Dihydroceramide desaturase 1 (DES1) promotes anchorage‐independent survival downstream of HER2‐driven glucose uptake and metabolism

Oncogenic reprogramming of cellular metabolism is a hallmark of many cancers, but our mechanistic understanding of how such dysregulation is linked to tumor behavior remains poor. In this study, we have identified dihydroceramide desaturase (DES1)—which catalyzes the last step in de novo sphingolipi...

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Veröffentlicht in:	The FASEB journal 2022-10, Vol.36 (10), p.e22558-n/a
Hauptverfasser:	Linzer, Ryan W., Guida, Danielle L., Aminov, Jonathan, Snider, Justin M., Khalife, Gabrielle, Buyukbayraktar, A. Burak, Alhaddad, Charbel, Resnick, Andrew E., Wang, Pule, Pan, Chun‐Hao, Allopenna, Janet J., Clarke, Christopher J.
Format:	Artikel
Sprache:	eng
Schlagworte:	breast cancer cell survival metastasis oncogene sphingolipid
Online-Zugang:	Volltext
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