Prognostic significance of pathogenic variants in BRCA1, BRCA2, ATM and PALB2 genes in men undergoing hormonal therapy for advanced prostate cancer

Background The prognostic significance of germline variants in homologous recombination repair genes in advanced prostate cancer (PCa), especially with regard to hormonal therapy, remains controversial. Methods Germline DNA from 549 Japanese men with metastatic and/or castration-resistant PCa was se...

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Veröffentlicht in:	British journal of cancer 2022-11, Vol.127 (9), p.1680-1690
Hauptverfasser:	Kimura, Hiroko, Mizuno, Kei, Shiota, Masaki, Narita, Shintaro, Terada, Naoki, Fujimoto, Naohiro, Ogura, Keiji, Hatano, Shotaro, Iwasaki, Yusuke, Hakozaki, Nozomi, Ishitoya, Satoshi, Sumiyoshi, Takayuki, Goto, Takayuki, Kobayashi, Takashi, Nakagawa, Hidewaki, Kamoto, Toshiyuki, Eto, Masatoshi, Habuchi, Tomonori, Ogawa, Osamu, Momozawa, Yukihide, Akamatsu, Shusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4028/67/68 692/53/2422 692/699/2768/1753/466 Ataxia Telangiectasia Mutated Proteins - genetics Biomedical and Life Sciences Biomedicine Biopsy BRCA1 protein BRCA1 Protein - genetics BRCA2 protein BRCA2 Protein - genetics Cancer Research Castration Drug Resistance Epidemiology Fanconi Anemia Complementation Group N Protein - genetics Genes, BRCA2 Genetic Predisposition to Disease Germ-Line Mutation Homologous recombination Homologous recombination repair Humans Male Medical prognosis Metastases Metastasis Molecular Medicine Mutation Oncology p53 Protein Patients Prognosis Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology
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