Interactions between Environmental Factors and Glutathione S-Transferase (GST) Genes with Respect to Detectable Blood Aluminum Concentrations in Jamaican Children
Aluminum (Al) is a metallic toxicant at high concentrations following natural or unnatural exposures. Dietary intake is considered as the main source of aluminum exposure in children. We used data from 366 typically developing (TD) children (ages 2−8 years) who participated as controls in an age- an...
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| Veröffentlicht in: | Genes 2022-10, Vol.13 (10), p.1907 |
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| creator | Rahbar, Mohammad H Samms-Vaughan, Maureen Zhao, Yuansong Saroukhani, Sepideh Bressler, Jan Hessabi, Manouchehr Grove, Megan L Shakespeare-Pellington, Sydonnie Loveland, Katherine A |
| description | Aluminum (Al) is a metallic toxicant at high concentrations following natural or unnatural exposures. Dietary intake is considered as the main source of aluminum exposure in children. We used data from 366 typically developing (TD) children (ages 2−8 years) who participated as controls in an age- and sex-matched case−control study in Jamaica. We investigated additive and interactive associations among environmental factors and children’s genotypes for glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1), in relation to having a detectable blood aluminum concentration (BAlC) of >5.0 μg/L, using multivariable logistic regression models. Findings from interactive models revealed that the odds of having a detectable BAlC was significantly higher among children who ate string beans (p ≤ 0.01), whereas about 40% lower odds of having a detectable BAlC was observed in children with higher parental education level, (p = 0.02). A significant interaction between consumption of saltwater fish and GSTP1 in relation to having a detectable BAlC using either co-dominant or dominant genetic models (overall interaction p = 0.02 for both models) indicated that consumption of saltwater fish was associated with higher odds of having a detectable BAlC only among children with the GSTP1 Ile105Val Ile/Ile genotype using either co-dominant or dominant models [OR (95% CI) = 2.73 (1.07, 6.96), p = 0.04; and OR (95% CI) = 2.74 (1.08, 6.99), p = 0.03]. Since this is the first study from Jamaica that reports such findings, replication in other populations is warranted. |
| doi_str_mv | 10.3390/genes13101907 |
| format | Article |
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Dietary intake is considered as the main source of aluminum exposure in children. We used data from 366 typically developing (TD) children (ages 2−8 years) who participated as controls in an age- and sex-matched case−control study in Jamaica. We investigated additive and interactive associations among environmental factors and children’s genotypes for glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1), in relation to having a detectable blood aluminum concentration (BAlC) of >5.0 μg/L, using multivariable logistic regression models. Findings from interactive models revealed that the odds of having a detectable BAlC was significantly higher among children who ate string beans (p ≤ 0.01), whereas about 40% lower odds of having a detectable BAlC was observed in children with higher parental education level, (p = 0.02). A significant interaction between consumption of saltwater fish and GSTP1 in relation to having a detectable BAlC using either co-dominant or dominant genetic models (overall interaction p = 0.02 for both models) indicated that consumption of saltwater fish was associated with higher odds of having a detectable BAlC only among children with the GSTP1 Ile105Val Ile/Ile genotype using either co-dominant or dominant models [OR (95% CI) = 2.73 (1.07, 6.96), p = 0.04; and OR (95% CI) = 2.74 (1.08, 6.99), p = 0.03]. Since this is the first study from Jamaica that reports such findings, replication in other populations is warranted.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes13101907</identifier><identifier>PMID: 36292793</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Additives ; Aluminum ; Aluminum - toxicity ; Analysis and chemistry ; Autism ; Blood ; Blood levels ; Case-Control Studies ; Children ; Dietary intake ; Environmental aspects ; Environmental factors ; Enzymes ; Food additives ; Genes ; Genetic aspects ; Genotypes ; Glutathione S-Transferase pi - genetics ; Glutathione transferase ; Glutathione Transferase - genetics ; GSTM1 protein ; GSTT1 protein ; Health aspects ; Jamaica ; Laboratory animals ; Nutrition research ; Physiological aspects ; Polymorphism ; Polymorphism, Genetic ; Population ; Regression analysis ; Sociodemographics ; Toxicants</subject><ispartof>Genes, 2022-10, Vol.13 (10), p.1907</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c438t-4e9f8ac12daf22c0a66f2716eed020e2debfcbbe0a6d65c70f878051a6ea1b5a3</cites><orcidid>0000-0002-5090-0985 ; 0000-0002-5910-9954</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601654/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601654/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36292793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahbar, Mohammad H</creatorcontrib><creatorcontrib>Samms-Vaughan, Maureen</creatorcontrib><creatorcontrib>Zhao, Yuansong</creatorcontrib><creatorcontrib>Saroukhani, Sepideh</creatorcontrib><creatorcontrib>Bressler, Jan</creatorcontrib><creatorcontrib>Hessabi, Manouchehr</creatorcontrib><creatorcontrib>Grove, Megan L</creatorcontrib><creatorcontrib>Shakespeare-Pellington, Sydonnie</creatorcontrib><creatorcontrib>Loveland, Katherine A</creatorcontrib><title>Interactions between Environmental Factors and Glutathione S-Transferase (GST) Genes with Respect to Detectable Blood Aluminum Concentrations in Jamaican Children</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>Aluminum (Al) is a metallic toxicant at high concentrations following natural or unnatural exposures. Dietary intake is considered as the main source of aluminum exposure in children. We used data from 366 typically developing (TD) children (ages 2−8 years) who participated as controls in an age- and sex-matched case−control study in Jamaica. We investigated additive and interactive associations among environmental factors and children’s genotypes for glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1), in relation to having a detectable blood aluminum concentration (BAlC) of >5.0 μg/L, using multivariable logistic regression models. Findings from interactive models revealed that the odds of having a detectable BAlC was significantly higher among children who ate string beans (p ≤ 0.01), whereas about 40% lower odds of having a detectable BAlC was observed in children with higher parental education level, (p = 0.02). A significant interaction between consumption of saltwater fish and GSTP1 in relation to having a detectable BAlC using either co-dominant or dominant genetic models (overall interaction p = 0.02 for both models) indicated that consumption of saltwater fish was associated with higher odds of having a detectable BAlC only among children with the GSTP1 Ile105Val Ile/Ile genotype using either co-dominant or dominant models [OR (95% CI) = 2.73 (1.07, 6.96), p = 0.04; and OR (95% CI) = 2.74 (1.08, 6.99), p = 0.03]. Since this is the first study from Jamaica that reports such findings, replication in other populations is warranted.</description><subject>Additives</subject><subject>Aluminum</subject><subject>Aluminum - toxicity</subject><subject>Analysis and chemistry</subject><subject>Autism</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Case-Control Studies</subject><subject>Children</subject><subject>Dietary intake</subject><subject>Environmental aspects</subject><subject>Environmental factors</subject><subject>Enzymes</subject><subject>Food additives</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genotypes</subject><subject>Glutathione S-Transferase pi - genetics</subject><subject>Glutathione transferase</subject><subject>Glutathione Transferase - genetics</subject><subject>GSTM1 protein</subject><subject>GSTT1 protein</subject><subject>Health aspects</subject><subject>Jamaica</subject><subject>Laboratory animals</subject><subject>Nutrition research</subject><subject>Physiological aspects</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Population</subject><subject>Regression analysis</subject><subject>Sociodemographics</subject><subject>Toxicants</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptUktv1DAQjhCIVqVHrsgSFzik-JHEyQVpu7RLUSUkupytiTPedZXYi-204u_wS3G1pdpK2AeP_D38jTVF8ZbRMyE6-mmDDiMTjLKOyhfFMadSlFXF65cH9VFxGuMtzauinNL6dXEkGt5x2Ynj4s-VSxhAJ-tdJD2me0RHLtydDd5N6BKM5DLDPkQCbiCrcU6QtpmN5KZcB3DRZH1E8mF1s_5IVg-JyL1NW_ID4w51IsmTL5hyBf2I5Hz0fiCLcZ6smyey9E7nVwLsA1hHvsEEVoMjy60dh4DuTfHKwBjx9PE8KX5eXqyXX8vr76ur5eK61JVoU1lhZ1rQjA9gONcUmsZwyRrEIbeNfMDe6L7HDAxNrSU1rWxpzaBBYH0N4qT4vPfdzf2Ewz7WqHbBThB-Kw9WPUec3aqNv1NdQ1lTV9ng_aNB8L9mjEnd-jm4nFlxydtKth0_YG1gRGWd8dlMTzZqtZBVLbkQlGXW2X9YeQ84WZ1_39h8_0xQ7gU6-BgDmqfgjKqHYVHPhiXz3x12-8T-NxriL4BBvhA</recordid><startdate>20221020</startdate><enddate>20221020</enddate><creator>Rahbar, Mohammad H</creator><creator>Samms-Vaughan, Maureen</creator><creator>Zhao, Yuansong</creator><creator>Saroukhani, Sepideh</creator><creator>Bressler, Jan</creator><creator>Hessabi, Manouchehr</creator><creator>Grove, Megan L</creator><creator>Shakespeare-Pellington, Sydonnie</creator><creator>Loveland, Katherine A</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5090-0985</orcidid><orcidid>https://orcid.org/0000-0002-5910-9954</orcidid></search><sort><creationdate>20221020</creationdate><title>Interactions between Environmental Factors and Glutathione S-Transferase (GST) Genes with Respect to Detectable Blood Aluminum Concentrations in Jamaican Children</title><author>Rahbar, Mohammad H ; Samms-Vaughan, Maureen ; Zhao, Yuansong ; Saroukhani, Sepideh ; Bressler, Jan ; Hessabi, Manouchehr ; Grove, Megan L ; Shakespeare-Pellington, Sydonnie ; Loveland, Katherine A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-4e9f8ac12daf22c0a66f2716eed020e2debfcbbe0a6d65c70f878051a6ea1b5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Additives</topic><topic>Aluminum</topic><topic>Aluminum - toxicity</topic><topic>Analysis and chemistry</topic><topic>Autism</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Case-Control Studies</topic><topic>Children</topic><topic>Dietary intake</topic><topic>Environmental aspects</topic><topic>Environmental factors</topic><topic>Enzymes</topic><topic>Food additives</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genotypes</topic><topic>Glutathione S-Transferase pi - genetics</topic><topic>Glutathione transferase</topic><topic>Glutathione Transferase - genetics</topic><topic>GSTM1 protein</topic><topic>GSTT1 protein</topic><topic>Health aspects</topic><topic>Jamaica</topic><topic>Laboratory animals</topic><topic>Nutrition research</topic><topic>Physiological aspects</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Population</topic><topic>Regression analysis</topic><topic>Sociodemographics</topic><topic>Toxicants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahbar, Mohammad H</creatorcontrib><creatorcontrib>Samms-Vaughan, Maureen</creatorcontrib><creatorcontrib>Zhao, Yuansong</creatorcontrib><creatorcontrib>Saroukhani, Sepideh</creatorcontrib><creatorcontrib>Bressler, Jan</creatorcontrib><creatorcontrib>Hessabi, Manouchehr</creatorcontrib><creatorcontrib>Grove, Megan L</creatorcontrib><creatorcontrib>Shakespeare-Pellington, Sydonnie</creatorcontrib><creatorcontrib>Loveland, Katherine A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahbar, Mohammad H</au><au>Samms-Vaughan, Maureen</au><au>Zhao, Yuansong</au><au>Saroukhani, Sepideh</au><au>Bressler, Jan</au><au>Hessabi, Manouchehr</au><au>Grove, Megan L</au><au>Shakespeare-Pellington, Sydonnie</au><au>Loveland, Katherine A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interactions between Environmental Factors and Glutathione S-Transferase (GST) Genes with Respect to Detectable Blood Aluminum Concentrations in Jamaican Children</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2022-10-20</date><risdate>2022</risdate><volume>13</volume><issue>10</issue><spage>1907</spage><pages>1907-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>Aluminum (Al) is a metallic toxicant at high concentrations following natural or unnatural exposures. Dietary intake is considered as the main source of aluminum exposure in children. We used data from 366 typically developing (TD) children (ages 2−8 years) who participated as controls in an age- and sex-matched case−control study in Jamaica. We investigated additive and interactive associations among environmental factors and children’s genotypes for glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1), in relation to having a detectable blood aluminum concentration (BAlC) of >5.0 μg/L, using multivariable logistic regression models. Findings from interactive models revealed that the odds of having a detectable BAlC was significantly higher among children who ate string beans (p ≤ 0.01), whereas about 40% lower odds of having a detectable BAlC was observed in children with higher parental education level, (p = 0.02). A significant interaction between consumption of saltwater fish and GSTP1 in relation to having a detectable BAlC using either co-dominant or dominant genetic models (overall interaction p = 0.02 for both models) indicated that consumption of saltwater fish was associated with higher odds of having a detectable BAlC only among children with the GSTP1 Ile105Val Ile/Ile genotype using either co-dominant or dominant models [OR (95% CI) = 2.73 (1.07, 6.96), p = 0.04; and OR (95% CI) = 2.74 (1.08, 6.99), p = 0.03]. Since this is the first study from Jamaica that reports such findings, replication in other populations is warranted.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36292793</pmid><doi>10.3390/genes13101907</doi><orcidid>https://orcid.org/0000-0002-5090-0985</orcidid><orcidid>https://orcid.org/0000-0002-5910-9954</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Additives Aluminum Aluminum - toxicity Analysis and chemistry Autism Blood Blood levels Case-Control Studies Children Dietary intake Environmental aspects Environmental factors Enzymes Food additives Genes Genetic aspects Genotypes Glutathione S-Transferase pi - genetics Glutathione transferase Glutathione Transferase - genetics GSTM1 protein GSTT1 protein Health aspects Jamaica Laboratory animals Nutrition research Physiological aspects Polymorphism Polymorphism, Genetic Population Regression analysis Sociodemographics Toxicants |
| title | Interactions between Environmental Factors and Glutathione S-Transferase (GST) Genes with Respect to Detectable Blood Aluminum Concentrations in Jamaican Children |
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