Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF- κB signaling pathways

We aim to evaluate the effects of auranofin, a known antioxidant, on hepatic steatosis, inflammation, and fibrosis, contributing to non-alcoholic steatohepatitis (NASH) development in vivo and in vitro. Transcriptome analysis of LX-2 cells was that expression patterns of genes changed by auranofin,...

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Veröffentlicht in:	Clinical and molecular hepatology 2022-10, Vol.28 (4), p.827-840
Hauptverfasser:	Lee, Seung Min, Koh, Dong Hee, Jun, Dae Won, Roh, Yoon Jin, Kang, Hyeon Tae, Oh, Ju Hee, Kim, Hyun Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis Auranofin - metabolism Auranofin - pharmacology Auranofin - therapeutic use Collagen - metabolism Collagen - pharmacology Endothelin-1 - metabolism Endothelin-1 - pharmacology Fibronectins - metabolism Fibronectins - pharmacology Humans Inflammation Inflammatory diseases Liver - pathology Liver cancer Liver Cirrhosis - pathology Liver diseases Mice Mice, Inbred C57BL NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism NF-E2-Related Factor 2 - pharmacology NF-kappa B - metabolism NF-kappa B - pharmacology NF-KappaB Inhibitor alpha - metabolism Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Original Oxidative stress Palmitic Acid - metabolism Palmitic Acid - toxicity Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction Thrombospondin 1 - metabolism Thrombospondin 1 - pharmacology Transcription factors Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology Transforming Growth Factors - metabolism Transforming Growth Factors - pharmacology
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