Dietary Interventions in Cancer Treatment and Response: A Comprehensive Review
Chemotherapy and radiotherapy are first-line treatments in the management of advanced solid tumors. Whereas these treatments are directed at eliminating cancer cells, they cause significant adverse effects that can be detrimental to a patient's quality of life and even life-threatening. Diet is...
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Veröffentlicht in: | Cancers 2022-10, Vol.14 (20), p.5149 |
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description | Chemotherapy and radiotherapy are first-line treatments in the management of advanced solid tumors. Whereas these treatments are directed at eliminating cancer cells, they cause significant adverse effects that can be detrimental to a patient's quality of life and even life-threatening. Diet is a modifiable risk factor that has been shown to affect cancer risk, recurrence, and treatment toxicity, but little information is known how diet interacts with cancer treatment modalities. Although dietary interventions, such as intermittent fasting and ketogenic diets, have shown promise in pre-clinical studies by reducing the toxicity and increasing the efficacy of chemotherapeutics, there remains a limited number of clinical studies in this space. This review surveys the impact of dietary interventions (caloric restriction, intermittent and short-term fasting, and ketogenic diet) on cancer treatment outcomes in both pre-clinical and clinical studies. Early studies support a complementary role for these dietary interventions in improving patient quality of life across multiple cancer types by reducing toxicity and perhaps a benefit in treatment efficacy. Larger, phase III, randomized clinical trials are ultimately necessary to evaluate the efficacy of these dietary interventions in improving oncologic or quality of life outcomes for patients that are undergoing chemotherapy or radiotherapy. |
doi_str_mv | 10.3390/cancers14205149 |
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Whereas these treatments are directed at eliminating cancer cells, they cause significant adverse effects that can be detrimental to a patient's quality of life and even life-threatening. Diet is a modifiable risk factor that has been shown to affect cancer risk, recurrence, and treatment toxicity, but little information is known how diet interacts with cancer treatment modalities. Although dietary interventions, such as intermittent fasting and ketogenic diets, have shown promise in pre-clinical studies by reducing the toxicity and increasing the efficacy of chemotherapeutics, there remains a limited number of clinical studies in this space. This review surveys the impact of dietary interventions (caloric restriction, intermittent and short-term fasting, and ketogenic diet) on cancer treatment outcomes in both pre-clinical and clinical studies. Early studies support a complementary role for these dietary interventions in improving patient quality of life across multiple cancer types by reducing toxicity and perhaps a benefit in treatment efficacy. Larger, phase III, randomized clinical trials are ultimately necessary to evaluate the efficacy of these dietary interventions in improving oncologic or quality of life outcomes for patients that are undergoing chemotherapy or radiotherapy.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14205149</identifier><identifier>PMID: 36291933</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>20th century ; Antioxidants ; Calories ; Cancer ; Cancer therapies ; Carbohydrates ; Care and treatment ; Cell division ; Chemotherapy ; Clinical trials ; Diet ; Diet therapy ; Dietary restrictions ; Disease prevention ; DNA damage ; Fasting ; Fatty acids ; High fat diet ; Ketogenesis ; Leukemia ; Low carbohydrate diet ; Metabolism ; Metastases ; Methods ; Morbidity ; Nutrition research ; Oxidative stress ; Patients ; Phosphorylation ; Quality of life ; Radiation therapy ; Review ; Risk factors ; Solid tumors ; Toxicity ; Tumors</subject><ispartof>Cancers, 2022-10, Vol.14 (20), p.5149</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-fe072b6f81173cf6d1d7965577fa9014fc81851eb91adc477e2cfa08f3c678883</citedby><cites>FETCH-LOGICAL-c488t-fe072b6f81173cf6d1d7965577fa9014fc81851eb91adc477e2cfa08f3c678883</cites><orcidid>0000-0002-9349-7962</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600754/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600754/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36291933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mercier, Benjamin D</creatorcontrib><creatorcontrib>Tizpa, Eemon</creatorcontrib><creatorcontrib>Philip, Errol J</creatorcontrib><creatorcontrib>Feng, Qianhua</creatorcontrib><creatorcontrib>Huang, Ziyi</creatorcontrib><creatorcontrib>Thomas, Reeny M</creatorcontrib><creatorcontrib>Pal, Sumanta K</creatorcontrib><creatorcontrib>Dorff, Tanya B</creatorcontrib><creatorcontrib>Li, Yun R</creatorcontrib><title>Dietary Interventions in Cancer Treatment and Response: A Comprehensive Review</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Chemotherapy and radiotherapy are first-line treatments in the management of advanced solid tumors. Whereas these treatments are directed at eliminating cancer cells, they cause significant adverse effects that can be detrimental to a patient's quality of life and even life-threatening. Diet is a modifiable risk factor that has been shown to affect cancer risk, recurrence, and treatment toxicity, but little information is known how diet interacts with cancer treatment modalities. Although dietary interventions, such as intermittent fasting and ketogenic diets, have shown promise in pre-clinical studies by reducing the toxicity and increasing the efficacy of chemotherapeutics, there remains a limited number of clinical studies in this space. This review surveys the impact of dietary interventions (caloric restriction, intermittent and short-term fasting, and ketogenic diet) on cancer treatment outcomes in both pre-clinical and clinical studies. Early studies support a complementary role for these dietary interventions in improving patient quality of life across multiple cancer types by reducing toxicity and perhaps a benefit in treatment efficacy. Larger, phase III, randomized clinical trials are ultimately necessary to evaluate the efficacy of these dietary interventions in improving oncologic or quality of life outcomes for patients that are undergoing chemotherapy or radiotherapy.</description><subject>20th century</subject><subject>Antioxidants</subject><subject>Calories</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carbohydrates</subject><subject>Care and treatment</subject><subject>Cell division</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Diet</subject><subject>Diet therapy</subject><subject>Dietary restrictions</subject><subject>Disease prevention</subject><subject>DNA damage</subject><subject>Fasting</subject><subject>Fatty acids</subject><subject>High fat diet</subject><subject>Ketogenesis</subject><subject>Leukemia</subject><subject>Low carbohydrate diet</subject><subject>Metabolism</subject><subject>Metastases</subject><subject>Methods</subject><subject>Morbidity</subject><subject>Nutrition research</subject><subject>Oxidative stress</subject><subject>Patients</subject><subject>Phosphorylation</subject><subject>Quality of life</subject><subject>Radiation therapy</subject><subject>Review</subject><subject>Risk factors</subject><subject>Solid tumors</subject><subject>Toxicity</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptUUlLAzEUDqKoqGdvMuC5mkwyWTwIpW4FURA9hzTzopFOUpNpxX9v3OqCySGP9y18Lw-hXYIPKFX40JpgIWXCatwQplbQZo1FPeBcsdUf9QbayfkRl0MpEVysow3Ka0UUpZvo6sRDb9JLNQ49pAWE3seQKx-q0bt7dZvA9F3pVya01Q3kWcHhqBpWo9jNEjxAyH4BBVl4eN5Ga85MM-x8vlvo7uz0dnQxuLw-H4-GlwPLpOwHDkq4CXeSEEGt4y1pheJNI4QzChPmrCSyITBRxLSWCQG1dQZLRy0XUkq6hY4_fGfzSQetLfmSmepZ8l0ZRkfj9W8k-Ad9HxdacYxFw4rB_qdBik9zyL1-jPMUSmZdi1oyynHTfLPuzRS0Dy4WM9v5bPVQsKYwy5cW1sE_rHJb6LyNAZwv_V-Cww-BTTHnBG4ZnGD9tlr9Z7VFsfdz3iX_a5H0FTztn44</recordid><startdate>20221020</startdate><enddate>20221020</enddate><creator>Mercier, Benjamin D</creator><creator>Tizpa, Eemon</creator><creator>Philip, Errol J</creator><creator>Feng, Qianhua</creator><creator>Huang, Ziyi</creator><creator>Thomas, Reeny M</creator><creator>Pal, Sumanta K</creator><creator>Dorff, Tanya B</creator><creator>Li, Yun R</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9349-7962</orcidid></search><sort><creationdate>20221020</creationdate><title>Dietary Interventions in Cancer Treatment and Response: A Comprehensive Review</title><author>Mercier, Benjamin D ; 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Whereas these treatments are directed at eliminating cancer cells, they cause significant adverse effects that can be detrimental to a patient's quality of life and even life-threatening. Diet is a modifiable risk factor that has been shown to affect cancer risk, recurrence, and treatment toxicity, but little information is known how diet interacts with cancer treatment modalities. Although dietary interventions, such as intermittent fasting and ketogenic diets, have shown promise in pre-clinical studies by reducing the toxicity and increasing the efficacy of chemotherapeutics, there remains a limited number of clinical studies in this space. This review surveys the impact of dietary interventions (caloric restriction, intermittent and short-term fasting, and ketogenic diet) on cancer treatment outcomes in both pre-clinical and clinical studies. Early studies support a complementary role for these dietary interventions in improving patient quality of life across multiple cancer types by reducing toxicity and perhaps a benefit in treatment efficacy. Larger, phase III, randomized clinical trials are ultimately necessary to evaluate the efficacy of these dietary interventions in improving oncologic or quality of life outcomes for patients that are undergoing chemotherapy or radiotherapy.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36291933</pmid><doi>10.3390/cancers14205149</doi><orcidid>https://orcid.org/0000-0002-9349-7962</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | 20th century Antioxidants Calories Cancer Cancer therapies Carbohydrates Care and treatment Cell division Chemotherapy Clinical trials Diet Diet therapy Dietary restrictions Disease prevention DNA damage Fasting Fatty acids High fat diet Ketogenesis Leukemia Low carbohydrate diet Metabolism Metastases Methods Morbidity Nutrition research Oxidative stress Patients Phosphorylation Quality of life Radiation therapy Review Risk factors Solid tumors Toxicity Tumors |
title | Dietary Interventions in Cancer Treatment and Response: A Comprehensive Review |
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