Endothelial Cells - metabolism Humans Hyperglycemia Hypoglycemic Agents - pharmacology Kinases Lipids Lipids - pharmacology Lipoproteins Liver Metabolism Mice Mice, Inbred C57BL Nitric oxide Obesity Obesity - metabolism Oral administration Oxidative Stress Phosphorylation Plasma levels Proteins Proto-Oncogene Proteins c-akt - metabolism Risk analysis Risk factors Smooth muscle Transaminases Tunicamycin Tunicamycin - pharmacology Umbilical cord
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